Phytotherapeutic applications of alkaloids in treating breast cancer

Rampogu, Shailima; Balasubramaniyam, Thananjeyan; Lee, Joon‐Hwa

doi:10.1016/j.biopha.2022.113760

Cited by 19 publications

(10 citation statements)

References 123 publications

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“…Alkaloids are natural compounds with structures containing plant-derived nitrogen arranged in a cyclic structure, comprising almost 20 % of plant secondary metabolites. [125] Among them, three alkaloids in total were detected in Borago officinalis: sanguinarine and berberine in the methanolic extract of B. officinalis flowers, as well as an alkaloid derived from aspidospermine with anti-amyloid properties in the chloroform extract of B. officinalis leaves, named 1-acetyl-19,21-epoxy-15,16-dimethoxyaspidospermidine-17-ol. Resonance Spectroscopy; SPME-GC/MS: Solid-Phase Microextraction Gas Chromatography/Mass Spectrometry; GC-FID: Gas Chromatography wit Flame Ionization Detection; GC-MS: Gas Chromatography-Mass Spectrometry; GC-MS/MS: Gas Chromatography-Tandem Mass Spectrometry…”

Section: Alkaloidsmentioning

confidence: 99%

“…Alkaloids are natural compounds with structures containing plant‐derived nitrogen arranged in a cyclic structure, comprising almost 20 % of plant secondary metabolites [125] . Among them, three alkaloids in total were detected in Borago officinalis : sanguinarine and berberine in the methanolic extract of B. officinalis flowers, as well as an alkaloid derived from aspidospermine with anti‐amyloid properties in the chloroform extract of B. officinalis leaves, named 1‐acetyl‐19,21‐epoxy‐15,16‐dimethoxyaspidospermidine‐17‐ol.…”

Section: Phytochemistrymentioning

confidence: 99%

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Borago Officinalis L.: A Review Oon Extraction, Phytochemical, and Pharmacological Activities

Slama,

Slougui,

Benaissa

et al. 2024

Chemistry & Biodiversity

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Borago officinalis L., an annual herb belonging to the Boraginaceae family, is used in the traditional medical practices of various countries and for multiple treatments, including respiratory disorders, colds, influenza, diarrhea, cramps, inflammation, palpitation, hypertension menopause, and post‐menopausal symptoms. Its pharmacological properties and biological activities ‐ among them antioxidant, antimicrobial, anticancer, anti‐inflammatory, insecticidal, antigenotoxic, and anti‐obesity activity ‐ were demonstrated in vitro and in vivo and are related to its rich content of bioactive compounds (mainly phenolic acids, flavonoids, anthocyanins, alkaloids, and terpenes) extracted from various parts of B. officinalis including leaves, flowers, seeds, and roots. This review summarizes all updated information on applied extraction processes, phytochemistry, pharmacology, and toxicity of B. officinalis.

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Section: Alkaloidsmentioning

confidence: 99%

Section: Phytochemistrymentioning

confidence: 99%

Borago Officinalis L.: A Review Oon Extraction, Phytochemical, and Pharmacological Activities

Slama,

Slougui,

Benaissa

et al. 2024

Chemistry & Biodiversity

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“…Alkaloids are a class of compounds with various therapeutic effects that play a massive role in treating diseases ( Peng et al, 2019 ; Bai et al, 2021 ; Rampogu et al, 2022 ). However, according to the literature, alkaloids rarely show potential in treating PCOS.…”

Section: Alkaloidsmentioning

confidence: 99%

Advancements in lead therapeutic phytochemicals polycystic ovary syndrome: A review

Erdan

Jiang²,

Chen³

et al. 2023

Front. Pharmacol.

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Polycystic ovary syndrome (PCOS) is one of the most common endocrine diseases in women of reproductive age and features complex pathological symptoms and mechanisms. Existing medical treatments have, to some extent, alleviated the deterioration of PCOS. However, these strategies only temporarily control symptoms, with a few side effects and no preventive effect. Phytochemicals extracted from medicinal herbs and plants are vital for discovering novel drugs. In recent years, many kinds of research have proven that phytochemicals isolated from traditional Chinese medicine (TCM) and medicinal plants show significant potential in preventing, alleviating, and treating PCOS. Nevertheless, compared to the abundance of experimental literature and minimal specific-topic reviews related to PCOS, there is a lack of systematic reviews to summarize these advancements in this promising field. Under this background, we systematically document the progress of bioactive phytochemicals from TCM and medicinal plants in treating PCOS, including flavonoids, polyphenols, and alkaloids. According to the literature, these valuable phytochemicals demonstrated therapeutic effects on PCOS supported by in vivo and in vitro experiments, mainly depending on anti-inflammatory, antioxidation, improvement of hormone disorder and insulin resistance (IR), and alleviation of hyperinsulinemia. Based on the current progress, future research directions should emphasize 1) exploring bioactive phytochemicals that potentially mediate bone metabolism for the treatment of PCOS; 2) improving unsatisfactory bioavailability by using advanced drug delivery systems such as nanoparticles and antibody-conjugated drugs, as well as a chemical modification; 3) conducting in-depth research on the pathogenesis of PCOS to potentially impact the gut microbiota and its metabolites in the evolution of PCOS; 4) revealing the pharmacological effects of these bioactive phytochemicals on PCOS at the genetic level; and 5) exploring the hypothetical and unprecedented functions in regulating PCOS by serving as proteolysis-targeting chimeras and molecular glues compared with traditional small molecule drugs. In brief, this review aims to provide detailed mechanisms of these bioactive phytochemicals and hopefully practical and reliable insight into clinical applications concerning PCOS.

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“…Alkaloids are a class of natural substances that have received considerable interest due to their therapeutic potential, including anti-inflammatory, antiviral, and antimicrobial activities. In cancer cells, they can trigger apoptosis and autophagy, reduce tumor size, inhibit cell proliferation, and can be used in combined therapeutic approaches [307,308]. Among the alkaloids, piperine is commonly cited for its antitumor activities in luminal BC.…”

Section: Alkaloids and Catechinsmentioning

confidence: 99%

Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer

da Silva,

Brandão,

Ferreira

et al. 2023

Pharmaceuticals

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Breast cancer (BC) is the most diagnosed cancer worldwide, mainly affecting the epithelial cells from the mammary glands. When it expresses the estrogen receptor (ER), the tumor is called luminal BC, which is eligible for endocrine therapy with hormone signaling blockade. Hormone therapy is essential for the survival of patients, but therapeutic resistance has been shown to be worrying, significantly compromising the prognosis. In this context, the need to explore new compounds emerges, especially compounds of plant origin, since they are biologically active and particularly promising. Natural products are being continuously screened for treating cancer due to their chemical diversity, reduced toxicity, lower side effects, and low price. This review summarizes natural compounds for the treatment of luminal BC, emphasizing the activities of these compounds in ER-positive cells. Moreover, their potential as an alternative to endocrine resistance is explored, opening new opportunities for the design of optimized therapies.

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Phytotherapeutic applications of alkaloids in treating breast cancer

Cited by 19 publications

References 123 publications

Borago Officinalis L.: A Review Oon Extraction, Phytochemical, and Pharmacological Activities

Borago Officinalis L.: A Review Oon Extraction, Phytochemical, and Pharmacological Activities

Advancements in lead therapeutic phytochemicals polycystic ovary syndrome: A review

Tailoring Potential Natural Compounds for the Treatment of Luminal Breast Cancer

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