Phytoestrogenic effect of fenugreek seed extract helps in ameliorating the leg pain and vasomotor symptoms in postmenopausal women: A randomized, double-blinded, placebo-controlled study

Safety and influence of a novel extract of fenugreek on healthy young women: a randomized, double-blinded, placebo-controlled study

“…The observation that the supplementation of FHE increased the estrogen and testosterone levels and significantly improved the quality of sexual functions and quality of life among participants who had issues at the baseline levels indicates the beneficial effect of FHE [31]. Earlier studies have also reported significant enhancement in both estradiol and testosterones among menopausal and healthy population having low libido when supplemented with fenugreek extracts [14,[16][17][18]. Elevated concentrations of endogenous estrogen and hormonal therapy with estrogen have already been reported to ease the menopausal discomforts [32].…”

“…Fenugreek seeds have been reported to alleviate dysmenorrhea associated with menstruation [12]; supports breast size due to the mastogenic effect [13]; promotes healthy sexual life and mood with a significant impact on libido and vitality among young women [14]; helps to reduce inflammation and body pain associated with child birth [12]; helps the contraction of uterus after delivery and is a galactogogue [15]. In the case of menopausal women, it has been shown to ameliorate various menopausal discomforts related to vasomotor, urogenetic, psychological issues [16,17]. Despite all the benefits, human safety studies especially looking at the hormonal safety of fenugreek and its extracts are limited.…”

“…Recently, a hydro-ethanolic extract of fenugreek seeds (FHE; Patented and registered as FenuSMART ® ) containing protodioscin and trigonelline in a 3:1 ratio with around 10% of protodioscin was reported to alleviate both post and peri-menopausal discomforts when supplemented at 250 mg × 2/day for 42 days [16,17]. These studies also have revealed a significant hormonal change (estradiol, progesterone, and testosterone) towards attaining a normal balanced hormone levels among menopausal women [16,17]. FHE was shown to be tolerated upon supplementation at 500 mg × 2/day for 90 days on 88 postmenopausal women, without significant side effects or adverse events [18].…”

Herbal Products Used in Menopause and for Gynecological Disorders

“…However, fenugreek seed extract was less effective than hormone replacement therapy in alleviating these symptoms. A recent (2020) randomized, double-blind, placebo-controlled study on perimenopausal women taking 500 mg fenugreek extract for 42 days also showed a more than 20% reduction in hot flashes, night sweats, insomnia, and more than 30% improvement of depression [97,98]. Increases in serum 17β-estradiol, free testosterone and progesterone were observed, and decreases in follicle-stimulating hormone and steroid hormone-binding globulin.…”

“…Increases in serum 17β-estradiol, free testosterone and progesterone were observed, and decreases in follicle-stimulating hormone and steroid hormone-binding globulin. Authors speculated that this indicates the phytoestrogenic effect of fenugreek and an establishment of hormonal balance in postmenopausal women upon taking fenugreek extract [98].…”