Phytotoxicity of ionic, micro- and nano-sized iron in three plant species

Libralato, Giovanni; Devoti, A. Costa; Zanella, Michela; Sabbioni, E.; Mičetić, Ivan; Manodori, Laura; Pigozzo, Andrea; Manenti, S.; Groppi, F.; Ghirardini, Annamaria Volpi

doi:10.1016/j.ecoenv.2015.07.024

Cited by 96 publications

(37 citation statements)

References 43 publications

(52 reference statements)

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“…Although the nanotoxicological knowledge of Fe 0 NPs is growing, [22][23][24][25] toxicity-based-toxicokinetic (TBTK)/toxicodynamic (TD) assessments describing the fate and behavior of Fe 0 NPs in living organisms are not well understood and remain a substantial challenge. TBTK/TD modeling is a robust mechanistic approach enabling integration of toxic effects on multiple endpoints over time.…”

Section: Introductionmentioning

confidence: 99%

Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in <em>Caenorhabditis elegans</em>

Yang¹,

Lin²,

Liao³

2017

IJN

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Elucidating the relationships between the toxicity-based-toxicokinetic (TBTK)/toxicodynamic (TD) properties of engineered nanomaterials and their nanotoxicity is crucial for human health-risk analysis. Zerovalent iron (Fe 0 ) nanoparticles (NPs) are one of the most prominent NPs applied in remediating contaminated soils and groundwater. However, there are concerns that Fe 0 NP application contributes to long-term environmental and human health impacts. The nematode Caenorhabditis elegans is a surrogate in vivo model that has been successfully applied to assess the potential nanotoxicity of these nanomaterials. Here we present a TBTK/TD approach to appraise bioaccumulation and nanotoxicity of Fe 0 NPs in C. elegans . Built on a present C. elegans bioassay with estimated TBTK/TD parameters, we found that average bioconcentration factors in C. elegans exposed to waterborne and food-borne Fe 0 NPs were ~50 and ~5×10 −3 , respectively, whereas 10% inhibition concentrations for fertility, locomotion, and development, were 1.26 (95% CI 0.19–5.2), 3.84 (0.38–42), and 6.78 (2.58–21) μg·g −1 , respectively, implicating that fertility is the most sensitive endpoint in C. elegans . Our results also showed that biomagnification effects were not observed in waterborne or food-borne Fe 0 NP-exposed worms. We suggest that the TBTK/TD assessment for predicting NP-induced toxicity at different concentrations and conditions in C. elegans could enable rapid selection of nanomaterials that are more likely to be nontoxic in larger animals. We conclude that the use of the TBTK/TD scheme manipulating C. elegans could be used for rapid evaluation of in vivo toxicity of NPs or for drug screening in the field of nanomedicine.

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Section: Introductionmentioning

confidence: 99%

Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in <em>Caenorhabditis elegans</em>

Yang¹,

Lin²,

Liao³

2017

IJN

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“…The accumulation of iron NMs inside the tissue was observed in longitudinal sections of roots ( Figure 33). However, the NMs did not enter the palisade cells or the xylem, as shown in transverse sections [64]. [64]).…”

Section: Iron Nanomaterialsmentioning

confidence: 90%

“…However, the NMs did not enter the palisade cells or the xylem, as shown in transverse sections [64]. [64]).…”

Section: Iron Nanomaterialsmentioning

confidence: 90%

“…• Disadvantages long testing periods: 14-28 days; the analysis of NM content of plants may imply the use of special apparatus like ICP-MS [61]; special techniques like the scanning electron microscopy-cathodoluminescence technique may be used for the analysis of NM content of agar paste [61]; the biological effects determined could depend on the species selected for the assay [64].…”

Section: Terrestrial Plants Used For Ecotoxicity Testing Of Nanomatermentioning

confidence: 99%

“…These NMs are also suitable for immobilization and degradation of soil contaminants due to their high specific surface area and high reactivity. Thus, their use in soil clean-up purposes could cause potential hazards to soil organisms and macrophytes [64].…”

Section: Iron Nanomaterialsmentioning

confidence: 99%

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Evaluation of Ecotoxicology Assessment Methods of Nanomaterials and Their Effects

Boros

Ostafe

2020

Nanomaterials

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This paper describes the ecotoxicological effects of nanomaterials (NMs) as well as their testing methods. Standard ecotoxicity testing methods are applicable to nanomaterials as well but require some adaptation. We have taken into account methods that meet several conditions. They must be properly researched by a minimum of ten scientific articles where adaptation of the method to the NMs is also presented; use organisms suitable for simple and rapid ecotoxicity testing (SSRET); have a test period shorter than 30 days; require no special equipment; have low costs and have the possibility of optimization for high-throughput screening. From the standard assays described in guidelines developed by organizations such as Organization for Economic Cooperation and Development and United States Environmental Protection Agency, which meet the required conditions, we selected as methods adaptable for NMs, some methods based on algae, duckweed, amphipods, daphnids, chironomids, terrestrial plants, nematodes and earthworms. By analyzing the effects of NMs on a wide range of organisms, it has been observed that these effects can be of several categories, such as behavioral, morphological, cellular, molecular or genetic effects. By comparing the EC50 values of some NMs it has been observed that such values are available mainly for aquatic ecotoxicity, with the most sensitive test being the algae assay. The most toxic NMs overall were the silver NMs.

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Toxicological Concerns of Nanomaterials in Agriculture

Rienzie

Adassooriya

2021

Nanotechnology in Plant Growth Promotion and Protection

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Phytotoxicity of ionic, micro- and nano-sized iron in three plant species

Cited by 96 publications

References 43 publications

Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in <em>Caenorhabditis elegans</em>

Toxicity-based toxicokinetic/toxicodynamic assessment of bioaccumulation and nanotoxicity of zerovalent iron nanoparticles in <em>Caenorhabditis elegans</em>

Evaluation of Ecotoxicology Assessment Methods of Nanomaterials and Their Effects

Toxicological Concerns of Nanomaterials in Agriculture

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