Phytotoxic Chlorophyll Derivatives from Petrorhagia velutina (Guss.) Ball et Heyw Leaves

D’Abrosca, Brigida; Scognamiglio, Monica; Tsafantakis, Nikolaos; Fiorentino, Antonio; Monaco, Pietro

doi:10.1177/1934578x1000500124

Cited by 6 publications

(4 citation statements)

References 15 publications

(16 reference statements)

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“…Plant species of the order Brassicaceae accumulate sinapoylglucose; additionally, acylated sinapoylglucose has also been detected in Brassica napus seeds [42]. Polyacylated acyl-glucose has been found in the leaves of Rhus typhina and dimeric p -coumaroylglucose has been extracted from Petrorhagia velutina [43,44]. Some studies have also reported other acyl-glucoses that are not derived from HCAs or HBAs.…”

Section: Acyl-glucoses As Potential Intermediates For Secondary Mementioning

confidence: 99%

The Role of Acyl-Glucose in Anthocyanin Modifications

et al. 2014

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Abstract:Higher plants can produce a wide variety of anthocyanin molecules through modification of the six common anthocyanin aglycons that they present. Thus, hydrophilic anthocyanin molecules can be formed and stabilized by glycosylation and acylation. Two types of glycosyltransferase (GT) and acyltransferase (AT) have been identified, namely cytoplasmic GT and AT and vacuolar GT and AT. Cytoplasmic GT and AT utilize UDP-sugar and acyl-CoA as donor molecules, respectively, whereas both vacuolar GT and AT use acyl-glucoses as donor molecules. In carnation plants, vacuolar GT uses aromatic acyl-glucoses as the glucose donor in vivo; independently, vacuolar AT uses malylglucose, an aliphatic acyl-glucose, as the acyl-donor. In delphinium and Arabidopsis, p-hydroxybenzoylglucose and sinapoylglucose are used in vivo as bi-functional donor molecules by vacuolar GT and AT, respectively. The evolution of these enzymes has allowed delphinium and Arabidopsis to utilize unique donor molecules for production of highly modified anthocyanins.

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Section: Acyl-glucoses As Potential Intermediates For Secondary Mementioning

confidence: 99%

The Role of Acyl-Glucose in Anthocyanin Modifications

et al. 2014

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“…6,7 Recently, we undertook the phytochemical study of Petrorhagia Velutina, a Eurimediterranean herb, belonging to the Caryophyllaceae family, typical of woodland and macchia vegetation. 8,9 In the present paper, the characterization of eight flavonoid C-glycosides, including three new analogues, and the evaluation of their antiproliferative activity against human hepatoblastoma cancer cell line HepG2 are reported.…”

mentioning

confidence: 99%

“…In the search for new bioactive secondary metabolites from natural sources, we reported the isolation and characterization of new antioxidant and antiproliferative phytochemicals from Mediterranean plants. , Recently, we undertook the phytochemical study of Petrorhagia velutina , a Eurimediterranean herb, belonging to the Caryophyllaceae family, typical of woodland and macchia vegetation. , In the present paper, the characterization of eight flavonoid C -glycosides, including three new analogues, and the evaluation of their antiproliferative activity against human hepatoblastoma cancer cell line HepG2 are reported.…”

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confidence: 99%

Spectroscopic Characterization and Antiproliferative Activity on HepG2 Human Hepatoblastoma Cells of Flavonoid C-Glycosides from Petrorhagia velutina

et al. 2010

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Eight flavonoid C-glycosides, including three new analogues, have been isolated from leaf and root methanolic extracts of Petrorhagia velutina, a Mediterranean herbaceous plant. The antiproliferative activity against human hepatoblastoma cancer cell line HepG2 has been analyzed by the MTT (3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide) test. Isoorientin (4) significantly reduces the proliferation of HepG2 cells as determined by the complete conversion of the tetrazolium probe into formazan after 48 h of exposure.

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“…The 13 C NMR spectrum exhibited 36 carbon signals and the presence of an aldehyde was additionally confirmed at 187.8 ppm. Based on spectroscopic evidence and comparison with earlier literature, compound 2 was identified as ethyl pheophorbide b [30].…”

Section: Isolation and Identification Of Ethyl Pheophorbides A And Bmentioning

confidence: 89%

Antiviral Activities of Ethyl Pheophorbides a and b Isolated from Aster pseudoglehnii against Influenza Viruses

et al. 2022

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Screening of the antiviral and virucidal activities of ethanol extracts from plants endemic to the Republic of Korea revealed the inhibitory activity of a 70% ethanol extract of the whole plant of A. pseudoglehnii (APE) against influenza virus infection. Two chlorophyll derivatives, ethyl pheophorbides a and b, isolated as active components of APE, exerted virucidal effects with no evident cytotoxicity. These compounds were effective only under conditions of direct incubation with the virus, and exerted no effects on the influenza A virus (IAV) surface glycoproteins hemagglutinin (HA) and neuraminidase (NA). Interestingly, virucidal activities of ethyl pheophorbides a and b were observed against enveloped but not non-enveloped viruses, suggesting that these compounds act by affecting the integrity of the viral membrane and reducing infectivity.

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Phytotoxic Chlorophyll Derivatives from Petrorhagia velutina (Guss.) Ball et Heyw Leaves

Cited by 6 publications

References 15 publications

The Role of Acyl-Glucose in Anthocyanin Modifications

The Role of Acyl-Glucose in Anthocyanin Modifications

Spectroscopic Characterization and Antiproliferative Activity on HepG2 Human Hepatoblastoma Cells of Flavonoid C-Glycosides from Petrorhagia velutina

Antiviral Activities of Ethyl Pheophorbides a and b Isolated from Aster pseudoglehnii against Influenza Viruses

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