Phytohormone abscisic acid ameliorates cognitive impairments in streptozotocin-induced rat model of Alzheimer's disease through PPARβ/δ and PKA signaling

Khorasani, Ali; Abbasnejad, Mehdi; Esmaeili‐Mahani, Saeed

doi:10.1080/00207454.2019.1634067

Cited by 19 publications

(15 citation statements)

References 71 publications

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“…The fact that brain has the highest ABA content among the various tissues, as first reported by Le Page-Degivry et al [ 3 ], raises the possibility that ABA is produced and acts locally in the brain. ABA administration improves neuroinflammation and cognitive impairment and anxiety in rodents [ 45 , 46 ]. Interestingly, phaseic acid, the principal ABA metabolite in plants, is apparently endogenously produced in the brain and protects from ischemic injury by acting as a non-competitive inhibitor of glutamate receptors [ 47 ].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Abscisic Acid: A Conserved Hormone in Plants and Humans and a Promising Aid to Combat Prediabetes and the Metabolic Syndrome

et al. 2020

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Abscisic acid (ABA) is a hormone with a very long evolutionary history, dating back to the earliest living organisms, of which modern (ABA-producing) cyanobacteria are likely the descendants, well before separation of the plant and animal kingdoms, with a conserved role as a signal regulating cell responses to environmental challenges. In mammals, nanomolar ABA controls the metabolic response to glucose availability by stimulating glucose uptake in skeletal muscle and adipose tissue with an insulin-independent mechanism and increasing energy expenditure in the brown and white adipose tissues. Activation by ABA of AMP-dependent kinase (AMPK), in contrast to the insulin-induced activation of AMPK-inhibiting Akt, is responsible for stimulation of GLUT4-mediated muscle glucose uptake, and for the browning effect on white adipocytes. Intake of micrograms per Kg body weight of ABA improves glucose tolerance in both normal and in borderline subjects and chronic intake of such a dose of ABA improves blood glucose, lipids and morphometric parameters (waist circumference and body mass index) in borderline subjects for prediabetes and the metabolic syndrome. This review summarizes the most recent results obtained in vivo with microgram amounts of ABA, the role of the receptor LANCL2 in the hormone’s action and the significance of the endowment by mammals of two different hormones controlling the metabolic response to glucose availability. Finally, open issues in need of further investigation and perspectives for the clinical use of nutraceutical ABA are discussed.

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Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

Abscisic Acid: A Conserved Hormone in Plants and Humans and a Promising Aid to Combat Prediabetes and the Metabolic Syndrome

et al. 2020

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“…Previous studies have shown that ABA is produced in the brain (Le Page- Degivry et al, 1986;Qi, Zhang, et al, 2015) and plays a neuroprotective role in rats (Khorasani et al, 2019;Naderi et al, 2017;. However, ABA's potential to improve cognitive and motor performance in rats with harmalineinduced tremor has not yet been determined.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, ABA is able to improve cognitive impairments induced by Alzheimer's (Khorasani et al, 2019) and diabetes (Kooshki et al, 2020) diseases in rats. It has been indicated that ABA restores neuroinflammation, neurogenesis, and cognitive deficits in a rat model of high-fat diet (Ribes-Navarro et al, 2019;Sánchez-Sarasúa et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Phytohormone abscisic acid elicits positive effects on harmaline‐induced cognitive and motor disturbances in a rat model of essential tremor

Shabani

Naderi

2022

Brain and Behavior

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Objective Essential tremor (ET) as a neurological disorder is accompanied by cognitive and motor disturbances. Despite the high incidence of ET, the drug treatment of ET remains unsatisfactory. Recently, abscisic acid (ABA) has been reported to have positive neurophysiological effects in mammals. Here, the effects of ABA on harmaline‐induced motor and cognitive impairments were investigated in rats. Methods Male Wistar rats weighing 120–140 g were divided into control, harmaline (30 mg/kg, ip), ABA vehicle (DMSO+normal saline), and ABA (10 μg/rat, icv, 30 min before harmaline injection) groups. Exploratory, balance and motor performance, anxiety, and cognitive function were assessed using footprint, open field, wire grip, rotarod, and shuttle box tests. Results The results indicated that ABA (10 μg/rat) can improve harmaline‐induced tremor in rats. The administration of ABA significantly increased time spent on wire grip and rotarod. In addition, ABA had a promising effect against the cognitive impairments induced by harmaline. Conclusion Taken together, ABA has positive effects on locomotor and cognitive impairments induced by tremor. However, further studies are required to determine the exact mechanisms of ABA on the ET.

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“…It was proved that oleuropein could effectively alleviate learning and memory impairment in morphine-treated rats by inhibiting neuronal apoptosis and oxidative stress [44]. The MWM test was also pervasively used to evaluate cognition impairments, which exist in various AD models [45,46,47]. The experimental system mainly contains a water maze device, and an automatic image acquisition and software analysis system [48].…”

Section: Methodsmentioning

confidence: 99%

Rapid Identification of Tanshinone IIA Metabolites in an Amyloid-β1-42 Induced Alzherimer’s Disease Rat Model using UHPLC-Q-Exactive Qrbitrap Mass Spectrometry

et al. 2019

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Alzheimer’s disease (AD) is a neurodegenerative disorder that damages health and welfare of the elderly, and there has been no effective therapy for AD until now. It has been proved that tanshinone IIA (tan IIA) could alleviate pathological symptoms of AD via improving non-amyloidogenic cleavage of amyloid precursor protein, decreasing the accumulations of p-tau and amyloid-β1–42 (Aβ1–42), and so forth. However, the further biochemical mechanisms of tan IIA are not clear. The experiment was undertaken to explore metabolites of tan IIA in AD rats induced by microinjecting Aβ1-42 in the CA1 region of hippocampus. AD rats were orally administrated with tan IIA at 100 mg/kg weight, and plasma, urine, faeces, kidney, liver and brain were then collected for metabolites analysis by UHPLC-Q-Exactive Qrbitrap mass spectrometry. Consequently, a total of 37 metabolites were positively or putatively identified on the basis of mass fragmentation behavior, accurate mass measurements and retention times. As a result, methylation, hydroxylation, dehydration, decarbonylation, reduction reaction, glucuronidation, glycine linking and their composite reactions were characterized to illuminate metabolic pathways of tan IIA in vivo. Several metabolites presented differences in the distribution of tan IIA between the sham control and the AD model group. Overall, these results provided valuable references for research on metabolites of tan IIA in vivo and its probable active structure for exerting neuroprotection.

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Phytohormone abscisic acid ameliorates cognitive impairments in streptozotocin-induced rat model of Alzheimer's disease through PPARβ/δ and PKA signaling

Cited by 19 publications

References 71 publications

Abscisic Acid: A Conserved Hormone in Plants and Humans and a Promising Aid to Combat Prediabetes and the Metabolic Syndrome

Abscisic Acid: A Conserved Hormone in Plants and Humans and a Promising Aid to Combat Prediabetes and the Metabolic Syndrome

Phytohormone abscisic acid elicits positive effects on harmaline‐induced cognitive and motor disturbances in a rat model of essential tremor

Rapid Identification of Tanshinone IIA Metabolites in an Amyloid-β1-42 Induced Alzherimer’s Disease Rat Model using UHPLC-Q-Exactive Qrbitrap Mass Spectrometry

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