Phytoestrogenic effect of Inula racemosa Hook f – A cardioprotective root drug in traditional medicine

Kalachaveedu, Mangathayaru; Raghavan, Divya; Telapolu, Srivani; Kuruvilla, Sarah; Balakrishna, K.

doi:10.1016/j.jep.2017.09.001

Cited by 22 publications

(13 citation statements)

References 22 publications

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“…Ir extracts were analyzed using gas chromatography-mass spectrometry (GC/MS, Thermo Fisher Scientific Korea Ltd. Seoul 06177, Korea). Compound identification was based on the retention time values and reported literature for authentic compounds (Kalachaveedu et al 2017 ).…”

Section: Methodsmentioning

confidence: 99%

In vivo therapeutic potential of Inula racemosa in hepatic ischemia–reperfusion injury following orthotopic liver transplantation in male albino rats

et al. 2017

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Hepatic ischemia–reperfusion (I/R) injury mainly occurs following hepatic resection and liver transplantation and cause severe liver damage, organ injuries, and dysfunction. Pro-inflammatory cytokines that promote injury are released when kupffer cell activates after getting induced by I/R. Repercussions of oxidative stress and cardiac function against isoproterenol based myocardial infarction are caused by flavonol glycosides which are found in high concentrations in Inula racemosa (Ir).The root was deemed to have analgesic and anti-inflammatory effects, and no report has been published about the liver-protective activity against hepatic I/R. Therefore, the present study was aimed to understand the therapeutic impact of Ir in hepatic I/R injury. Male albino, Wistar strain rats were used and were grouped into four total phenolic content, free radical scavenging activity and serum enzymes were determined. Histopathological and immunohistochemical analysis were also carried out. Inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interleukin (IL-6) and protein expression of p53, bax, and bcl-2 were determined. The administration of extracts of Ir significantly increased total phenolic and free radical scavenging activity. Altered cellular morphology, cytokines and aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) were returned to near normal level. IL-6 and TNF-α levels were reduced more than 25% following treatment. Also, the protein expression of p53, bax, and bcl-2 were also returned to near normal level. Taking all these data together, it is suggested that the extracts of Ir may be a potential therapeutic agent for providing several beneficial effects in hepatic I/R injury.

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Section: Methodsmentioning

confidence: 99%

In vivo therapeutic potential of Inula racemosa in hepatic ischemia–reperfusion injury following orthotopic liver transplantation in male albino rats

et al. 2017

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“…, [ 41 ] Pushkarmoola ( Inula racemosa HOOK. F.) , [ 42 ] Vasa ( Adhatoda vasica NEES) , [ 43 ] Gokshuru ( Tribulus terrestris L) , [ 44 ] Arjuna ( Terminalia Arjuna (ROXB.) WIGHT & ARN.)…”

Section: Treatment Approach Of Rajayakshma For Covmentioning

confidence: 99%

“…, Useful in asthama, bronchitis,vomitting, diarrhea and blood disorders and having antimicrobial, anti-inflammatory and anti-oxidant activities [ 41 ] 14 Pushkarmool ( Inula racemosa HOOK. F.) Cardioprotective in nature [ 42 ] 15 Vasa ( Adhatoda vasica NEES) Widely used in respiratory disorders and having antimicrobial and antioxidant properties [ 43 ] 16 Gokshuru ( Tribulus terrestris L) Has cardio protective, anti-diabetic, antioxidant, antitumor and antiurolithic properties [ 44 ] 17 Arjuna ( Terminalia Arjuna (ROXB.) WIGHT & ARN.)…”

Section: Treatment Approach Of Rajayakshma For Covmentioning

confidence: 99%

Principles of Rajayakshma management for COVID-19

Singh¹,

Rajoria²,

Sharma³

2022

Journal of Ayurveda and Integrative Medicine

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The pandemic spread of corona virus disease 2019 (COVID-19) has become a global threat. No cure is available for this condition till date. Ayurveda, may come to rescue in these times of COVID-19 spread. In this review we have analyzed that the COVID-19 has analogy with the Rajayakshma (∼a wasting disease indicating suboptimum immune response) and the established treatment of Rajayakshma disease can be proposed for preventive as well as curative purpose.

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“…The sesquiterpene lactones present in the phytocomplex are responsible for the expectorant properties of this plant [18]. Traditionally, extracts of the plant have been used to treat bronchial/tracheal catarrh and dry irritating cough in children [19]. The extract used in the syrup is an Inula helenium roots aqueous extract, containing no less than 30% polysaccharides.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of the syrup “KalobaTUSS®” as a treatment for cough in children: a randomized, double blind, placebo-controlled clinical trial

Carnevali¹,

Paglia²,

Pauletto³

et al. 2021

BMC Pediatr

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Background Acute cough in children often causes discomfort to children and parents, reducing their quality of life. Despite the extensive utilization of over-the-counter remedies for cough, the efficacy of most of these treatments in children has not been confirmed. Methods We conducted a randomized, double blind, placebo-controlled clinical trial of 106 children with acute cough to evaluate the efficacy and safety of KalobaTUSS®, a paediatric cough syrup based on acacia honey and on Malva sylvestris extract, Inula helenium extract, Plantago major extract, and Helichrysum stoechas extract by using a validated 6 points Likert scale. Results Children were orally treated with KalobaTUSS® or placebo for 8 days. Children receiving KalobaTUSS® showed an early and significant reduction in night-time and day-time cough scores measured using a specific scale and a shorter duration of cough than children treated with the placebo. Conclusions KalobaTUSS® is well tolerated and produces positive effects by reducing the severity and shortening the duration of cough in children. Trial registration Clinicaltrials.gov no. NCT04073251. Retrospectively registered.

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Phytoestrogenic effect of Inula racemosa Hook f – A cardioprotective root drug in traditional medicine

Cited by 22 publications

References 22 publications

In vivo therapeutic potential of Inula racemosa in hepatic ischemia–reperfusion injury following orthotopic liver transplantation in male albino rats

In vivo therapeutic potential of Inula racemosa in hepatic ischemia–reperfusion injury following orthotopic liver transplantation in male albino rats

Principles of Rajayakshma management for COVID-19

Efficacy and safety of the syrup “KalobaTUSS®” as a treatment for cough in children: a randomized, double blind, placebo-controlled clinical trial

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