Phytoestrogens and mycoestrogens in surface waters — Their sources, occurrence, and potential contribution to estrogenic activity

Jarošová, Barbora; Javůrek, Jakub; Adamovský, Ondřej; Hilscherová, Klára

doi:10.1016/j.envint.2015.03.019

Cited by 50 publications

(12 citation statements)

References 85 publications

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“…The cEEQ values for the estrogenic mycotoxins in this study (Tab. 3) were higher than those reported in natural waters in Europe and USA (< 0.01to 0.63 ng L -1 ) 27 , except for the study performed by Kolpin et al 9 , in which the highest value of cEEQ was calculated (New York, USA) for α-ZEL (< 8.8 to 388 ng L -1 ).…”

Section: Estrogenicitymentioning

confidence: 58%

Estrogenic mycotoxins in surface waters of the Rico Stream micro-basin, São Paulo, Brazil: occurrence and potential estrogenic contribution

2020

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The aim of this study was to assess the occurrence of zearalenone (ZEN) and its metabolites zearalanone (ZAN), α-zearalenol (α-ZEL), β-zearalenol (β-ZEL) α-zearalanol (α-ZAL), and β-zearalanol (β-ZAL) in the surface waters of northern São Paulo state (Brazil) and to evaluate the associated potential estrogenic contribution to the aquatic environment. The determination of the estrogenic mycotoxins in water samples from the Rico Stream microbasin yielded levels of up to 59 ng L-1 and their corresponding calculated estrogenic equivalent (cEEQ) values were between < 0.03 and 1.4 ng L-1, which are associated with negative effects on the reproduction and growth of some fish species. The physicochemical and microbiological parameters were evaluated to determine the water quality in the Rico stream region. This study revealed the first data about the presence of estrogenic mycotoxins in the Brazilian river waters and emphasizes the need to include these substances in future public policies concerning water quality, since these compounds are not yet legally regulated. From an environmental aspect, it is necessary to take into account the continuous introduction into surface water of microcontaminants associated with wastewater effluent, such as estrogenic mycotoxins.

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Section: Estrogenicitymentioning

confidence: 58%

Estrogenic mycotoxins in surface waters of the Rico Stream micro-basin, São Paulo, Brazil: occurrence and potential estrogenic contribution

2020

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“…In addition to anthropogenic and natural estrogens of vertebrate origin, emerging natural compounds found in water are phytoestrogens and mycoestrogens. The main compounds detected in surface water from different rivers are biochanin A (0–19 μg/L), genistein (0–2.65 μg/L), and daidzein (0–43 μg/L) for phytoestrogens and zearalenone (0–80 ng/μL) for mycoestrogens (for review, see [ 100 ]). Recently, we have characterized the biological effect of these compounds on breast cancer cell proliferation.…”

Section: Edcs and Breast Cancermentioning

confidence: 99%

Emerging Estrogenic Pollutants in the Aquatic Environment and Breast Cancer

Lecomte

Habauzit

Charlier

et al. 2017

Genes

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The number and amount of man-made chemicals present in the aquatic environment has increased considerably over the past 50 years. Among these contaminants, endocrine-disrupting chemicals (EDCs) represent a significant proportion. This family of compounds interferes with normal hormonal processes through multiple molecular pathways. They represent a potential risk for human and wildlife as they are suspected to be involved in the development of diseases including, but not limited to, reprotoxicity, metabolic disorders, and cancers. More precisely, several studies have suggested that the increase of breast cancers in industrialized countries is linked to exposure to EDCs, particularly estrogen-like compounds. Estrogen receptors alpha (ERα) and beta (ERβ) are the two main transducers of estrogen action and therefore important targets for these estrogen-like endocrine disrupters. More than 70% of human breast cancers are ERα-positive and estrogen-dependent, and their development and growth are not only influenced by endogenous estrogens but also likely by environmental estrogen-like endocrine disrupters. It is, therefore, of major importance to characterize the potential estrogenic activity from contaminated surface water and identify the molecules responsible for the hormonal effects. This information will help us understand how environmental contaminants can potentially impact the development of breast cancer and allow us to fix a maximal limit to the concentration of estrogen-like compounds that should be found in the environment. The aim of this review is to provide an overview of emerging estrogen-like compounds in the environment, sum up studies demonstrating their direct or indirect interactions with ERs, and link their presence to the development of breast cancer. Finally, we emphasize the use of in vitro and in vivo methods based on the zebrafish model to identify and characterize environmental estrogens.

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“…For example, Cyanobacteria have able to produce retinoid like compounds, potentially causing significant developmental impacts in amphibians and fish (Wu et al, 2012;Smutná et al, 2017). Feminisation of fish due to oestrogenic compounds is widely recognized, with mycoestrogens and phytoestrogens as likely contributors in highly contaminated ecosystems (Jarošová et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Impacts of the mycotoxin zearalenone on growth and photosynthetic responses in laboratory populations of freshwater macrophytes (Lemna minor) and microalgae (Pseudokirchneriella subcapitata)

Eagles

Benstead

MacDonald

et al. 2019

Ecotoxicology and Environmental Safety

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Phytoestrogens and mycoestrogens in surface waters — Their sources, occurrence, and potential contribution to estrogenic activity

Cited by 50 publications

References 85 publications

Estrogenic mycotoxins in surface waters of the Rico Stream micro-basin, São Paulo, Brazil: occurrence and potential estrogenic contribution

Estrogenic mycotoxins in surface waters of the Rico Stream micro-basin, São Paulo, Brazil: occurrence and potential estrogenic contribution

Emerging Estrogenic Pollutants in the Aquatic Environment and Breast Cancer

Impacts of the mycotoxin zearalenone on growth and photosynthetic responses in laboratory populations of freshwater macrophytes (Lemna minor) and microalgae (Pseudokirchneriella subcapitata)

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