.pi.-Dicarbollyl derivatives of the transition metals. Metallocene analogs

Hawthorne, M. Frederick; Young, Donald Clifford; Andrews, Timothy D.; Howe, D. V.; Pilling, Richard L.; Pitts, A. Denise; Reintjes, Marten; Warren, Leslie F.; Wegner, Patrick A.

doi:10.1021/ja01006a008

Cited by 660 publications

(282 citation statements)

References 4 publications

Supporting

Mentioning

268

Contrasting

Unclassified

Order By: Relevance

“…Cobalt bis(dicarbollide) [3,3'-Co(1,2-C2B9H11)2] − was prepared for the first time fifty years ago [113,114] and it still remains the subject of the increasing interest [115] due to good perspectives of its application in various fields starting from medicine [116][117][118] and finishing with nuclear waste treatment [119], and weakly coordinating anions is one of them.…”

Section: Silver and Copper Complexes With Cobalt Bis(dicarbollide) Anmentioning

confidence: 99%

Silver and Copper Complexes with closo-Polyhedral Borane, Carborane and Metallacarborane Anions: Synthesis and X-ray Structure

et al. 2016

View full text Add to dashboard Cite

show abstract

Section: Silver and Copper Complexes With Cobalt Bis(dicarbollide) Anmentioning

confidence: 99%

Silver and Copper Complexes with closo-Polyhedral Borane, Carborane and Metallacarborane Anions: Synthesis and X-ray Structure

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Thus, very efficient ir-bonding ligands would be expected to form complexes of great stability with these radionuclides. Hawthorne and coworkers (11,12) first described commo-bisdicarbollide transition metal complexes in which the metal ion is held between two ir-bonding…”

mentioning

confidence: 99%

A transition metal complex (Venus flytrap cluster) for radioimmunodetection and radioimmunotherapy.

Paxton

Beatty

Hawthorne

et al. 1991

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

A transition metal complex (Venus flytrap cluster) for radioimmunodetection and radioimmunotherapy ( ABSTRACTA novel transition metal complex, Venus flytrap cluster (VFC), is described for the preparation of radiolabeled antibodies. VFC contained "Co, which was held tightly between the faces of two covalently bridged carborane ligands by cluster bonding of the metal with appropriate ligand orbitals. Anti-carcinoembryonic antigen monoclonal antibody T84.66 was conjugated to 57Co-VFC with full retention of immunological activity. Biodistribution studies in nude mice bearing carcinoembryonic antigen-producing tumors showed excellent tumor localization of 57Co-VFC-T84.66. The accumulation of radionuclide in normal liver was low and independent of dose, which may reflect the stability of the radionuclide complex. These results presage the use of VFC systems for binding transition metals that are clinically useful for radioimmunodiagnosis and radioimmunotherapy.The use of monoclonal and engineered antibodies for the selective delivery of diagnostic and therapeutic radiometals to tumors requires suitable bifunctional reagents that efficiently form covalent bonds with antibody and stable radionuclide chelate complexes. With few exceptions, monoclonal antibody (mAb)-chelator conjugates have been prepared with bifunctional reagents that are members of the aminocarboxylate chelator family, with derivatives of diethylenetriaminepentaacetic acid (DTPA) and ethylenediaminetetraacetic acid (EDTA) being most popular (1-5). These conjugates form stable radiopharmaceuticals with 1"'In that have been used for radioimmunodiagnosis of human tumors (6-8), although there is some concern about their uptake by normal tissues and possible metal release in vivo. Conjugates of this type, however, form less stable radiopharmaceuticals with 90Y and 67Cu (9, 10), which can be used for radioimmunotherapy. There is therefore considerable interest in the development of new bifunctional reagents that will form more stable chelate complexes with these and other clinically relevant radionuclides.Radionuclides such as 67Cu, 991Tc, 105Rh, and '86Re are transition metals. Thus, very efficient ir-bonding ligands would be expected to form complexes of great stability with these radionuclides. Hawthorne and coworkers (11, 12) first described commo-bisdicarbollide transition metal complexes in which the metal ion is held between two ir-bonding[C2B9H11]2-dicarbollide ligands. With d6 metal ions these complexes conform to both the 18-electron and cluster electron-counting rules and display extraordinary stability due to the cluster bonding of the transition metal with ligand orbitals of appropriate symmetry. Metal ions having other than six d electrons, such as d3Cr3+ and d8Cu3+, also form stable bis-dicarbollide clusters, although in the case of electron-rich (d7, d8, etc.) species, the dicarbollide ligands undergo a "slip" distortion (12). The ability to produce these complexes in high yield in aqueous media, their expected stability to physiological co...

show abstract

“…15 Among the polyhedral boranes, the family of isomeric icosahedral dicarbaboranes (closo-C 2 B 10 H 12 ) 15 and their metallo-derivatives 16 have received much attention because of their varied chemistry, 17 redox properties, 18 thermal stability, and their potential for applications in the areas of medicine 19 and materials chemistry. 15 Recently we reported a series of MOFs that are derived from closo-1,12-C 2 B 10 H 12 (para-carborane).…”

Section: ■ Introductionmentioning

confidence: 99%

Carborane-Based Metal-Organic Framework with High Methane and Hydrogen Storage Capacities

Kennedy¹,

Krungleviciute²,

Clingerman³

et al. 2013

View full text Add to dashboard Cite

A Cu−carborane-based metal−organic framework (MOF), NU-135, which contains a quasi-spherical para-carborane moiety, has been synthesized and characterized. NU-135 exhibits a pore volume of 1.02 cm 3 /g and a gravimetric BET surface area of ca. 2600 m 2 /g, and thus represents the first highly porous carborane-based MOF. As a consequence of the unique geometry of the carborane unit, NU-135 has a very high volumetric BET surface area of ca. 1900 m 2 /cm 3 . CH 4 , CO 2 , and H 2 adsorption isotherms were measured over a broad range of pressures and temperatures and are in good agreement with computational predictions. The methane storage capacity of NU-135 at 35 bar and 298 K is ca. 187 v STP /v. At 298 K, the pressure required to achieve a methane storage density comparable to that of a compressed natural gas (CNG) tank pressurized to 212 bar, which is a typical storage pressure, is only 65 bar. The methane working capacity (5−65 bar) is 170 v STP /v. The volumetric hydrogen storage capacity at 55 bar and 77 K is 49 g/L. These properties are comparable to those of current record holders in the area of methane and hydrogen storage. This initial example lays the groundwork for carborane-based materials with high surface areas.

show abstract

.pi.-Dicarbollyl derivatives of the transition metals. Metallocene analogs

Cited by 660 publications

References 4 publications

Silver and Copper Complexes with closo-Polyhedral Borane, Carborane and Metallacarborane Anions: Synthesis and X-ray Structure

Silver and Copper Complexes with closo-Polyhedral Borane, Carborane and Metallacarborane Anions: Synthesis and X-ray Structure

A transition metal complex (Venus flytrap cluster) for radioimmunodetection and radioimmunotherapy.

Carborane-Based Metal-Organic Framework with High Methane and Hydrogen Storage Capacities

Contact Info

Product

Resources

About