Phytosterols and inulin-enriched soymilk increases glucagon-like peptide-1 secretion in healthy men: double-blind randomized controlled trial, subgroup study

Abstract

ObjectiveThe study aimed to determine the effect of phytosterols and inulin on plasma glucose, insulin, and GLP-1 levels among healthy men after consuming phytosterols and inulin-enriched soymilk for 8 weeks.ResultsA total of 26 men at least 20 years old were randomly assigned into the 2 g/day of phytosterols and 10 g/day of inulin-enriched soymilk (intervention) group or into the standard soymilk (control) group. In the intervention group, the area under the curve of Glucagon-like peptide-1 secretion increased significantly, compared to its baseline (p = 0.003). The area under the curve of insulin secretion also increased but it did not meet statistical significance (p = 0.118). The area under the curves of plasma glucose were similar between pre- and post-test (p = 0.348). In the control group, none of the primary results significantly changed compared to their baseline levels.Trial registration Thai Clinical Trial Registry: TCTR20160319001 date: March 19, 2016, retrospectively registered.Electronic supplementary materialThe online version of this article (10.1186/s13104-018-3958-5) contains supplementary material, which is available to authorized users.

Analysis of inulin and fructans in Taraxacum officinale L. roots as the main inulin-containing component of antidiabetic herbal mixture

“…Fructans and their representative -inulin have a leading position in the prevention and treatment of diabetes, as confirmed by numerous preclinical and clinical studies (Kietsiriroje et al 2018;Mistry et al 2018;Shang et al 2018;Hoffman et al 2019). Inulin-type fructans help control glycemia in type 2 diabetes and prediabetes by a variety of mechanisms, including by reducing insulin resistance, increasing glucagon-like peptide (GLP-1), and glucagon-like peptide 2 (GLP-2) (Kietsiriroje et al 2018;Paternoster and Falasca 2018). In addition, the hypoglycemic effect of inulin is realized by delaying the rate of gastric emptying, thereby slowing the flow of glucose into the blood and reducing the degree of alimentary hyperglycemia that occurs after meals (Hiel et al 2018).…”

“…The obtained results are an important stage of phytochemical study of antidiabetic herbal mixture and its plant components, because it allows already establish a correlation between biologically active substances and its pharmacodynamics. Fructans and their representative -inulin have a leading position in the prevention and treatment of diabetes, as confirmed by numerous preclinical and clinical studies (Kietsiriroje et al 2018;Mistry et al 2018;Shang et al 2018;Hoffman et al 2019). Inulin-type fructans help control glycemia in type 2 diabetes and prediabetes by a variety of mechanisms, including by reducing insulin resistance, increasing glucagon-like peptide (GLP-1), and glucagon-like peptide 2 (GLP-2) (Kietsiriroje et al 2018;Paternoster and Falasca 2018).…”

“…Inulin as a representative of fructans has hypoglycemic activity due to its ability to increase glucagon-like peptide-1 (GLP-1), which increases the secretion of insulin, inhibits the secretion of glucagon and somatostatin, causes the proliferation and neogenesis of β-cells and increases the response of β-cells to glucose (Kietsiriroje et al 2018;Paternoster and Falasca 2018).…”

Screening study of hypoglycemic activity of the herbal mixtures (message 1)

“…Hypoglycemic activity of the studied herbal mixtures is quite predictable, because they include medicinal plant raw materials containing biologically active substances with proven hypoglycemic action. The main groups of biologically active substances that can lower blood glucose are polysaccharides, especially inulin that has the ability to increase glucagon-like peptide-1 (GLP-1), which increases insulin secretion, inhibits glucagon secretion, causes proliferation and neogenesis of β-cells and increases the response of β-cells to glucose [15,16] In addition, medicinal plants that are part of the studied herbal mixtures contain polyphenolic compounds that exhibit antidiabetic activity by different mechanism of actions, including stimulation of insulin secretion, improvement of pancreatic β-cell functionality, inhibition of gluconeogenesis, intensification of glucose uptake, delay of carbohydrate digestion and glucose absorption, inhibition of protein glycation and insulin fibrillation [17][18][19]. No less important is their antioxidant activity in the treatment and prevention of diabetes and its complications, because they can include suppression of reactive oxygen species (ROS) formation either by inhibition of enzymes or by chelating trace elements involved in free radical generation; scavenging ROS; inhibition the en-zymes involved in ROS generationmicrosomal monooxygenase, glutathione S-transferase, mitochondrial succinoxidase, nicotinamide adenine dinucleotide phosphate (NADH) oxidase, and so forth [19][20][21] Thus, screening study of the herbal mixtures No.…”

Determination of inulin in the herbal mixtures by GC-MS method

“…2018). Inulin has hypoglycemic activity due to its ability to increase glucagon-like peptide-1(GLP-1), which increases the secretion of insulin, inhibits the secretion of glucagon and somatostatin, causes the proliferation and neogenesis of β-cells and increases the response of β-cells to glucose (Kietsiriroje et. al.…”