Phytoestrogens as Potential Therapeutic Agents for the Treatment of Anxiety and Affective Disorders

Rodríguez‐Landa, Juan Francisco; Puga-Olguín, Abraham; Germán-Ponciano, León Jesús; Olmos-Vázquez, Oscar Jerónimo; Bernal-Morales, Blandina

doi:10.1016/b978-0-444-64056-7.00005-2

Cited by 6 publications

(6 citation statements)

References 102 publications

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“…Phytoestrogens are biologically active plant-derived compounds that are similar in chemical structure to 17β-estradiol and mimic estrogen-like properties [7]. Among the phytoestrogens, isoflavones and lignans are commonly used to relieve menopausal symptoms, as they are abundant in fruits, vegetables, legumes, and soy [8,9]. A study on soy intake in various countries revealed that the average daily soy intake is nine times higher in Asian countries compared to North American and European countries, resulting in a higher life expectancy on average [10].…”

Section: Introductionmentioning

confidence: 99%

Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases

et al. 2019

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Plant-derived compounds have recently attracted greater interest in the field of new therapeutic agent development. These compounds have been widely screened for their pharmacological effects. Polyphenols, such as soy-derived isoflavones, also called phytoestrogens, have been extensively studied due to their ability to inhibit carcinogenesis. These compounds are chemically similar to 17β-estradiol, and mimic the binding of estrogens to its receptors, exerting estrogenic effects in target organs. Genistein is an isoflavone derived from soy-rich products and accounts for about 60% of total isoflavones found in soybeans. Genistein has been reported to exhibit several biological effects, such as anti-tumor activity (inhibition of cell proliferation, regulation of the cell cycle, induction of apoptosis), improvement of glucose metabolism, impairment of angiogenesis in both hormone-related and hormone-unrelated cancer cells, reduction of peri-menopausal and postmenopausal hot flashes, and modulation of antioxidant effects. Additionally, epidemiological and clinical studies have reported health benefits of genistein in many chronic diseases, such as cardiovascular disease, diabetes, and osteoporosis, and aid in the amelioration of typical menopausal symptoms, such as anxiety and depression. Although the biological effects are promising, certain limitations, such as low bioavailability, biological estrogenic activity, and effects on target organs, have limited the clinical applications of genistein to some extent. Moreover, studies report that modification of its molecular structure may eliminate the biological estrogenic activity and its effects on target organs. In this review, we summarize the potential benefits of genistein on menopause symptoms and menopause-related diseases like cardiovascular, osteoporosis, obesity, diabetes, anxiety, depression, and breast cancer.

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Section: Introductionmentioning

confidence: 99%

Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases

et al. 2019

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“…The combination also downregulated hypoxia induced HRE complex [69] Murine macrophage cell line RAW264. 7 Macrophages treatment with genistein reduced their cell viability due to cell cycle arrest at G2/M phase. It also leads to the phosphorylation of p38 MAP kinase [70] Androgen-dependent PCa cells (LNCaP) and bone metastatic LNCaP-derivative PCa cells Genistein in combination with daidzein possess synergistic effects in inhibiting the cell proliferation and induction of apoptosis on early stage androgen dependent and bone metastatic LNCaP derivative PCa cells [71] Breast cancer cell line (T47D) Genistein showed # oxidative stress according to ERα/ERβ ratio.…”

Section: Human Breast Cancer Cells (Mcf-7)mentioning

confidence: 99%

“…[6] It has been observed from clinical trials that administrating the specific dose of phytoestrogen could protect a woman from age related diseases such as several types of cancers, anxiety, postmenuposal symptoms and affective disorders. [7] Recently, interest in phytoestrogens such as genistein (1), daidzein (2), glycitein (3), formononetin (4), biochanin A ( 5) apigenin (6) (Figure 1) has been increasing as potential anticancer agents that limit the cell proliferation in different types of cancer cells indicated by the increase in the number of scientific reports and patents published on these scaffolds all over the world. [8] Also, many of these phytoestrogens are in clinical trials (www.clinicaltrials.…”

Section: Introductionmentioning

confidence: 99%

“…Phytoestrogens has gained attention in anticancer researches because of their structural and functional similarity with 17β‐estradiol known to modulate multiple molecular targets in breast cancer cells and due to their broad spectrum of activities such as oestradiol as well as antiangiogenic, (antimetastatic), and epigenetic effects [6] . It has been observed from clinical trials that administrating the specific dose of phytoestrogen could protect a woman from age related diseases such as several types of cancers, anxiety, postmenuposal symptoms and affective disorders [7] . Recently, interest in phytoestrogens such as genistein (1), daidzein (2), glycitein (3), formononetin (4), biochanin A (5) apigenin (6) (Figure 1) has been increasing as potential anticancer agents that limit the cell proliferation in different types of cancer cells indicated by the increase in the number of scientific reports and patents published on these scaffolds all over the world [8] .…”

Section: Introductionmentioning

confidence: 99%

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Therapeutic Potential of Genistein and its Derivatives as a Target for Anticancer Agents

Gupta

Kumar³

et al. 2023

ChemistrySelect

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Genistein is a natural isoflavone and a phytoestrogen known to possess broad range of pharmacological properties specifically explored for anticancer effects. The compound is under clinical trials for different types of cancer treatment. Structural modification of genistein has been done to prepare analogs with improved anticancer potential and pharmaceutical properties. Also, novel formulations of genistein have been developed to further improve water solubility and bioavailability for better clinical effectiveness. In the present review, we have summarized the recent available literature on genistein anticancer effects along with mechanism of action and clinical trial studies, reported analogs and novel formulations developed for improving the anticancer efficacy of genistein during the period 2013–2022. Also, the structure activity relationship (SAR) study of reported genistein analogs is described. Further, articles published in this period showed that both genistein and its various derivatives exhibit promising potential for the development of effective chemotherapeutic agents against different types of cancer. Further, the present review will help the researchers in design and development of genistein formulation with desired drug profile.

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“…Phytoestrogens are nonsteroidal, plant-derived compounds that are structurally or functionally similar to mammalian estrogens ( Patisaul and Jefferson, 2010 ). Phytoestrogens are polyphenolic compounds and have antioxidant activity ( Rodríguez-Landa et al, 2018 ). Phytoestrogens selectively bind to estrogen receptors, ERα and ERβ, like estrogens and are known to be effective in treating menopausal symptoms, such as osteoporosis, hot flashes and vasomotor symptoms, and anxiety and depression symptoms ( Sirotkin and Harrath, 2014 ; Rodríguez-Landa et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Elaeagnus angustifolia L. on the Thyroid-Stimulating Hormone, Dehydroepiandrosterone-Sulfate, Prolactin and Cortisol Levels in Post-Menopausal Women: A Double-Blind, Randomized, and Placebo-Controlled Study

Jalalvand

Rezaei

Badehnoosh³

et al. 2021

Front. Pharmacol.

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Menopause is the last menstrual period associated with a decline in ovarian steroid secretion and follicular loss. Hormone profile changes during menopause include a decrease in the production of estrogen, dehydroepiandrosterone (DHEA), and prolactin (PRL), and an increase in thyroid-stimulating hormone (TSH) and cortisol. Herbal medicines are considered as alternatives to hormone therapy. The studies on postmenopausal women have shown that Elaeagnus angustifolia L. (called “Senjed” in Persian) has some efficacy in improving sex hormone and lipid profiles, joint pain, and cardiovascular function, as the decrease in luteinizing hormone, low-density lipoprotein, and heart rate was significant. The aim of the present study was to evaluate the effects of E. angustifolia on TSH, DHEA-S, PRL, and cortisol levels and their ratios in postmenopausal women. It is assumed that the eventual effects of hormones on the brain and other tissues are determined by the balance between interdependent hormones. In the present randomized double-blinded placebo-controlled trial (https://en.irct.ir/search/result?query=IRCT20170227032795N4), fifty-eight postmenopausal women were randomly assigned to one of two medicinal herb (15 g of the whole E. angustifolia fruit powder) and placebo (7.5 g isomalt + 7.5 g cornstarch) groups. After 10 weeks of the treatment, the serum levels of TSH, DHEA-S, PRL, cortisol hormones, and their ratios were measured. The increase in the TSH, and cortisol levels, and cortisol/DHEA-S ratio and the decrease in prolactin and DHEA-S and the PRL/TSH, PRL/cortisol, and DHEA-S/TSH ratios after E. angustifolia consumption were significant only based on within-group but not on the between-group analysis. Based on between-group analyses, the changes in the hormone profile were not significant in the placebo group. According to Iranian tradition and folklore, E. angustifolia fruit is a symbol of female fertility. Therefore, its consumption is highly recommended to maintain health in the elderly, especially women. However, the observed outcomes about the effect of E. angustifolia on menopause were not completely in line with the Iranian folklore. E. angustifolia consumption did not significantly affect the hormone profile and ratios at the end of the ten-week trial, possibly due to the small sample size, short time, and the fact that our participants were postmenopausal women.

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Phytoestrogens as Potential Therapeutic Agents for the Treatment of Anxiety and Affective Disorders

Cited by 6 publications

References 102 publications

Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases

Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases

Therapeutic Potential of Genistein and its Derivatives as a Target for Anticancer Agents

The Effects of Elaeagnus angustifolia L. on the Thyroid-Stimulating Hormone, Dehydroepiandrosterone-Sulfate, Prolactin and Cortisol Levels in Post-Menopausal Women: A Double-Blind, Randomized, and Placebo-Controlled Study

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