Phytosomes—Nanoarchitectures' Promising Clinical Applications and Therapeutics

Pal, Pankaj Kumar; Dave, Vivek S; Paliwal, Sunil; Sharma, Monika; Potdar, Mrugendra B.; Tyagi, Avnica

doi:10.1002/9781119711698.ch9

Cited by 16 publications

(9 citation statements)

References 76 publications

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“…Previous studies have reported that the formulation's % EE depends on drug solubility and bonding interaction leading to matrix formation. Therefore, the present data support results from the earlier studies by Pal et al [23], in which a higher % EE for polyphenols is demonstrated.…”

Section: Determination Of Total Phenolic Content By Use Of Standard C...supporting

confidence: 93%

“…Molecules 2021, 26, x FOR PEER REVIEW 5 of 19 leading to matrix formation. Therefore, the present data support results from the earlier studies by Pal et al [23], in which a higher % EE for polyphenols is demonstrated.…”

Section: Particle Size Polydispersity Index and Zeta Potential Of For...supporting

confidence: 93%

“…This is an indication of high TPC in the extracted Mopp. This assay was important because high total phenolic content has been shown to inhibit initiation and progression of cancer cells by modulating genes, regulating key processes such as growth and development of tumors, oncogenic, angiogenesis, and metastasis [ 23 ]. The perfect number of Mo polyphenols on the phytosome nanoparticles with minimal loss throughout the preparation was reflected by the high % EE as shown in Table 1 .…”

Section: Resultsmentioning

confidence: 99%

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Formulation, Optimization, and Evaluation of Moringa oleifera Leaf Polyphenol-Loaded Phytosome Delivery System against Breast Cancer Cell Lines

et al. 2022

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Moringa oleifera leaf polyphenols (Mopp) were encapsulated with phytosomes to enhance their efficacy on 4T1 cancer cell lines. The Mopp were extracted via microwave-assisted extraction. Moringa oleifera polyphenol-loaded phytosomes (MoP) were prepared with the nanoprecipitation method and characterized using the dynamic light scattering and dialysis membrane techniques. The in vitro cytotoxic and antiproliferative activity were investigated with the (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazole) MTT assay. Acute toxicity was assessed using Swiss albino mice. An MoP particle size of 296 ± 0.29 nm, −40.1 ± 1.19 mV zeta potential, and polydispersity index of 0.106 ± 0.002 were obtained. The total phenolic content was 50.81 ± 0.02 mg GAE/g, while encapsulation efficiency was 90.32 ± 0.11%. The drug release profiles demonstrated biphasic and prolonged subsequent sustained release. In vitro assays indicated MoP had a low cytotoxicity effect of 98.84 ± 0.53 μg/mL, doxorubicin was 68.35 ± 3.508, and Mopp was 212.9 ± 1.30 μg/mL. Moreover, MoP exhibited the highest antiproliferative effect on 4T1 cancer cells with an inhibitory concentration of 7.73 ± 2.87 μg/mL and selectivity index > 3. The results indicated a significant difference (p ≤ 0.001) in MoP when compared to Mopp and doxorubicin. The in vivo investigation showed the safety of MoP at a dose below 2000 mg/kg. The present findings suggest that MoP may serve as an effective and promising formulation for breast cancer drug delivery and therapy.

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Section: Determination Of Total Phenolic Content By Use Of Standard C...supporting

confidence: 93%

Section: Particle Size Polydispersity Index and Zeta Potential Of For...supporting

confidence: 93%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Formulation, Optimization, and Evaluation of Moringa oleifera Leaf Polyphenol-Loaded Phytosome Delivery System against Breast Cancer Cell Lines

et al. 2022

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“…The EE % of the developed NPs offer higher encapsulation of both NPs; however, EG-PC showed higher EE % than BG-PC. A higher EE % also showed better bioavailability of the prepared NPs, which could deliver its potential efficiency when incorporated into biological systems [24] .…”

Section: Methods Validationmentioning

confidence: 87%

Nanophytosome formulation of β-1,3-glucan and Euglena gracilis extract for drug delivery applications

Palol,

Saravanan,

Vuree

et al. 2023

MethodsX

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“…Phytosomes are lipid-based nanocarriers that conjugate plant extracts or phytoconstituents with phospholipids 8 . This conjugation results in the formation of a complex with improved solubility, stability, and bioavailability 9 . Several studies have reported the potential of phytosomes in cancer therapy 10 .…”

Section: Introductionmentioning

confidence: 99%

Phytosomes: A Promising Nanocarrier for Enhanced Delivery of Herbal Compounds in Cancer Therapy

Saeed,

Sadr,

Gharib

et al. 2022

J Lab Anim. Res

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Cancer is a life-threatening disease that remains a global health problem, with millions of people diagnosed yearly. Despite significant progress in cancer treatment, conventional chemotherapy still faces several limitations, including poor solubility, low bioavailability, lack of selectivity, and severe side effects. Therefore, alternative therapeutic strategies are necessary to improve cancer therapy. This review aimed to provide an updated overview of phytosome complexes and their potential application in cancer therapy, including their formulation techniques, transportation mechanism through phytosome, and recent investigations on their efficacy in treating different types of cancers. In recent years, nanotechnology has emerged as a promising approach to cancer therapy, as it enables the delivery of therapeutic agents to the tumor site with higher selectivity and efficiency. Phytosomes are a nanotechnology-based drug delivery system conjugating plant extracts or phytoconstituents with phospholipids. This conjugation results in the formation of a complex with improved solubility, stability, and bioavailability. Phytosomes have been shown to enhance the pharmacokinetic profile of phytoactive compounds, allowing for better targeting and sustained release. Phytosomes of curcumin, resveratrol, and quercetin have demonstrated anticancer properties in various in vitro and in vivo models. Moreover, phytosomes have been used to deliver chemotherapeutic agents, such as paclitaxel, docetaxel, and camptothecin, with improved efficacy and reduced toxicity. Phytosome complexes offer a promising platform for cancer therapy due to their ability to enhance the bioavailability and efficacy of phytoactive compounds. Incorporating phytosomes in cancer therapy could lead to the development of more effective and less toxic treatments for different types of cancers. Further studies are needed to elucidate the mechanism of action of phytosomes and to optimize their formulation for clinical use.

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Phytosomes—Nanoarchitectures' Promising Clinical Applications and Therapeutics

Cited by 16 publications

References 76 publications

Formulation, Optimization, and Evaluation of Moringa oleifera Leaf Polyphenol-Loaded Phytosome Delivery System against Breast Cancer Cell Lines

Formulation, Optimization, and Evaluation of Moringa oleifera Leaf Polyphenol-Loaded Phytosome Delivery System against Breast Cancer Cell Lines

Nanophytosome formulation of β-1,3-glucan and Euglena gracilis extract for drug delivery applications

Phytosomes: A Promising Nanocarrier for Enhanced Delivery of Herbal Compounds in Cancer Therapy

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