Phytosynthesis of gold nanoparticles: Characterization, biocompatibility, and evaluation of its osteoinductive potential for application in implant dentistry

Jadhav, Kiran; Jalalpure, Sunil; Deshpande, Swapnil; Jagwani, Satveer; Dhamecha, Dinesh; Jalalpure, Sunil; Karthikeyan, S.; Baheti, Dwarkadas

doi:10.1016/j.msec.2018.08.028

Cited by 63 publications

(36 citation statements)

References 31 publications

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“…Moreover, several studies proved their potential as antimicrobial agents that prevent biofilm formation [28,29]. To date, among metallics' nanomaterials, usage in the area of dentistry silver and gold particles has been successfully engaged [30][31][32]. To the best of our knowledge, this is the first study where core-shell magnetic nanoparticles were proposed and tested as a component of artificial saliva preparation to improve their 3 of 17 antimicrobial activity.…”

Section: Introductionmentioning

confidence: 95%

Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles

Niemirowicz-Laskowska

Mystkowska

Łysik

et al. 2020

IJMS

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Saliva plays a crucial role in oral cavity. In addition to its buffering and moisturizing properties, saliva fulfills many biofunctional requirements, including antibacterial activity that is essential to assure proper oral microbiota growth. Due to numerous extra- and intra-systemic factors, there are many disorders of its secretion, leading to oral dryness. Saliva substitutes used in such situations must meet many demands. This study was design to evaluate the effect of core-shell magnetic nanoparticles (MNPs) adding (gold-coated and aminosilane-coated nanoparticles NPs) on antimicrobial (microorganism adhesion, biofilm formation), rheological (viscosity, viscoelasticity) and physicochemical (pH, surface tension, conductivity) properties of three commercially available saliva formulations. Upon the addition of NPs (20 µg/mL), antibacterial activity of artificial saliva was found to increase against tested microorganisms by 20% to 50%. NPs, especially gold-coated ones, decrease the adhesion of Gram-positive and fungal cells by 65% and Gram-negative bacteria cells by 45%. Moreover, the addition of NPs strengthened the antimicrobial properties of tested artificial saliva, without influencing their rheological and physicochemical properties, which stay within the range characterizing the natural saliva collected from healthy subjects.

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Section: Introductionmentioning

confidence: 95%

Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles

Niemirowicz-Laskowska

Mystkowska

Łysik

et al. 2020

IJMS

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“…Gold nanoparticles (AuNPs) were proved to have the potential to promote the differentiation of hPDLSCs into osteoblasts, increase their osteogenic-related expression of ALP, OCN, COL1, and RUNX2 via MAPK signaling pathway (Niu et al, 2017; Jadhav et al, 2018), while AuNPs incorporated electrospun fiber scaffolds still require more exploration in bone regeneration.…”

Section: Nano-composite Electrospun Fibers In Periodontal Regenerationmentioning

confidence: 99%

Advance of Nano-Composite Electrospun Fibers in Periodontal Regeneration

Lin

2019

Front. Chem.

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Periodontitis is considered to be the main cause of tooth loss, which affects about 15% of the adult population around the world. Scaling and root-planning are the conventional treatments utilized to remove the contaminated tissue and bacteria, but eventually lead to the formation of a poor connection—long junctional epithelium. Therefore, regenerative therapies, such as guided tissue/bone regeneration (GTR/GBR) for periodontal regeneration have been attempted. GTR membranes, acting as scaffolds, create three-dimensional (3D) environment for the guiding of cell attachment, proliferation and differentiation, and play a significant role in periodontal regeneration. Nano-composite scaffolds based on electrospun nanofibers have gained great attention due to their ability to emulate natural extracellular matrix (ECM) that affects cell survival, attachment and reorganization. Promoted protein absorption, cellular reactions, activation of specific gene expression and intracellular signaling, and high surface area to volume ratio are also important properties of nanofibrous scaffolds. Moreover, several bioactive components, such as bioceramics and functional polymers can be easily blended into nanofibrous matrixes to regulate the physical-chemical-biological properties and regeneration abilities. Simultaneously, functional growth factors, proteins and drugs are also incorporated to regulate cellular reactions and even modify the local inflammatory microenvironment, which benefit periodontal regeneration and functional restoration. Herein, the progress of nano-composite electrospun fibers for periodontal regeneration is reviewed, including fabrication methods, compound types and processes, and surface modifications, etc. Significant proof-of-concept examples are utilized to illustrate the results of material characteristics, cellular interactions and periodontal regenerations. Finally, the existing limitations of nano-composite electrospun fibers and the development tendencies in future are also discussed.

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“…Stability of the AgNPs is directly proportional to the magnitude of zeta potential. PDI of synthesized AgNPs (0.2 ± 0.002) was below 0.4 which suggests that the nanoparticles were almost monodisperse in nature.XRD was used to confirm the crystalline or amorphous nature of particles [26]. In the present study, XRD spectrum showed the presence of peaks as per Bragg's reflection from (111) and (200) planes of face center cubic (FCC) crystal structure corresponding to the 2θ value of 38.092,and 44.22 which was under control with the standard values of JCPDS No.…”

Section: Characterization Of Agnpsmentioning

confidence: 57%

Synthesis of Silver Nano particles by Green method Using Vernonia anthelmintica and its Antibacterial activity.

Patave¹,

Siddiqui²

2021

JUSST

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In the modern years, there is an enlarged use of silver nanoparticles (SNPs) in industrial and in the field of medical practice significantly, still, their high risk and lethal outcome have not been studied considerably. The aim behind this research work was to incorporate silver nanoparticles (AgNPs) using Vernonia anthelmintic seeds extract and to assess its antibacterial activity. AgNPs were properly synthesized by the green method and the evolution of AgNPs was firmed by optical color change and UV (ultraviolet) spectroscopy. Synthesized AgNPs were decontaminated and characterized by using Silver Content Estimation-Inductive Coupled Plasma-Atomic Emission Spectroscopy (ICP-AES), Zeta potentiometry, X-ray diffraction (XRD), and transmission electron microscopy (TEM). UV peak at 453.5 nm confirmed the formation of AgNPs. XRD studies disclosed the crystalline nature of AgNPs. ICP-AES studies showed the presence of silver in colloidal dispersion and images were recorded by using HRTEM. Synthesized AgNPs were found to be potent against Staphylococcus aureus, Pseudomonasaeruginosa, E. coli, and MRSA. However, these SNPs are cytotoxic in nature and could obey as a superior antibacterial for therapy of bacterial infections in this period of multiple drug defiance.

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Phytosynthesis of gold nanoparticles: Characterization, biocompatibility, and evaluation of its osteoinductive potential for application in implant dentistry

Cited by 63 publications

References 31 publications

Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles

Antimicrobial and Physicochemical Properties of Artificial Saliva Formulations Supplemented with Core-Shell Magnetic Nanoparticles

Advance of Nano-Composite Electrospun Fibers in Periodontal Regeneration

Synthesis of Silver Nano particles by Green method Using Vernonia anthelmintica and its Antibacterial activity.

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