Phytosome as a Prominent Option in Drug Delivery for the Treatment of the Diseases: A Review

Sanha, Aloisio Mateus Fiuza; Sharma, Pooja; Kumar, Sampath

doi:10.35652/igjps.2018.119123

Cited by 2 publications

(2 citation statements)

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“…Phytosome technology has revolutionized the pharmaceutical, nutraceutical and cosmetics industries, because phytosomes, compared with conventional plant formulations and other nano-delivery systems, have significant advantages: The phytochemical complexed in the phytosome is better protected from oxidation and degradation, improving its stability and increasing its long-term effects in pharmaceutical and cosmetic compositions [ 97 ]; Compared with other nano-delivery systems, phytosomes have a simpler production method [ 98 ]; The process of phytosome formation ensures efficient and meaningful drug/nutraceutical entrapment [ 99 ]; Cellular uptake of the phytoactive constituents is enhanced and consequently, the required dose is reduced [ 100 , 101 ]; Phosphatidylcholine acts both as a hepatoprotective agent, providing a synergistic effect, especially with hepatoprotective constituents found in the phytosomal complex, and as a supplement, with beneficial nutritional effects [ 102 ]; Compared with liposomes, they are much smaller, and have different hydrogen bonds; the phytochemicals present in the phytosome are not dissolved in solvents or enveloped by the liposomal membrane, but are bound through chemical bonds with the polar head of phospholipids [ 103 ]; Pharmacokinetic-type studies and pharmacodynamic tests conducted in experimental animals and human subjects have shown improved oral and percutaneous absorption of polar phytoactive compounds, increased bioavailability of the bioactive compound compared with non-complexed botanical derivatives, and enhanced therapeutic effects [ 104 ]. The main disadvantages associated with phytosomes are: The pH sensitivity of phospholipids, due to their Zeta potential values, which must be considered when preparing phytosome formulations [ 105 ]; Phytosome formation technology produces the rapid removal of phytoconstituents from the phytosome [ 106 ]. …”

Section: Phytochemicals and Phytosomesmentioning

confidence: 99%

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Inflammation, Mitochondria and Natural Compounds Together in the Circle of Trust

Nesci

Spagnoletta

Oppedisano

2023

IJMS

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Human diseases are characterized by the perpetuation of an inflammatory condition in which the levels of Reactive Oxygen Species (ROS) are quite high. Excessive ROS production leads to DNA damage, protein carbonylation and lipid peroxidation, conditions that lead to a worsening of inflammatory disorders. In particular, compromised mitochondria sustain a stressful condition in the cell, such that mitochondrial dysfunctions become pathogenic, causing human disorders related to inflammatory reactions. Indeed, the triggered inflammation loses its beneficial properties and turns harmful if dysregulation and dysfunctions are not addressed. Thus, reducing oxidative stress with ROS scavenger compounds has proven to be a successful approach to reducing inflammation. Among these, natural compounds, in particular, polyphenols, alkaloids and coenzyme Q10, thanks to their antioxidant properties, are capable of inhibiting the activation of NF-κB and the expression of target genes, including those involved in inflammation. Even more, clinical trials, and in vivo and in vitro studies have demonstrated the antioxidant and anti-inflammatory effects of phytosomes, which are capable of increasing the bioavailability and effectiveness of natural compounds, and have long been considered an effective non-pharmacological therapy. Therefore, in this review, we wanted to highlight the relationship between inflammation, altered mitochondrial oxidative activity in pathological conditions, and the beneficial effects of phytosomes. To this end, a PubMed literature search was conducted with a focus on various in vitro and in vivo studies and clinical trials from 2014 to 2022.

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Section: Phytochemicals and Phytosomesmentioning

confidence: 99%

“…Phytosome formation technology produces the rapid removal of phytoconstituents from the phytosome [ 106 ].…”

Section: Phytochemicals and Phytosomesmentioning

confidence: 99%

Inflammation, Mitochondria and Natural Compounds Together in the Circle of Trust

Nesci

Spagnoletta

Oppedisano

2023

IJMS

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Phytosome: An Effective Transdermal Drug Delivery System for Phytoconstituents

Mahmoudabad

Shirshahi

Mehrabi

et al. 2023

LDDD

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Herbal medicine and phytochemicals have always been great therapeutic options to treat various diseases due to their compatibility, safety, easy production, low cost and side effects. However, low absorption rate ,and poor bioavailability are notable challenges that have limited the use of most phytoconstituents. To address these challenges, different drug delivery methods have been proposed for generating operative carrier systems for phytochemicals. Among them, transdermal drug delivery (TDD) using nanophytosome has been introduced as a promising candidate for the delivery of insoluble phytoconstituents. Phytosomes can overcome skin barriers, and are therefore effective carriers for herbal medicines. They are generally produced by combining phytoconstituent agents in medicinal plant extracts with phospholipid molecules. They have improved the clinical applications of phytoconstituents such as polyphenols by enhancing their bioavailability and uptake. In this review, main benefits of transdermal delivery systems, advantages of nanophytosome over other lipid nanoparticles in TDD of phytochemicals, and methods of phytosome preparation and characterization are briefly reviewed.

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Phytosome as a Prominent Option in Drug Delivery for the Treatment of the Diseases: A Review

Cited by 2 publications

References 10 publications

Inflammation, Mitochondria and Natural Compounds Together in the Circle of Trust

Inflammation, Mitochondria and Natural Compounds Together in the Circle of Trust

Phytosome: An Effective Transdermal Drug Delivery System for Phytoconstituents

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