1944
DOI: 10.1152/jn.1944.7.6.391
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Pial Circulation and Spreading Depression of Activity in the Cerebral Cortex

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Cited by 291 publications
(134 citation statements)
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“…This decreased CBF has been found in models of subarachnoid hemorrhage (Dreier et al, 1998) and focal ischemia (Shin et al, 2006;Strong et al, 2007), and new evidence exists that they may cause secondary ischemic damage in human brains after subarachnoid hemorrhage Iadecola, 2009). In the normally perfused brain, in contrast, CBF increases in response to CSD as already shown by Leao (1944b) in the second of his two memorable articles.…”
Section: Introductionmentioning
confidence: 70%
“…This decreased CBF has been found in models of subarachnoid hemorrhage (Dreier et al, 1998) and focal ischemia (Shin et al, 2006;Strong et al, 2007), and new evidence exists that they may cause secondary ischemic damage in human brains after subarachnoid hemorrhage Iadecola, 2009). In the normally perfused brain, in contrast, CBF increases in response to CSD as already shown by Leao (1944b) in the second of his two memorable articles.…”
Section: Introductionmentioning
confidence: 70%
“…This, together with regular detection of transient (a) negativity of the cortical surface DC potential and (b) increase in extracellular potassium ion concentration, also features of CSD, led to the designation of such events as PIDs (Hossmann, 1996) when observed in the ischaemic penumbra. A first-and critical-difference between CSD and PID events is that whereas CSD is accompanied by marked, but transient hyperaemia (Leão, 1944a;Lauritzen et al, 1982), perfusion (as measured by laser Doppler probe) may fall transiently in association with a PID (Back et al, 1994). Secondly, CSD is not associated with histologic evidence of cytotoxicity (Nedergaard and Hansen, 1988), whereas there is a clear, direct relationship of infarct size with number of PIDs during a period of ischaemia (Mies et al, 1993), and infarct size is the dependent variable (Takano et al, 1996;Busch et al, 1996;Back et al, 1996).…”
Section: Rationale For Use Of the Laser Speckle Methods In Stroke Modementioning
confidence: 99%
“…This knowledge allowed to better understanding the pathophysiology of several acute brain disorders, offering references box. Leão's seminal papers on spreading depression 5,6,7,8 .…”
Section: Resultsmentioning
confidence: 99%
“…Here, the studies advanced in relation to Leão' s findings, by identifying the main electrophysiological occurrence, and its underpinnings, where SD continues as an important electrophysiological feature. Since Leão' s discovery, SD has been implicated by him, and soon by other authors, in migraine 6,8 . Although it has been known that ischemia could also trigger SD, as shown by Leão 7,8 , it was not until the 80' s that recurrent SD-like depolarization waves were demonstrated in focal brain ischemia, which occurred as peri-infarct depolarizations (injury depolarizations, spreading depolarization), at the edge between the ischemic core and the penumbra rim.…”
Section: The Discovery Of the "Spreading Depression"mentioning
confidence: 95%
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