Phytomedicines are Efficient Complementary Therapies for the Treatment of Atopic Dermatitis: A Review of Mechanistic Insight and Recent Updates

Tumpang, Mohamad Aidil; Ramli, Nor Amlizan; Hussain, Zahid

doi:10.2174/1389450118666170913162147

Cited by 6 publications

(2 citation statements)

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“…Additionally, oral utilization of XG and PP in adults demonstrated no systemic adverse events during 6 months of treatment [ 43 , 44 ]. To date, the literature revealed that phytotherapeutic treatments for AD and products of natural origin are often considered adjunctive therapies for the treatment of moderate to severe AD [ 18 , 45 ]. Clinical trials assessing the efficacy and safety of topical phytotherapy for AD treatment are limited.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and Tolerability of a Novel Topical Treatment Containing Pea Protein and Xyloglucan in the Management of Atopic Dermatitis in Children: A Prospective, Multicenter Clinical Study

Sowlati,

Morariu,

Orzan

et al. 2023

Dermatol Ther (Heidelb)

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Introduction: Atopic dermatitis (AD) is a chronic disease that occurs mainly in children. Topical corticosteroids are the main treatment for mild to moderate AD, although they can induce side effects. The efficacy and tolerability of xyloglucan and pea protein (XG-PP) was compared with hydrocortisone in pediatric patients with AD as a steroid-sparing solution. Methods: A prospective, multicenter, comparative study enrolled 42 patients (age 0.5--12 years) with mild-to-moderate AD, assigned 1:1 to XG-PP or hydrocortisone ointment. Treatments were applied twice daily for 14 consecutive days and assessed at baseline, day 8, and day 15. Efficacy endpoints were AD Severity Index (ADSI) score, Scoring Atopic Dermatitis (SCORAD) index, and Patient-Oriented Eczema Measure (POEM). Tolerability was assessed by the occurrence of adverse events (AEs). Prior Presentation: This work was presented as a Poster at the EADV Symposium-May 2021 by Gainaru et al.: Efficacy and safety of DE-AT0117 versus hydrocortisone in the treatment of atopic dermatitis in children: a prospective, multicenter, comparative clinical study.

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Section: Discussionmentioning

confidence: 99%

Efficacy and Tolerability of a Novel Topical Treatment Containing Pea Protein and Xyloglucan in the Management of Atopic Dermatitis in Children: A Prospective, Multicenter Clinical Study

Sowlati,

Morariu,

Orzan

et al. 2023

Dermatol Ther (Heidelb)

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“…Based on the European Scientific Cooperative on Phytotherapy (ESCOP), phytotherapy corresponds to the science of the medicinal use of plants and herbal products for the prevention and treatment of diseases [17]. Phytopharmaceuticals are used for an extensive range of conditions, such as hypertension [18], atopic dermatitis [19], and depression [20]. In terms of respiratory tract infections, a cross-sectional survey of 250 parents from Turkey revealed that the prevalence of non-drug therapeutic approaches used for their children with symptoms of viral URIs was 47.2%, and that the most common approach was herbal tea (prevalence of 30.5%) [21].…”

Section: Introductionmentioning

confidence: 99%

Changes in the Prescription of Antibiotics and Phytopharmaceuticals in Children Treated for Acute Upper and Lower Respiratory Tract Infections in Pediatric Practices in Germany in 2013, 2018, and 2022

Kostev,

van den Boom,

Tanislav

et al. 2023

Antibiotics

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Background: Little is known about the recent trends in antibiotic and phytopharmaceutical prescribing for acute upper (URIs) and lower respiratory tract infections (LRIs) in children and adolescents. Therefore, this study investigated changes in the prescription of antibiotics and phytopharmaceuticals in children diagnosed with acute URIs and LRIs in pediatric practices in Germany in 2013, 2018, and 2022. Methods: The present retrospective study included children aged 2–12 years diagnosed with acute URIs or LRIs in one of 180 pediatric practices in 2013, 2018, and 2022. The URIs included nasopharyngitis, sinusitis, pharyngitis, tonsillitis, laryngitis and tracheitis, and upper respiratory infections of multiple and unspecified sites, while the LRIs corresponded to bronchitis. The primary outcomes were the proportion of children being prescribed antibiotics and the proportion of those being prescribed phytopharmaceuticals. Results: A total of 120,894 children were diagnosed with acute URIs or LRIs in 2013 compared to 116,844 in 2018 and 127,821 in 2022. The prevalence of antibiotic prescription decreased for all diagnoses between 2013 and 2022. This decrease was statistically significant for both 2013–2018 and 2018–2022 for nasopharyngitis, pharyngitis, and bronchitis. Meanwhile, there was a significant increase in the use of phytopharmaceuticals for all diagnoses between 2013 and 2018. The prevalence of phytopharmaceutical prescription decreased slightly between 2018 and 2022, but this decrease was generally not statistically significant. Conclusions: The prescription of antibiotics has decreased and that of phytopharmaceuticals has increased in children diagnosed with acute URIs and LRIs in Germany over the last decade. More data are needed to corroborate these findings in other settings.

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Curcumin-based strategies in wound healing and skin tissue regeneration

Hussain

Thu

Rawas‐Qalaji

et al. 2022

Natural Polymers in Wound Healing and Repair

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Phytomedicines are Efficient Complementary Therapies for the Treatment of Atopic Dermatitis: A Review of Mechanistic Insight and Recent Updates

Abstract: In conclusion, herbal medicines hold great promise as complementary and alternative therapies for the treatment of mild-to-moderate AD when used as monotherapy and for the treatment of moderate-to-severe AD when used in conjunction with other pharmacological agents.

Cited by 6 publications

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Efficacy and Tolerability of a Novel Topical Treatment Containing Pea Protein and Xyloglucan in the Management of Atopic Dermatitis in Children: A Prospective, Multicenter Clinical Study

Efficacy and Tolerability of a Novel Topical Treatment Containing Pea Protein and Xyloglucan in the Management of Atopic Dermatitis in Children: A Prospective, Multicenter Clinical Study

Changes in the Prescription of Antibiotics and Phytopharmaceuticals in Children Treated for Acute Upper and Lower Respiratory Tract Infections in Pediatric Practices in Germany in 2013, 2018, and 2022

Curcumin-based strategies in wound healing and skin tissue regeneration

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