Phytotherapeutics in cancer invasion and metastasis

Salehi, Bahare; Zucca, Paolo; Sharifi‐Rad, Mehdi; Pezzani, Raffaele; Rajabi, Sadegh; Setzer, William N.; Varoni, Elena Maria; Kobarfard, Farzad; Sharifi‐Rad, Javad

doi:10.1002/ptr.6087

Cited by 101 publications

(63 citation statements)

References 270 publications

(321 reference statements)

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“…In recent years, the interest towards induction of apoptosis as a strategy to produce antitumor drugs has increased (Mishra et al, ). Finding an antitumor drug with an apoptosis‐inducing agent and specificity for tumor cells may be ideal (Salehi et al, ). Cytotoxicity of CV towards a human non‐small‐cell lung carcinoma cell line (A549) was reported by Koparal and Zeytinoglu ().…”

Section: Resultsmentioning

confidence: 99%

Carvacrol and human health: A comprehensive review

Sharifi‐Rad

Varoni

Iriti

et al. 2018

Phytotherapy Research

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365

228

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Carvacrol (CV) is a phenolic monoterpenoid found in essential oils of oregano (Origanum vulgare), thyme (Thymus vulgaris), pepperwort (Lepidium flavum), wild bergamot (Citrus aurantium bergamia), and other plants. Carvacrol possesses a wide range of bioactivities putatively useful for clinical applications such antimicrobial, antioxidant, and anticancer activities. Carvacrol antimicrobial activity is higher than that of other volatile compounds present in essential oils due to the presence of the free hydroxyl group, hydrophobicity, and the phenol moiety. The present review illustrates the state-of-the-art studies on the antimicrobial, antioxidant, and anticancer properties of CV. It is particularly effective against food-borne pathogens, including Escherichia coli, Salmonella, and Bacillus cereus. Carvacrol has high antioxidant activity and has been successfully used, mainly associated with thymol, as dietary phytoadditive to improve animal antioxidant status. The anticancer properties of CV have been reported in preclinical models of breast, liver, and lung carcinomas, acting on proapoptotic processes. Besides the interesting properties of CV and the toxicological profile becoming definite, to date, human trials on CV are still lacking, and this largely impedes any conclusions of clinical relevance.

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Section: Resultsmentioning

confidence: 99%

Carvacrol and human health: A comprehensive review

Sharifi‐Rad

Varoni

Iriti

et al. 2018

Phytotherapy Research

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365

228

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“…In this context, thyme possesses numerous compounds and natural antioxidants, which have enormous potential to combat microorganism infections, to enhance immunity, and to be used in therapeutic and management intervention against cancer due to their pharmacological activities (Bagheri, Mirzaei, Mehrabi, & Sharifi‐Rad, ; Salehi et al, ; Sharifi‐Rad, Sureda, et al, ; Sharifi‐Rad, Mnayer, et al, ; Stojanović‐Radić, Pejčić, Stojanović, Sharifi‐Rad, Stanković, ). Thymol and carvacrol are two of its active compounds as commented above.…”

Section: Resultsmentioning

confidence: 99%

Thymol, thyme, and other plant sources: Health and potential uses

Salehi

Mishra

Shukla

et al. 2018

Phytotherapy Research

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351

207

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Thymol is a naturally occurring phenol monoterpene derivative of cymene and isomer of carvacrol. Thymol (10-64%) is one of the major constituent of essential oils of thyme (Thymus vulgaris L., Lamiaceae), a medicinal plant with several therapeutic properties. This plant, native to Mediterranean regions, is commonly used as a culinary herb and also with a long history of use for different medicinal purposes. Nowadays, thymol and thyme present a wide range of functional possibilities in pharmacy, food, and cosmetic industry. The interest in the formulation of pharmaceuticals, nutraceuticals, and cosmeceuticals based on thymol is due to several studies that have evaluated the potential therapeutic uses of this compound for the treatment of disorders affecting the respiratory, nervous, and cardiovascular systems. Moreover, this compound also exhibits antimicrobial, antioxidant, anticarcinogenesis, anti-inflammatory, and antispasmodic activities, as well as a potential as a growth enhancer and immunomodulator. In the present review, these bioactivities have been covered because some of them can contribute to explain the ethnopharmacology of thymol and its main source, T. vulgaris. Other important aspects about thymol are discussed: its toxicity and bioavailability, metabolism, and distribution in animals and humans.

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“…Plant products, their enriched-derived extracts, and their isolated bioactive molecules have been increasingly studied due their renowned health attributes, largely used in folk medicine over centuries for multiple purposes [1,2,3,4,5,6,7,8,9]. Indeed, phytomedicine is garnering much attention among the medical and scientific communities [10,11,12].…”

Section: Introductionmentioning

confidence: 99%

Phytochemicals in Helicobacter pylori Infections: What Are We Doing Now?

Salehi

Sharopov

Martorell

et al. 2018

IJMS

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In this critical review, plant sources used as effective antibacterial agents against Helicobacter pylori infections are carefully described. The main intrinsic bioactive molecules, responsible for the observed effects are also underlined and their corresponding modes of action specifically highlighted. In addition to traditional uses as herbal remedies, in vitro and in vivo studies focusing on plant extracts and isolated bioactive compounds with anti-H. pylori activity are also critically discussed. Lastly, special attention was also given to plant extracts with urease inhibitory effects, with emphasis on involved modes of action.

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Phytotherapeutics in cancer invasion and metastasis

Cited by 101 publications

References 270 publications

Carvacrol and human health: A comprehensive review

Carvacrol and human health: A comprehensive review

Thymol, thyme, and other plant sources: Health and potential uses

Phytochemicals in Helicobacter pylori Infections: What Are We Doing Now?

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