Phytosterol-enriched milk lowers LDL-cholesterol levels in Brazilian children and adolescents: Double-blind, cross-over trial

Ribas, Simone Augusta; Sichieri, Rosely; Moreira, Annie Seixas Bello; Souza, Daiana de; Cabral, Catia; Gianinni, D.T.; Cunha, Diana Barbosa

doi:10.1016/j.numecd.2017.09.010

Cited by 32 publications

(21 citation statements)

References 20 publications

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“…Finally, the descriptive synthesis was composed of 12 references, whose periods of publication were between 1993 and 2017. [14][15][16][17][18][19][20][21][22][23][24][25] Figure 1 presents the flow diagram of the stages of data search and selection.…”

Section: Resultsmentioning

confidence: 99%

“…All of the selected studies are randomized 15,[17][18][19][20]25 and non-randomized 14,16,[21][22][23][24] clinical trials published in English. Ten of them were carried out in Europe, [14][15][16][17][18][19][20][22][23][24] one in Japan 21 , and one in Brazil.…”

Section: Resultsmentioning

confidence: 99%

“…Ten of them were carried out in Europe, [14][15][16][17][18][19][20][22][23][24] one in Japan 21 , and one in Brazil. 25 All randomized studies had an initial double-blind period. The loss in participants' follow-up was described as: non-adherence to the diet, 22,24,25 personal reasons not related to the study, 17,22,25 changes in pubertal stage, 24 palatability of the product or nausea, 23 difficulty with product intake.…”

Section: Resultsmentioning

confidence: 99%

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Phytosterol supplementation in the treatment of dyslipidemia in children and adolescents: a systematic review

Mantovani

Pugliese

2021

Rev. paul. pediatr.

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Objective: To carry out a systematic review on the effects of phytosterol supplementation on the treatment of dyslipidemia in children and adolescents. Data sources: Review in the SciELO, Lilacs, Bireme, PubMed and Web of Science databases, with no time limit. Descriptors: phytosterols or plant sterols and dyslipidemias, hypercholesterolemia, cholesterol, children, adolescent, in English and Portuguese. The articles included were published in Portuguese, English or Spanish and evaluated the effect of phytosterol supplementation in pediatric patients with dyslipidemia. Documents that involved adults or animals, review papers, case studies and abstracts were excluded. Two authors performed independent extraction of articles. Of 113 abstracts, 19 were read in full and 12 were used in this manuscript. Data synthesis: Phytosterol supplementation to reduce cholesterol levels has been shown to be effective in reducing LDL-cholesterol levels by approximately 10%, with reductions above 10% in LDL-cholesterol levels observed after 8 to 12 weeks of intervention. Studies have not shown significant changes in HDL-cholesterol and triglyceride levels. Based on the absence of adverse effects, its use seems to be safe and of good tolerance in children and adolescents. Conclusions: Phytosterol supplementation seems to be of great therapeutic aid for the treatment of hypercholesterolemia in children and adolescents. Further studies assessing the long-term effect of phytosterol supplementation are necessary.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Phytosterol supplementation in the treatment of dyslipidemia in children and adolescents: a systematic review

Mantovani

Pugliese

2021

Rev. paul. pediatr.

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“…The rationale for such recommendations is not entirely clear. The efficacy of plant sterols to reduce LDL-C during youth has been shown by a considerable number of studies, when both normolipidemic and hyperlipidemic children aged 4-19 years receiving 1.2-3 g/day of plant sterols/stanols showed the same rate of LDL-C reduction as seen in adults (5%-20%) [7,[77][78][79][80][81][82][83]85,86].…”

Section: Plant Sterol Supplementation In Childhoodmentioning

confidence: 97%

Cardiovascular Disease Prevention: The Earlier the Better? A Review of Plant Sterol Metabolism and Implications of Childhood Supplementation

Scolaro

Andrade

Castro

2019

IJMS

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Atherosclerosis is the underlying cause of major cardiovascular events. The development of atherosclerotic plaques begins early in life, indicating that dietary interventions in childhood might be more effective at preventing cardiovascular disease (CVD) than treating established CVD in adulthood. Although plant sterols are considered safe and consistently effective in lowering plasma cholesterol, the health effects of early-life supplementation are unclear. Studies suggest there is an age-dependent effect on plant sterol metabolism: at a younger age, plant sterol absorption might be increased, while esterification and elimination might be decreased. Worryingly, the introduction of low-cholesterol diets in childhood may unintentionally favor a higher intake of plant sterols. Although CVD prevention should start as early as possible, more studies are needed to better elucidate the long-term effects of plant sterol accumulation and its implication on child development.

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“…Phytosterols(PS) are triterpenes, an important component of plant cells, and are commonly found in seeds, vegetable oils and grains. Common in nature are β-sitosterol, campesterol, stigmasterol and ergosterol [1].It has the physiological functions of lowering blood lipid [2,3] , lowering cholesterol [4][5][6] , preventing cardiovascular disease [7],anti-cancer [8], anti-oxidation, scavenging free radicals [9,10], enhancing immunity [11], anti-inflammatory [12,13] and so on. Especially in reducing blood lipids, PS and cholesterol have similar molecular structure, which can competitively inhibit the absorption of cholesterol in the human intestinal tract, thereby reducing blood lipids [14].…”

Section: Introductionmentioning

confidence: 99%

Development and characterization of phytosterol nanoemulsions and self-microemulsifying drug delivery systems

Chuanxun

Xueru

Risheng

2019

Preprint

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The aim of this study is to develop a self microemulsion drug delivery system for phytosterols to improve the solubility and bioavailability. The results showed that the formulation of phytosterol self-microemulsion is: lemon essential oil in oil phase, polyoxyethylene hydrogenated castor oil 40 and Tween 60 in emulsifier, polyethylene glycol 400 in co-emulsifier, Km = 7:3, Kp = 3:1, Ke = 50%. The drug loading of phytosterol self-microemulsion prepared by this method was 87.22 mg/g, encapsulation efficiency was 89.65%, particle size was 48.85nm, potential was -12.863mV. In vitro release experiment showed that the release of phytosterols in microemulsion was more than 90%, and the release curve was in accordance with the first-order kinetics equation. The pharmacokinetic analysis of PSSM synthesized by this method shows that PSSM can increase the bioavailability of PS more than three times, so it is necessary to do more in-depth research on the self-microemulsion delivery system of phytosterols.

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Phytosterol-enriched milk lowers LDL-cholesterol levels in Brazilian children and adolescents: Double-blind, cross-over trial

Cited by 32 publications

References 20 publications

Phytosterol supplementation in the treatment of dyslipidemia in children and adolescents: a systematic review

Phytosterol supplementation in the treatment of dyslipidemia in children and adolescents: a systematic review

Cardiovascular Disease Prevention: The Earlier the Better? A Review of Plant Sterol Metabolism and Implications of Childhood Supplementation

Development and characterization of phytosterol nanoemulsions and self-microemulsifying drug delivery systems

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