Phytohormones: Multifunctional nutraceuticals against metabolic syndrome and comorbid diseases

Kim, Seo Woo; Goossens, Alain; Libert, Claude; Immerseel, Filip Van; Staal, Jens; Beyaert, Rudi

doi:10.1016/j.bcp.2020.113866

Cited by 17 publications

(11 citation statements)

References 202 publications

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“…On the other hand, structurally diverse endogenous and exogenous compounds have also been identified as AHR ligands. 12) These include tryptophan derivatives such as kynurenine (KYN), 13,14) 6-formylindolo [3,2-b] carbazole (FICZ), 15,16) and indole-3-acetic acid (IAA), 17,18) and indole derivatives such as indole-3-carbinol (I3C) 19,20) and indirubin 21,22) (Fig. 1).…”

Section: Introductionmentioning

confidence: 99%

The Differential Selectivity of Aryl Hydrocarbon Receptor (AHR) Agonists towards AHR-Dependent Suppression of Mammosphere Formation and Gene Transcription in Human Breast Cancer Cells

Saito

Kanno

Yamashita

et al. 2021

Biological & Pharmaceutical Bulletin

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We had previously reported that treatment with the aryl hydrocarbon receptor (AHR) agonist β-naphthoflavone (βNF) suppressed mammosphere formation derived from cancer stem cells in human breast cancer MCF-7 cells (Cancer Lett., 317, 2012, Zhao et al.). Here, using several AHR agonists, we have investigated the association of this suppression with the classical ability to induce AHR-mediated gene transcription in the xenobiotic response element (XRE). The mammosphere formation assays were performed using wild-type and AHR-knockout MCF-7 cells in the presence of AHR agonists including 3-methylcholanthrene (3MC), benzo[a]pyrene (BaP), 7,12-dimethylbenz[a]anthracene (DMBA), 6-formylindolo[3,2-b]carbazole (FICZ), indirubin, indole-3-carbinol (I3C), indole-3-acetic acid (IAA), and kynurenine (KYN), followed by the XRE-reporter gene assays of the agonists. We showed that treatments with 3MC, BaP, and DMBA strongly suppressed mammosphere formation of the stem cells in an AHR-dependent manner, while other agonists showed weaker suppression. In reporter gene assays, the strength or duration of AHR/XRE-mediated gene transcription was found to be dependent on the agonist. Although strong transcriptional activation was observed with 3MC, FICZ, indirubin, I3C, IAA, or KYN after 6 h of treatment, only weak activation was seen with BaP or DMBA. While transcriptional activation was sustained or increased at 24 h with 3MC, BaP, or DMBA, appreciable reduction was observed with the other agonists. In conclusions, the results demonstrated that the suppressive effects of AHR agonists on mammosphere formation do not necessarily correlate with their abilities to induce AHR-mediated gene transcription. Hence, different AHR functions may be differentially induced in an agonist-dependent manner.

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Section: Introductionmentioning

confidence: 99%

The Differential Selectivity of Aryl Hydrocarbon Receptor (AHR) Agonists towards AHR-Dependent Suppression of Mammosphere Formation and Gene Transcription in Human Breast Cancer Cells

Saito

Kanno

Yamashita

et al. 2021

Biological & Pharmaceutical Bulletin

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“…This means that they are likely to be involved in various physiological processes. In addition, several phytohormones may also be produced by microbes, and such compounds produced in our intestines are likely to have physiological effects (Kim et al, 2020). Some phytohormones are anti-inflammatory compounds that inhibit several inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Phytohormones that are not endogenously produced can also have physiological effects and have anti-inflammatory effect. For example, gibberellins (GA) induce the anti-inflammatory protein A20 in filter epithelial cells that could protect against asthma (Chanclud and Lacombe, 2017;Kim et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Phytohormones

Ňorbová¹

2021

Agrobiodivers Improv Nutr health life Qual

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During evolution in plants, a sophisticated system of receptors and signaling pathways has emerged that allows for appropriate responses and responses to these signals. One of such signals is the plant hormone -phytohormone. Abscisic acid is a sesquiterpene, which has important roles in seed development and maturation, in the synthesis of proteins and compatible osmolytes, which enable plants to tolerate stresses due to environmental or biotic factors, and as a general inhibitor of growth and metabolic activities. Abscisic acid is essential for the initiation and maintenance of tuber dormancy. Its main antagonist is gibberellic acid, which affects carbohydrate metabolism, indicating the budding of tubers. Gibberellic acid is a naturally occurring plant hormone that is used as a plant growth regulator to stimulate both cell division and elongation that affects leaves and stems. Salicylic acid belongs to a group of plant phenols that play an important role in the regulation of plant growth, development, and interaction with other organisms. Salicylic acid (SA), a phytohormone, is a promising compound that can reduce the sensitivity of plants to environmental stresses through regulation of the antioxidant defense system, transpiration rates, stomatal movement, and photosynthetic rate. Phytohormones are essential regulators of plants in two physiological processes that coordinate growth, reproduction, and stress resistance. These molecules also show biological activities on human cells and animal models.

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“…Some phytohormones affect human diseases, such as diabetes, inflammatory bowel disease and cancers, which are also modulated by the gut microbiota [ 112 ]. For instance, previous findings have revealed the beneficial effects of ABA against inflammation-related diseases such as type 2 diabetes (T2D), colitis, atherosclerosis, glioma and depression [ 111 ].…”

Section: Potential Of Sls In Human Healthmentioning

confidence: 99%

“…Considering these effects, the use of phytohormones as multifunctional nutraceuticals against inflammation-associated diseases, in particular metabolic syndrome and its diverse comorbid symptoms, has been proposed [ 112 ]. Overall, the optimal formulation and dosage for phytohormone supplements are still to be established, although the ABA extract of fig fruit has recently been proposed for sugar control against T2D [ 114 ].…”

Section: Potential Of Sls In Human Healthmentioning

confidence: 99%

Strigolactones, from Plants to Human Health: Achievements and Challenges

2021

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Strigolactones (SLs) are a class of sesquiterpenoid plant hormones that play a role in the response of plants to various biotic and abiotic stresses. When released into the rhizosphere, they are perceived by both beneficial symbiotic mycorrhizal fungi and parasitic plants. Due to their multiple roles, SLs are potentially interesting agricultural targets. Indeed, the use of SLs as agrochemicals can favor sustainable agriculture via multiple mechanisms, including shaping root architecture, promoting ideal branching, stimulating nutrient assimilation, controlling parasitic weeds, mitigating drought and enhancing mycorrhization. Moreover, over the last few years, a number of studies have shed light onto the effects exerted by SLs on human cells and on their possible applications in medicine. For example, SLs have been demonstrated to play a key role in the control of pathways related to apoptosis and inflammation. The elucidation of the molecular mechanisms behind their action has inspired further investigations into their effects on human cells and their possible uses as anti-cancer and antimicrobial agents.

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Phytohormones: Multifunctional nutraceuticals against metabolic syndrome and comorbid diseases

Cited by 17 publications

References 202 publications

The Differential Selectivity of Aryl Hydrocarbon Receptor (AHR) Agonists towards AHR-Dependent Suppression of Mammosphere Formation and Gene Transcription in Human Breast Cancer Cells

The Differential Selectivity of Aryl Hydrocarbon Receptor (AHR) Agonists towards AHR-Dependent Suppression of Mammosphere Formation and Gene Transcription in Human Breast Cancer Cells

Phytohormones

Strigolactones, from Plants to Human Health: Achievements and Challenges

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