Phytohaemagglutinin in Refractory Anaemia

<i>In vivo</i> Effect of Phytohaemagglutinin on Mouse Haemopoietic Tissue

“…Only 3 cases of aplastic anaemia of unknown origin seemed to be at all affected by PHA administration. One of these [1] was improving be fore PHA treatment began and should be excluded. One was affected only to the extent of showing a slight reticulocytosis (no information about the bone marrow was given) [11], and only one [2] showed any sig-nificant improvement.…”

“…In many of the case reports of patients who re sponded to PHA, reticulocyte counts were not mentioned. In those in which they were, only 4 patients [1][2][3][4]8] had a reticulocyte count of over 4°/o. There appear to be few studies in vivo of the effect of PHA on the haemopoietic tissues of laboratory animals. E lves et al [5] gave weekly injections of PHA to rats for 4 weeks.…”