Phytoestrogens and breast cancer in postmenopausal women: a case control study

Murkies, Alice L.; Dalais, Fabien S; Briganti, Esther M.; Burger, Henry; Healy, David; Wahlqvist, Mark L.; Davis, Susan R.

doi:10.1097/00042192-200007050-00003

Cited by 76 publications

(27 citation statements)

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“…No association between cancer, including breast cancer, and total flavonoids was found in the combined analysis of the 16 cohorts of the Seven Countries Study (Hertog et al, 1995). An inverse association between urinary excretion of phytooestrogens, including isoflavones, was found among Chinese women in Shanghai (Zheng et al, 1999;Dai et al, 2002) and Australian women (Ingram et al, 1997;Murkies et al, 2000), but no such association was evident in a similar study in Netherlands (den Tonkelaar et al, 2001). With respect to isoflavones, our data do not support those reported from studies in China and Australia.…”

Section: Discussionmentioning

confidence: 98%

“…A special interest on breast cancer stems from the fact that several flavonoids, particularly isoflavones, have also antioestrogenic effects (So et al, 1997;Papas, 1999). Some (Ingram et al 1997;Zheng et al, 1999;Murkies et al, 2000;Dai et al, 2002) but not all (den Tonkelaar et al, 2001) studies have found that diets high in isoflavones are associated with decreased breast cancer risk. All these studies have relied on urinary excretion measurements, which can theoretically be affected by disease status.…”

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confidence: 99%

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Flavonoid intake and breast cancer risk: a case–control study in Greece

et al. 2003

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Flavonoids have been investigated for possible inverse associations with various chronic degenerative diseases, but there are no epidemiologic data concerning a possible association between several of the main flavonoid categories and breast cancer risk. We have applied recently published data on the flavonoid content of several foods and beverages on dietary information collected in the context of a large case -control study of 820 women with breast cancer and 1548 control women, conducted in Greece. We found a strong, statistically significant inverse association of flavone intake with breast cancer. The odds ratio for an increment equal to one standard deviation of daily flavone intake (i.e. 0.5 mg day À1 ) was 0.87, with 95% confidence interval 0.77 -0.97. The association persisted after controlling for fruit and vegetable consumption, or for other flavonoid intake. This inverse association is compatible with and may explain the reported inverse association of breast cancer with consumption of vegetables, particularly leafy vegetables. After controlling for dietary confounding, there was no association of breast cancer risk with flavanones, flavan-3-ols, flavonols, anthocyanidins or isoflavones.

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Section: Discussionmentioning

confidence: 98%

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confidence: 99%

Flavonoid intake and breast cancer risk: a case–control study in Greece

et al. 2003

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“…Previously, Dai et al (9) showed that, among 500 women in a case-control study in Shanghai, urinary excretion of isoflavonoids was significantly lower among breast cancer cases than controls. In Western populations, where exposure to low levels of isoflavones is mainly as food additives in baked products, urinary isoflavone concentrations have been shown to be inversely (11,12) or not significantly (14) associated with breast cancer risk. Of the studies which measured circulating isoflavone concentrations, one reported a positive association with breast cancer risk among women in Norwich, England (10), whereas another showed no association in premenopausal women in Germany (15), and a recent study from the Netherlands, predominantly in postmenopausal women, reported an inverse association (13).…”

Section: Discussionmentioning

confidence: 99%

“…Generally, among Asian populations, urinary or circulating isoflavone levels are associated with lower breast cancer risk (9), whereas among Western populations wherein soy food intake is typically low, associations have been positive (10), inverse (11)(12)(13), or null (14,15). The relationship between plasma isoflavone concentrations and fibrocystic breast conditions has not been evaluated.…”

Section: Introductionmentioning

confidence: 99%

Plasma Isoflavones and Fibrocystic Breast Conditions and Breast Cancer Among Women in Shanghai, China

Lampe

Nishino

Ray

et al. 2007

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Proliferative benign breast conditions are associated with elevated risk of breast cancer, whereas nonproliferative conditions are not strongly associated with risk. Factors acting before onset of hyperplasia might be associated with both benign conditions and breast cancer, whereas those on the proliferative disease-tocancer pathway would be associated only with cancer. Soy isoflavone exposure may influence breast cancer risk, but little is known of its association with benign conditions. Materials and Methods: We examined possible relationships between plasma genistein and daidzein concentrations and risk of breast disease in women, in a breast self-examination trial in Shanghai, China, diagnosed with breast cancer (n = 196) or a benign breast condition (n = 304), and 1,002 age-matched controls with no known breast disease. Benign conditions were classified as nonproliferative (n = 131) or proliferative with or without atypia (n = 173). Results: Isoflavone concentrations were inversely associated with risk of nonproliferative and prolifer-

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“…A few epidemiologic studies on isoflavone intake-mainly based on urinary excretion measurements in Asian populations with high soy consumption-have suggested an inverse association with breast cancer risk (16)(17)(18)(19)(20)(21)(22)(23). Other studies conducted in non-Asian populations with low and limited range in isoflavone intake, however, did not confirm these results (24)(25)(26)(27)(28).…”

Section: Introductionmentioning

confidence: 99%

Flavonoids and Breast Cancer Risk in Italy

Bosetti

Spertini

Parpinel

et al. 2005

Cancer Epidemiology, Biomarkers &Amp; Prevention

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111

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Few epidemiologic studies have investigated the potential relation between flavonoids and breast cancer risk. We have applied recently published data on the composition of foods and beverages in terms of six principal classes of flavonoids (i.e., flavanones, flavan-3-ols, flavonols, flavones, anthocyanidines, and isoflavones) on dietary information collected in a large-case control study of breast cancer conducted in Italy between 1991 and 1994. The study included 2,569 women with incident, histologically confirmed breast cancer, and 2,588 hospital controls. Odds ratios (OR) and 95% confidence intervals were estimated by multiple logistic regression models. After allowance for major confounding factors and energy intake, a reduced risk of breast cancer was found for increasing intake of flavones (OR, 0.81, for the highest versus the lowest quintile; P-trend, 0.02), and flavonols (OR, 0.80; P-trend, 0.06).

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Phytoestrogens and breast cancer in postmenopausal women: a case control study

Cited by 76 publications

References 0 publications

Flavonoid intake and breast cancer risk: a case–control study in Greece

Flavonoid intake and breast cancer risk: a case–control study in Greece

Plasma Isoflavones and Fibrocystic Breast Conditions and Breast Cancer Among Women in Shanghai, China

Flavonoids and Breast Cancer Risk in Italy

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