Phytotoxicity of veterinary antibiotics to seed germination and root elongation of crops

Pan, Min; Chu, L.M.

doi:10.1016/j.ecoenv.2015.12.027

Cited by 190 publications

(75 citation statements)

References 39 publications

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“…In the case of plants, there is evidence to suggest that seed germination, root elongation and overall plant health can be sensitive to sub-inhibitory concentrations of antibiotics and metals in the soil (Pan and Chu, 2016). Exposure to sub-lethal concentrations of pollutants such as antibiotics, biocides, and metals can induce pollution-induced parasitization, which in turn has been shown to increase susceptibility to the toxic effects of the pollutant (Khan and Thulin, 1991).…”

Section: Relevance Of Amr To Environmental Regulators?mentioning

confidence: 99%

Review of Antimicrobial Resistance in the Environment and Its Relevance to Environmental Regulators

et al. 2016

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The environment is increasingly being recognized for the role it might play in the global spread of clinically relevant antibiotic resistance. Environmental regulators monitor and control many of the pathways responsible for the release of resistance-driving chemicals into the environment (e.g., antimicrobials, metals, and biocides). Hence, environmental regulators should be contributing significantly to the development of global and national antimicrobial resistance (AMR) action plans. It is argued that the lack of environment-facing mitigation actions included in existing AMR action plans is likely a function of our poor fundamental understanding of many of the key issues. Here, we aim to present the problem with AMR in the environment through the lens of an environmental regulator, using the Environment Agency (England’s regulator) as an example from which parallels can be drawn globally. The issues that are pertinent to environmental regulators are drawn out to answer: What are the drivers and pathways of AMR? How do these relate to the normal work, powers and duties of environmental regulators? What are the knowledge gaps that hinder the delivery of environmental protection from AMR? We offer several thought experiments for how different mitigation strategies might proceed. We conclude that: (1) AMR Action Plans do not tackle all the potentially relevant pathways and drivers of AMR in the environment; and (2) AMR Action Plans are deficient partly because the science to inform policy is lacking and this needs to be addressed.

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Section: Relevance Of Amr To Environmental Regulators?mentioning

confidence: 99%

Review of Antimicrobial Resistance in the Environment and Its Relevance to Environmental Regulators

et al. 2016

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“…Numerous studies have reported the concentrations of antibiotics ranged from several ng per liter to hundreds of μg per liter in various environmental compartments, such as hospital sewage, municipal sewage, surface waters, groundwater, and seawater (Brown et al, 2006;Kümmerer, 2009;Chang et al, 2010;Rodriguez-Mozaz et al, 2015;Yao et al, 2015Yao et al, , 2017Chen et al, 2015a, b;Ngumba et al, 2016;Sui et al, 2017). The antibiotic burden in water can result in direct toxicity to animals (Wollenberger et al, 2000;Wang et al, 2014;Yan et al, 2016) and plants (Migliore et al, 2003;Pan and Chu, 2016), but more importantly, they can induce antibiotic-resistant bacteria or genes, which increase health and ecological hazards through food chains, even at low concentrations (Wellington et al, 2013;Ye et al, 2016;Sharma et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Occurrence and ecological hazard assessment of selected antibiotics in the surface waters in and around Lake Honghu, China

Wang

Yang

et al. 2017

Science of The Total Environment

206

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“…While most other studies on antibiotic‐effects on plants used much higher concentrations (Hillis, Fletcher, Solomon, & Sibley, 2011; Jin, Chen, Sun, Zhou, & Liu, 2009; Li et al., 2011; Pan & Chu, 2016; Yang et al., 2010; Ziolkowska, Piotrowicz‐Cieslak, Margas, Adomas, & Nalecz‐Jawecki, 2015), we used comparatively low concentrations, which were also detected in agricultural soils (Thiele‐Bruhn, 2003). Our results show that antibiotics, even in these low concentrations, affect plant element content, with similar effects expected for real‐world scenarios.…”

Section: Discussionmentioning

confidence: 99%

“…Species‐specific results have been shown by other studies on antibiotic‐induced responses, for example, on germination (Liu et al., 2009; Minden et al., 2017), postgerminative development (Migliore et al., 1997), root elongation (Pan & Chu, 2016), root and shoot lengths (Hillis et al., 2011), or bioaccumulation (Migliore, Brambilla, Cozzolino, & Gaudio, 1995). …”

Section: Discussionmentioning

confidence: 99%

Antibiotic‐induced effects on scaling relationships and on plant element contents in herbs and grasses

Minden

Schnetger

Pufal

et al. 2018

Ecology and Evolution

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Plant performance is correlated with element concentrations in plant tissue, which may be impacted by adverse chemical soil conditions. Antibiotics of veterinary origin can adversely affect plant performance. They are released to agricultural fields via grazing animals or manure, taken up by plants and may be stored, transformed or sequestered by plant metabolic processes. We studied the potential effects of three antibiotics (penicillin, sulfadiazine, and tetracycline) on plant element contents (macro‐ and microelements). Plant species included two herb species (Brassica napus and Capsella bursa‐pastoris) and two grass species (Triticum aestivum and Apera spica‐venti), representing two crop species and two noncrop species commonly found in field margins, respectively. Antibiotic concentrations were chosen as to reflect in vivo situations, that is, relatively low concentrations similar to those detected in soils. In a greenhouse experiment, plants were raised in soil spiked with antibiotics. After harvest, macro‐ and microelements in plant leaves, stems, and roots were determined (mg/g). Results indicate that antibiotics can affect element contents in plants. Penicillin exerted the greatest effect both on element contents and on scaling relationships of elements between plant organs. Roots responded strongest to antibiotics compared to stems and leaves. We conclude that antibiotics in the soil, even in low concentrations, lead to low‐element homeostasis, altering the scaling relationships between roots and other plant organs, which may affect metabolic processes and ultimately the performance of a plant.

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Phytotoxicity of veterinary antibiotics to seed germination and root elongation of crops

Cited by 190 publications

References 39 publications

Review of Antimicrobial Resistance in the Environment and Its Relevance to Environmental Regulators

Review of Antimicrobial Resistance in the Environment and Its Relevance to Environmental Regulators

Occurrence and ecological hazard assessment of selected antibiotics in the surface waters in and around Lake Honghu, China

Antibiotic‐induced effects on scaling relationships and on plant element contents in herbs and grasses

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