Phytotherapy using blueberry leaf polyphenols to alleviate non-alcoholic fatty liver disease through improving mitochondrial function and oxidative defense

Li, Zheng; Zhang, Huixia; Li, Yan; Chen, Hongwei; Wang, Caiyun; Wong, Vincent Kam Wai; Jiang, Zhi‐Hong; Zhang, Wei

doi:10.1016/j.phymed.2020.153209

Cited by 38 publications

(27 citation statements)

References 30 publications

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“…Vitamin E has shown promising data but without significant benefit in fibrosis improvement (162). Several natural polyphenols and n-3 PUFA supplementation provided with a number of antioxidant, antiobesity, and anti-inflammatory effects could have potential in NAFLD prevention and treatment by acting on its multifactorial pathogenetic components, but also here data either to support or refuse their use are insufficient (115,116).…”

Section: Discussionmentioning

confidence: 99%

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Oxidative Stress in Non-alcoholic Fatty Liver Disease. An Updated Mini Review

et al. 2021

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Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple factors, which may partly explain why it remains still orphan of an adequate therapeutic strategy. Herein we focus on the interplay between oxidative stress (OS) and the other causal pathogenetic factors. Different reactive oxygen species (ROS) generators contribute to NAFLD inflammatory and fibrotic progression, which is quite strictly linked to the lipotoxic liver injury from fatty acids and/or a wide variety of their biologically active metabolites in the context of either a two-hit or a (more recent) multiple parallel hits theory. An antioxidant defense system is usually able to protect hepatic cells from damaging effects caused by ROS, including those produced into the gastrointestinal tract, i.e., by-products generated by usual cellular metabolic processes, normal or dysbiotic microbiota, and/or diet through an enhanced gut–liver axis. Oxidative stress originating from the imbalance between ROS generation and antioxidant defenses is under the influence of individual genetic and epigenetic factors as well. Healthy diet and physical activity have been shown to be effective on NAFLD also with antioxidant mechanisms, but compliance to these lifestyles is very low. Among several considered antioxidants, vitamin E has been particularly studied; however, data are still contradictory. Some studies with natural polyphenols proposed for NAFLD prevention and treatment are encouraging. Probiotics, prebiotics, diet, or fecal microbiota transplantation represent new therapeutic approaches targeting the gut microbiota dysbiosis. In the near future, precision medicine taking into consideration genetic or environmental epigenetic risk factors will likely assist in further selecting the treatment that could work best for a specific patient.

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Section: Discussionmentioning

confidence: 99%

“…-Among polyphenols, blueberry leaf polyphenols appear to have a positive effect on hepatic mitochondrial dysfunction and redox homeostasis, whereas bergamot polyphenolic formulation seems to improve IR, hepatocellular ballooning, inflammation, and fibrosis (115,116).…”

Section: Clinical Trials Of Vitamin E For Nafld: Vitamin E In the CLImentioning

confidence: 99%

Oxidative Stress in Non-alcoholic Fatty Liver Disease. An Updated Mini Review

et al. 2021

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“…Existing data showed that in the liver cells of NAFLD patients, decreased mitochondrial membrane potential (MMP) leads to decreased ATP‐production and elevated mitochondrial ROS‐production. This process will eventually cause the deposition of lipids in the liver, liver injury, oxidative stress, and cell apoptosis (Li et al., 2020). At the same time, NAFLD can cause an elevation in mitochondrial function that covers the increased demand for ATP caused by elevated lipogenesis and gluconeogenesis (Shum et al., 2020).…”

Section: Introductionmentioning

confidence: 99%

Major royal jelly proteins prevents NAFLD by improving mitochondrial function and lipid accumulation through activating the AMPK / SIRT3 pathway in vitro

Zhang

Zhou

et al. 2021

Journal of Food Science

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Nonalcoholic fatty liver disease (NAFLD) is a metabolic syndrome, whose main characteristics are excessive lipid accumulation and oxidative stress. Major royal jelly proteins (MRJPs) is a kind of water‐soluble protein, which is abundant in royal jelly (RJ). The aim of this study was to evaluate the effect of MRJPs on lipid accumulation and oxidative stress of liver cells. Here, we first optimized the conditions for extracting MRJPs from RJ and identified the extraction effect and product by SDS‐PAGE. Then, we used oleic acid (OA) of 1.0 mM to induce hepatocytes for 24 hr to establish a stable cell models of lipid accumulation, and we found that pre‐administration (24 hr) of MRJPs (0.2, 0.5, and 1.0 g/L) could significantly reduce the lipid drop content and triglyceride level in the model cells, and simultaneously reduce the alanine aminotransferase and aspertate aminotransferase levels in the cell culture supernatant. In addition, pre‐incubation (24 hr) with MRJPs (0.2, 0.5, and 1.0 g/L) could restore superoxide dismutase (SOD) level and mitochondrial membrane potential as compared with OA group. Furthermore, MRJPs administration significantly upregulated the expression of Silent Information Regulator 2 Associated Protein 3, mitochondrial superoxide dismutase (SOD2), and cytochrome c oxidase subunit IV in OA‐treated HepG2 cells. The study for the first time provides evidences on the lipid‐lowering effect of MRJPs at the cellular level, which can further provide support for the development and application of polypeptide drugs in the future, and can also provide a choice for the prevention and treatment of liver metabolic diseases represented by NAFLD. Practical Application Our study proved that MRJPs had substantial preventing effect on OA‐induced lipid accumulation and mitochondrial dysfunction in HepG2 cells. This research can further provide theoretical support for the development and application of peptide drugs in the future. Besides, it can not only further broaden our understanding of NAFLD and other diseases, but also provide ideas for research on oxidative stress and lipid accumulation in the body.

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“…Algunas de estas plantas son ricas en moléculas con potencial biotecnológico, como los flavonoides. El presente estudio evaluó el perfil bioactivo in silico de tres flavonoides: tilirosida (Kaempferol-3-O-β-D-(6 "-Ep-cumaril) glucopiranósido), Pg-1 (5,7-dihidroxi-3,8, 4'-trimetoxi) y vitexina (5,7,4'-trihidroxiflavona-8-C-β-glucopiranósido). Se abordó la acción predictiva antineoplásica sobre órganos del aparato gastrointestinal y urinario y la actividad protectora frente a enfermedades crónicas (diabetes, hipertensión, cataratas, osteoporosis, hipercolesterolemia, disfunción tiroidea y enfermedades renales).…”

Section: Introductionunclassified

“…Os fitoterápicos, que são largamente usados na cura de doenças ou no alívio de seus sintomas, têm uma eficácia terapêutica baseada na ação combinada de vários compostos ativos, que buscam reduzir a ocorrência de toxicidade e simultaneamente proporcionar melhorias nas condições de vida, evitando o agravamento de problemas de saúde pré-existentes e efeitos colaterais oriundos de associações medicamentosas. Geralmente, esses efeitos acometem pacientes mais idosos portadores de doenças crônicas, fazendo com que terapias de menor impacto fisiológico sejam mais benéficas em tratamentos com uso prolongado de medicamentos 4,5 .…”

Section: Introductionunclassified

Potencial bioativo dos flavonoides vitexina, tilirosideo e 5,7-dihidroxi-3,8,4'-trimetoxi no tratamento de doenças crônicas e neoplasias do sistema gastrointestinal e excretor

et al. 2021

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As doenças crônicas representam o principal grupo de doenças com elevados índices de mortalidade. Dessa forma, a utilização de plantas medicinais por adultos no tratamento de enfermidades ou amenização de seus sintomas é uma prática alternativa que vem sendo adotada mundialmente. O avanço científico e a modernização contribuem substancialmente para descoberta de substâncias naturais para produção de novos fármacos, com uma grande possibilidade de terem menor grau de toxicidade. Algumas dessas plantas são ricas em moléculas dotadas de potencial biotecnológico, como os flavonoides. O presente estudo avaliou o perfil bioativo in silico de três flavonoides: tilirosídeo (Kaempferol-3-O-β-D-(6”-Ep-coumaril) glucopiranosideo), Pg-1 (5,7-dihidroxi-3,8,4'-trimetoxi) e vitexina (5,7,4'-trihidroxiflavona-8-C-β-glucopiranosideo). Foi abordada a ação preditiva antineoplásica em órgãos do sistema gastrointestinal e urinário e a atividade protetora contra doenças crônicas (diabetes, hipertensão, catarata, osteoporose, hipercolesterolemia, disfunção de tireoide e doenças renais). O estudo demonstrou que a vitexina apresentou efeito antidiabetes (tipo II) e antihipercolesterolemia; o tilirosideo, atividade antidiabetes (tipo I), antihipercolesterolemia, antihipóxico, antinefrítico e antiosteoporótico, e o Pg-1, ação anticatarata, anti-hipertensiva e antitireoidiana. A avaliação da probabilidade do potencial antineoplásico mostrou que a vitexina possui melhor potencial anticâncer no pâncreas, estômago, bexiga e rim, e efeito anti - Helicobacter pylori. O Pg-1 apresentou maior atividade anticâncer no cólon e na região cólon-retal. O tilirosideo, apesar de exibir menor efeito em relação às demais substâncias, evidenciou atividade satisfatória anticâncer pancreática e cólon-retal. Portanto, estas moléculas podem tornar-se importantes candidatas a fármacos naturais como recurso terapêutico de combate a doenças crônicas e ao câncer do sistema gastrointestinal e urinário.

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Phytotherapy using blueberry leaf polyphenols to alleviate non-alcoholic fatty liver disease through improving mitochondrial function and oxidative defense

Cited by 38 publications

References 30 publications

Oxidative Stress in Non-alcoholic Fatty Liver Disease. An Updated Mini Review

Oxidative Stress in Non-alcoholic Fatty Liver Disease. An Updated Mini Review

Major royal jelly proteins prevents NAFLD by improving mitochondrial function and lipid accumulation through activating the AMPK / SIRT3 pathway in vitro

Potencial bioativo dos flavonoides vitexina, tilirosideo e 5,7-dihidroxi-3,8,4'-trimetoxi no tratamento de doenças crônicas e neoplasias do sistema gastrointestinal e excretor

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