Phytopharmacological evaluation of aerial parts of Woodfordia fruticosa (L.) Kurz in Cough Variant Asthma

Abstract

Background: Cough variant asthma (CVA) is characterized by prolonged non productive cough which responds to bronchodilator therapy. None of herbal drug is reported to possess pharmacological activity against CVA. Objective: To investigate the pharmacological potential of ethanolic extract of Woodfordia fruticosa (L.) Kurz (EEWF) against CVA as well as to develop an efficient screening model for CVA. Material and Method: Anti-tussive effect of EEWF was evaluated against nebulized aqueous solution of 0.1 g/ml of citric acid to determine the cough response. EEWF potential was finally accessed against aerosolic mixture of 0.3 g/ml of citric acid mixed with 0.1% histamine and 2% acetylcholine chloride to evaluate the convulsive latency, percentage protection and cough frequency against CVA. Results: EEWF at aerosolic dose of 6% w/v exhibit decrease in of the average coughs frequency (4.83 ± 0.30) which is quite significant effect as compared to standard drug codeine. EEWF against aerosol induced CVA was found to exhibit a significant bronchoprotection of 41.75% and decreases number of coughs SUMMARY• The present study investigated a potential curative effect of ethanolic extract of Woodfordia fruticosa (L.) Kurz in Aerosol induced Cough Variant Asthma.• As none of any model exists to assess the activity of the drug for CVA, so our study also aimed to develop an effective pharmacological screening model for CVA.• The extract not only protects the animals from bron¬choconstriction and bronchospasm but also suppress the cough frequency, which almost covers the basic etiological relevance for CVA, which pharmacologically corroborates its effective treatment against CVA.

Evaluation of antitussive and anti-asthmatic activity of Tabernaemontana divaricata(L.) R. Br. Ex Roem. and Schult

“…The above protocol was performed for every animal from each group for 10 min after exposing animals to the aerosol solutions of saline (for a baseline measurement), codeine solution (0.03 g/ml, standard), TDEE (3% w/v), and TDEE (6% w/v) for at least 7 min and was observed for cough response. [ 27 28 ]…”