Phytotoxins produced by <i>Didymella glomerata</i> and <i>Truncatella angustata</i>, associated with grapevine trunk diseases (GTDs) in Iran

Cimmino, Alessio; Bahmani, Zeinab; Masi, Marco; Abdollahzadeh, Jafar; Amini, Jahanshir; Tuzi, Angela; Evidente, Antonio

doi:10.1080/14786419.2021.1979544

Cited by 11 publications

(9 citation statements)

References 17 publications

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“…For metabolite production, T. angustata was inoculated and grown in a stationary culture (final volume 5 L) of the Potato Dextrose Broth (PDB) as previously reported . The lyophilized culture filtrates (5 L) of T.…”

Section: Methodsmentioning

confidence: 76%

“…The lyophilized culture filtrates (5 L) of T. angustata were dissolved in 1/10 of the initial volume (pH 6) and extracted with EtOAc as recently reported . The organic extracts were combined, dried (Na 2 SO 4 ), and evaporated under reduced pressure, giving a corresponding residue of 330 mg.…”

Section: Methodsmentioning

confidence: 99%

“…Truncatella angustata was recently reported as one of the causal agents of GTDs in Iran and was shown to produce (+)-6-hydroxyramulosin, a well-known phytotoxin . Surprisingly, T.…”

Section: Introductionmentioning

confidence: 99%

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Phenazine-1-Carboxylic Acid (PCA), Produced for the First Time as an Antifungal Metabolite by Truncatella angustata, a Causal Agent of Grapevine Trunk Diseases (GTDs) in Iran

Cimmino

Bahmani

Castaldi

et al. 2021

J. Agric. Food Chem.

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The phytopathogenic fungus Truncatella angustata, associated with grapevine trunk diseases (GTDs) in Iran, produces the well-known secondary metabolite isocoumumarin (+)-6-hyroxyramulosin and surprisingly also phenazine-1-carboxylic acid (PCA). PCA, identified by spectroscopic (essentially 1 H NMR and ESI MS) spectra, is a bacterial metabolite well known for its antifungal activity and was found for the first time in T. angustata culture filtrates. The antifungal activity of PCA was assayed against four different fungi responsible for GTDs, Phaeoacremonium minimum, Phaeoacremonium italicum, Fomitiporia mediterranea, involved in grapevine esca disease, and Neofusicoccum parvum, responsible for Botryosphaeria dieback. The activity was compared with that of the known commercial fungicide, pentachloronitrobenzene, and the close phenazine. PCA and phenazine exhibited strong antifungal activity against all phytopathogenic fungi, inhibiting the fungal growth by about 90−100% and 80−100%, respectively. These results suggested that T. angustata could use PCA to compete with other phytopathogenic fungi that attack grapevine and thus PCA could be proposed as a biofungicide against the fungi responsible for grapevine esca and Botryosphaeria dieback diseases.

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Section: Methodsmentioning

confidence: 76%

Section: Methodsmentioning

confidence: 99%

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Phenazine-1-Carboxylic Acid (PCA), Produced for the First Time as an Antifungal Metabolite by Truncatella angustata, a Causal Agent of Grapevine Trunk Diseases (GTDs) in Iran

Cimmino

Bahmani

Castaldi

et al. 2021

J. Agric. Food Chem.

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“…were recently shown to be associated with decline ( K. variispora ) and vascular necrosis ( K. longispora ) of V. vinifera [ 30 , 102 ]. Further taxa that were identified at genus level only in our study are Seimatosporium , Neofabrea , and Truncatella ; related species known as pathogens on grapevine are S. vitis , N. kienholzii , T. angustata [ 29 , 103 , 104 , 105 , 106 , 107 , 108 ]. Apart from the above pathogens, a fungal genus with strong potential for biological control against GTD fungi, i.e., Clonostachys , was found [ 109 , 110 ].…”

Section: Discussionmentioning

confidence: 82%

Minimal versus Intensive: How the Pruning Intensity Affects Occurrence of Grapevine Leaf Stripe Disease, Wood Integrity, and the Mycobiome in Grapevine Trunks

Kraus

Rauch

Kalvelage

et al. 2022

JoF

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Previous works on grapevine-trunk diseases indicate that minimal or non-pruning of the grapevine under certain circumstances can significantly reduce the risk of symptom expression. Nevertheless, knowledge of the mechanisms behind these observations are limited. Therefore, it was the aim of this study to investigate in more detail the effect of pruning intensity on the grapevine trunk by means of trunk integrity and the fungal community in the wood tissue. Two German vineyards partially trained in vertical-shoot position and semi-minimally pruned hedges were chosen for this survey due to the accessibility of multi-annual esca-monitoring data. The results revealed that only in one of the two vineyards was the incidence of external esca symptoms significantly reduced over a period of five years (2017–2021) by minimal pruning, which was up to 73.7% compared to intensive pruning. In both vineyards, the trunks of intensively pruned vines not only had more pruning wounds on the trunk (by 86.0% and 72.9%, respectively) than minimally pruned vines, but also exhibited a larger (by 19.3% and 14.7%, respectively) circumference of the trunk head. In addition, the percentage of white rot and necrosis in the trunks of esca-positive and esca-negative vines was analyzed and compared between the two pruning intensities; hereby, significant differences were only found for esca-negative ‘Dornfelder’ vines, in which the proportion of necrosis was higher for intensively pruned vines (23.0%) than for minimally pruned vines (11.5%). The fungal communities of the differently pruned vine trunks were mainly dominated by four genera, which are also associated with GTDs: Diplodia, Eutypa, Fomitiporia and Phaeomoniella. All in all, the fungal diversity and community composition did not differ between minimally and intensively pruned, esca-positive vines.

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“…In addition to plants, this fungus was also isolated from marine sponges ( 13 ), humans ( 4 ), and as a pathogen from insects ( 14 ). T. angustata cultures showed several secondary metabolites with potential for application in biotechnology or medicine, e.g., α-pyrone-based analogs ( 15 ), phenazine-1-carboxylic acid with antifungal activity ( 6 ), ramulosin derivates with a broad range of biological activities ( 14 , 16 ), and truncateols, isoprenylated cyclohexanols with antiviral activity ( 15 , 17 ). In culture supernatants, isolate S358 showed activities of several oxidoreductases, including those of unspecific peroxygenase and laccase.…”

Section: Announcementmentioning

confidence: 99%

Draft Genome Sequence of Truncatella angustata (Anamorph) S358

Kellner

Friedrich

Schmidtke

et al. 2022

Microbiol Resour Announc

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Phytotoxins produced by Didymella glomerata and Truncatella angustata, associated with grapevine trunk diseases (GTDs) in Iran

Cited by 11 publications

References 17 publications

Phenazine-1-Carboxylic Acid (PCA), Produced for the First Time as an Antifungal Metabolite by Truncatella angustata, a Causal Agent of Grapevine Trunk Diseases (GTDs) in Iran

Phenazine-1-Carboxylic Acid (PCA), Produced for the First Time as an Antifungal Metabolite by Truncatella angustata, a Causal Agent of Grapevine Trunk Diseases (GTDs) in Iran

Minimal versus Intensive: How the Pruning Intensity Affects Occurrence of Grapevine Leaf Stripe Disease, Wood Integrity, and the Mycobiome in Grapevine Trunks

Draft Genome Sequence of Truncatella angustata (Anamorph) S358

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