Phytofabricated metallic nanoparticles and their clinical applications

Baranwal, Anupriya; Mahato, Kuldeep; Srivastava, Ananya; Maurya, Pawan Kumar; Chandra, Pranjal

doi:10.1039/c6ra23411a

Cited by 94 publications

(36 citation statements)

References 127 publications

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“…In some papers, plants and/or their parts proved to be beneficial over the other biological processes like microbial or enzymatic resources by elaborating work to maintain microbial culture. Plants are green resources for the biological synthesis of nanoparticles containing reducing agents for instance citric acid, ascorbic acid, flavones, crude enzymes like dehydrogenases, reductases and extracellular electron shuttles, which plays a key role in the biological synthesis of nanoparticles (Figure 7) (Bai et al, 2009;Makarov et al, 2014;Baranwal et al, 2016).…”

Section: Biological Synthesismentioning

confidence: 99%

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A Comprehensive Review of Magnetic Nanomaterials Modern Day Theranostics

Gul

Khan

Rehman³

et al. 2019

Front. Mater.

242

134

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Substances at nanoscale, commonly known as "nanomaterials," have always grabbed the attention of researchers for hundreds of years. Among these different types of nanomaterials, magnetic nanomaterials have been the focus of considerable attention during the last two decades as evidenced by an unprecedented increase in the number of research papers focusing these materials. Iron oxide magnetic nanoparticles have occupied a vital position in imaging phenomena; as drug vehicles, controlled/sustained release phenomena and hyperthermia; atherosclerosis diagnosis; prostate cancer. In fact, these are wonderful "theranostic" agents with some under clinical trials for human use. In this review, we have attempted to highlight the advances taking place in the field of magnetic nanoparticles as theranostic agents. Extensive progress has been made in the two most important parameters, namely, control over the size and shape which decide the importance of iron oxide magnetic nanoparticles by developing suitable procedures like precipitation, co-precipitation, thermal decomposition, hydrothermal synthesis, microemulsion synthesis and plant mediated synthesis. After using a suitable synthetic route, workers encounter the most daunting task linked with the materials at nanoscale i.e., the protection against corrosion. Only properly protected iron oxide magnetic nanoparticles can be further connected to different functional systems to make building blocks for application in catalysis, biology and medicines. Finally, "theranostics" which is a combined application of imaging and drug delivery has been discussed. With all the potential uses, toxicity of the of iron oxide magnetic nanoparticles has been discussed.

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Section: Biological Synthesismentioning

confidence: 99%

“…Plant-mediated synthesis of metallic nanomaterials showing reduction as well as stabilization by secondary metabolites present in plant extracts for numerous applications in clinical research [adapted and modified fromMakarov et al (2014) andBaranwal et al (2016)]. …”

mentioning

confidence: 99%

A Comprehensive Review of Magnetic Nanomaterials Modern Day Theranostics

Gul

Khan

Rehman³

et al. 2019

Front. Mater.

242

134

View full text Add to dashboard Cite

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“…Conventional synthetic approaches include physical and chemical processes; however, biological processes are one of the newer approaches to allow synthesis of NSMs. In certain cases, especially invasive biomedical application of NSMs, biological approaches (microbe or plant extract assisted) become a method of choice over other conventional approaches because these (biological) approaches do not elicit cellular toxicity (Ahmed et al, 2016 ; Baranwal et al, 2016 ).…”

Section: Classification Of Nanostructured Materialsmentioning

confidence: 99%

Prospects of Nanostructure Materials and Their Composites as Antimicrobial Agents

et al. 2018

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Nanostructured materials (NSMs) have increasingly been used as a substitute for antibiotics and additives in various products to impart microbicidal effect. In particular, use of silver nanoparticles (AgNPs) has garnered huge researchers' attention as potent bactericidal agent due to the inherent antimicrobial property of the silver metal. Moreover, other nanomaterials (carbon nanotubes, fullerenes, graphene, chitosan, etc.) have also been studied for their antimicrobial effects in order ensure their application in widespread domains. The present review exclusively emphasizes on materials that possess antimicrobial activity in nanoscale range and describes their various modes of antimicrobial action. It also entails broad classification of NSMs along with their application in various fields. For instance, use of AgNPs in consumer products, gold nanoparticles (AuNPs) in drug delivery. Likewise, use of zinc oxide nanoparticles (ZnO-NPs) and titanium dioxide nanoparticles (TiO2-NPs) as additives in consumer merchandises and nanoscale chitosan (NCH) in medical products and wastewater treatment. Furthermore, this review briefly discusses the current scenario of antimicrobial nanostructured materials (aNSMs), limitations of current research and their future prospects. To put various perceptive insights on the recent advancements of such antimicrobials, an extended table is incorporated, which describes effect of NSMs of different dimensions on test microorganisms along with their potential widespread applications.

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“…Over the last few decades, the amalgamation of NM in interdisciplinary research diaspora has had a significant effect on possible biomedical applications, including bio‐ imaging, biosensing, and targeted drug delivery . NM are preferably suitable to be used as a carrier for drug‐delivery that may simplify the design and fabrication of a new generation theranostic biosensors with intricate capabilities to sense chemical and biological molecules . Noteworthy developments have been achieved in synthesis approaches as a result of which it is conceivable to make a range of NM with considerably manageable dimension shape, surface charge and physicochemical properties .…”

Section: Introductionmentioning

confidence: 99%

Engineered Nanomaterial Assisted Signal‐amplification Strategies for Enhancing Analytical Performance of Electrochemical Biosensors

et al. 2019

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The design and development of modern biosensors for sensitive and selective detection of various biomarkers is important in diversified arenas including healthcare, environment, and food industries etc. The requirement of more robust and reliant biosensors lead to the development of various sensing modules. The nanomaterials having specific optical, electrical, and mechanical strength can pave the way towards development of ultrafast, robust, and miniaturized modules for biosensors. It can provide not only the point‐of‐care applicability but also has tremendous commercial as well as industrial justification. In order to improve the performance of the sensor systems, various nanostructure materials have been readily studied and applied for development of novel biosensors. In the last few years, researchers are engaged on harnessing the unique atomic and molecular properties of advance‐engineered materials including carbon nanotubes, graphene nanosheets, metal nanoparticles, metal oxide nanoparticles, and their nano‐conjugates. In view of such recent developments in nanomaterial engineering, the current review has been formulated emphasizing the role of these materials in surface engineering, biomolecule conjugation, and signal amplification for development of various ultrasensitive and robust biosensors having commercial as well as industrial viability. Attention is given on the electrochemical biosensors incorporating various nanomaterials and their conjugates. Importance of nanomaterials in the analytical performance of the various biosensor has also been discussed. To put a perceptive insights on the importance of various nanomaterials, an extended table is incorporated, which includes probe design, analyte, LOD, and dynamic range of various electrochemical biosensors.

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Phytofabricated metallic nanoparticles and their clinical applications

Abstract: Metallic nanoparticles (MNPs) have seen myriad applications in various fields of science and technology.

Cited by 94 publications

References 127 publications

A Comprehensive Review of Magnetic Nanomaterials Modern Day Theranostics

A Comprehensive Review of Magnetic Nanomaterials Modern Day Theranostics

Prospects of Nanostructure Materials and Their Composites as Antimicrobial Agents

Engineered Nanomaterial Assisted Signal‐amplification Strategies for Enhancing Analytical Performance of Electrochemical Biosensors

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