Phytopharmaceutical properties and quality assessment of two Himalayan medicinal plants, Meconopsis horridula and Meconopsis simplicifolia

Wangchuk, Phurpa; Samten, -; Jamtsho, Tenzin

doi:10.1016/j.hermed.2023.100628

Cited by 5 publications

(8 citation statements)

References 42 publications

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“…The HPTLC sample preparation and profile development was conducted following the methods described by Wangchuk and Jamtsho [ [37] , [38] , [39] ]. The instrumentation system (CAMAG®, Muttenz, Switzerland) consisted of a DigiStore2 digital system along with winCATS software ver.1.4.3 (CAMAG®, Muttenz, Switzerland), automatic developing chamber CAMAG ADC2, a Linomat 5 sample applicator with 100 μL syringes, and twin trough chambers (Analtech, USA).…”

Section: Methodsmentioning

confidence: 99%

“…The demand for herbal medicines is rising, driven by their perceived minimal or no side effects. However, this growing demand has also increased the risk of adulteration with incorrect or low-grade materials [ 10 ]. Thus, to ensure the safety of traditional medicines, accurately identifying their primary ingredients is the first critical step.…”

Section: Introductionmentioning

confidence: 99%

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Development of quality control parameters for two Bhutanese medicinal plants (Aster flaccidus Bunge and Aster diplostephioides (DC.) Benth. ex C.B.Clarke) using traditional and modern pharmacognostical platforms

Gempo,

Yeshi,

Jamtsho

et al. 2024

Heliyon

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Development of quality control parameters for two Bhutanese medicinal plants (Aster flaccidus Bunge and Aster diplostephioides (DC.) Benth. ex C.B.Clarke) using traditional and modern pharmacognostical platforms

Gempo,

Yeshi,

Jamtsho

et al. 2024

Heliyon

Self Cite

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“…Different cultures have invented their own ways of healing systems, and they exist mainly in two forms–scholarly traditional medical system (selected examples are Indian Ayurvedic medicine, Chinese traditional medicine, and Bhutanese Sowa Rigpa medicine) and oral/folklore medical system (selected examples are Australian aboriginal medicine, Kenyan medicine) [ 37 ]. Both medical systems contain enormous ethnopharmacological and ethnobotanical information that is resourceful for drug discovery and development [ 38 ]. Intuitively, the success rate of drug discovery using ethnopharmacological data is expected to be greater than with the random approach [ 36 ].…”

Section: Approaches and Techniques For The Biodiscovery Of Anti-infla...mentioning

confidence: 99%

“…Other examples include apigenin (isolated from Mentha australis R.Br. ), salicin (from Salix alba L.) [ 46 , 47 ], and protopine and kaempferol (from Meconopsis species of Bhutan) [ 38 ].…”

Section: Approaches and Techniques For The Biodiscovery Of Anti-infla...mentioning

confidence: 99%

Approaches, Strategies and Procedures for Identifying Anti-Inflammatory Drug Lead Molecules from Natural Products

Jamtsho,

Yeshi,

Perry

et al. 2024

Pharmaceuticals

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Natural products (NPs) have played a vital role in human survival for millennia, particularly for their medicinal properties. Many traditional medicine practices continue to utilise crude plants and animal products for treating various diseases, including inflammation. In contrast, contemporary medicine focuses more on isolating drug-lead compounds from NPs to develop new and better treatment drugs for treating inflammatory disorders such as inflammatory bowel diseases. There is an ongoing search for new drug leads as there is still no cure for many inflammatory conditions. Various approaches and technologies are used in drug discoveries from NPs. This review comprehensively focuses on anti-inflammatory small molecules and describes the key strategies in identifying, extracting, fractionating and isolating small-molecule drug leads. This review also discusses the (i) most used approaches and recently available techniques, including artificial intelligence (AI), (ii) machine learning, and computational approaches in drug discovery; (iii) provides various animal models and cell lines used in in-vitro and in-vivo assessment of the anti-inflammatory potential of NPs.

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“…Traditional Chinese Medicine (TCM) has documented the use of 18 Meconopsis species in the formulation of more than 47 distinct formulas (Wangchuk et al 2023). However, TCM prescriptions rarely rely on individual plants, and the identi cation of closely related Meconopsis species based on morphological characteristics alone poses challenges.…”

Section: Introductionmentioning

confidence: 99%

The complete chloroplast genome of Meconopsis simplicifolia and its genetic comparison to other Meconopsis species

Yang,

Li,

Zhu

et al. 2023

Preprint

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M. simplicifolia, an endangered Chinese herb, possesses medicinal properties used in the treatment of various disorders. Despite its importance, there is a lack of genomic information available for M. simplicifolia, hindering our understanding of its molecular biology. Therefore, this study aimed to assemble and compare the chloroplast (cp) genome of M. simplicifolia with other reported Meconopsis cp genomes. The assembled M. simplicifoliaplastome spanned 152,772 bp and exhibited the typical quadripartite structure comprising large (LSC, 83,824 bp) and small (SSC, 17,646 bp) single-copy regions, separated by a pair of inverted repeats (IRs, 25,651 bp). Overall, 131 genes were predicted, including 84 protein-coding genes, 37 tRNAs, and 8 rRNAs. Additionally, 33 SSRs and 27 long repeat sequences were identified. The seven Meconopsis species shared conserved genomic features in terms of gene structure and gene order. However, a comparison of the IR boundaries of the seven Meconopsis cp genomes revealed minor differences at the IR/SC boundary regions. Interestingly, M. simplicifolia exhibited the loss of the rpl2 gene in the IRb region, which could be valuable for future plant classification research. A phylogenetic analysis including M. simplicifolia and eight other Meconopsis species indicated that M. simplicifolia clustered together with M. betonicifolia. The availability of the cp genome sequence ofM. simplicifolia is of utmost importance for understanding phylogenetic and evolutionary aspects at or above the Meconopsislevel. Comparative analysis of the cp genomes of Meconopsis species will facilitate species identification and enable selective breeding studies of these medicinal plants.

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Phytopharmaceutical properties and quality assessment of two Himalayan medicinal plants, Meconopsis horridula and Meconopsis simplicifolia

Cited by 5 publications

References 42 publications

Development of quality control parameters for two Bhutanese medicinal plants (Aster flaccidus Bunge and Aster diplostephioides (DC.) Benth. ex C.B.Clarke) using traditional and modern pharmacognostical platforms

Development of quality control parameters for two Bhutanese medicinal plants (Aster flaccidus Bunge and Aster diplostephioides (DC.) Benth. ex C.B.Clarke) using traditional and modern pharmacognostical platforms

Approaches, Strategies and Procedures for Identifying Anti-Inflammatory Drug Lead Molecules from Natural Products

The complete chloroplast genome of Meconopsis simplicifolia and its genetic comparison to other Meconopsis species

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