Phytochemistry, GS-MS analysis, and heavy metals composition of aqueous and ethanol stem bark extracts of Ximenia americana

Dahiru, Mubarak Muhammad; Badgal, Enoch Buba; Musa, Neksumi

doi:10.30574/gscbps.2022.21.3.0462

Cited by 5 publications

(4 citation statements)

References 24 publications

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“…Saponins, oxalates and steroids were not detected in any of Moretologa fruit extracts. Reference [35] however noted the presence of saponins in aqueous and ethanolic extracts of X. americana stem bark and steroids were only detected in the ethanolic extract. Tannins were detected in the other three plant samples except for Morula.…”

Section: Resultsmentioning

confidence: 99%

Nutritional and Phytochemical Properties of Morula (Sclerocarya birrea), Moretologa (Ximenia americana), Mowana (Adansonia digitata L.) and Mogose (Bauhinia petersiana): Indigenous Plants in Botswana

Matenanga,

Boitumelo,

Mareko

et al. 2024

EJFOOD

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Sub-Saharan Africa continues to struggle with food insecurity, which has been made worse by issues like the COVID-19 pandemic and climate change. In the African continent, plants have been used for food and medicine for many generations. Morula (Sclerocarya birrea), Moretologa (Ximenia americana), Mowana (Adansonia digitata L.), and Mogose (Bauhinia petersiana) are among the most consumed indigenous plants in Botswana. The objective of this study was to analyse nutritional and phytochemical profiles of these indigenous plants. The results showed that protein content ranged between 1.80% (Morula) and 25.54% (Mogose). The highest fat content of 14.29% was observed in Mogose seeds. Mowana proved to be rich in calcium compared to other plants. Manganese was detected only in Mogose samples. Phytochemical screening showed the presence of various phytochemicals. Moretologa proved to be a good source of beta carotene (419.33 μg/100 g). The plants contained different amounts of ascorbic acid; 163.83, 141.59, 24.78, and 3.00 mg/100 g were recorded in Mowana, morula, Moretologa, and Mogose, respectively. Total phenols ranged between 7.98 mg/100 g (Moretologa) to 14.3 mg/100 g (Mowana). The four indigenous plants proved to have good nutritional qualities and their increased consumption may contribute positively towards efforts to attain food security in Botswana. Additionally, the plants are good sources of phytochemicals, and they may aid in the discovery of novel drugs and medicines and be useful in formulation of functional foods.

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Section: Resultsmentioning

confidence: 99%

Nutritional and Phytochemical Properties of Morula (Sclerocarya birrea), Moretologa (Ximenia americana), Mowana (Adansonia digitata L.) and Mogose (Bauhinia petersiana): Indigenous Plants in Botswana

Matenanga,

Boitumelo,

Mareko

et al. 2024

EJFOOD

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“…The ligands (compounds) used in the present study were previously reported in our study (Dahiru et al, 2022). (Sanner, 1999) and saved in PDB format.…”

Section: Ligands and Targetsmentioning

confidence: 99%

Assessment of in silico antioxidant, anti-inflammatory, and antidiabetic activites of ximenia Americana L. Olacaceae

Dahiru,

Alfa,

Abubakar

et al. 2024

Ad Med Pharma Den RE

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Persistent hyperglycemia leading to oxidative stress and inflammatory response contributes to the pathology of diabetes. This study investigated the antioxidant, antiinflammatory, and antidiabetic potential of Ximenia americana (XA) L. Olacaceae in silico exploring its possible mechanism of action. The study was carried out by molecular docking of the compounds present in XA with the antioxidant, anti-inflammatory, and antidiabetic targets followed by molecular dynamics simulation.

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“…The compounds present in the plant were detected and identified by a Gas chromatography-mass spectrometer (7890, 5975 Agilent, USA) fitted with a fused silica column (30 X0.25 mm, with 1 µm film thickness). The procedure was as we described previously (29).…”

Section: Gas Chromatography-mass Spectrometry (Gc-ms) Analysismentioning

confidence: 99%

Characterization, In Silico Antimalarial, Antiinflammatory, Antioxidant, and ADMET Assessment of Neonauclea excelsa Merr.

Musa,

Dahiru,

Badgal

2024

sciphar

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In our study, we identified the phytoconstituents and carried out antimalarial, anti-inflammatory, antioxidant, and ADMET assessments of Neonauclea excelsa. The phytochemicals were detected and quantified followed by identification via GC-MS. The antimalaria, anti-inflammatory, and antioxidant assessments were done by molecular docking (MD) and molecular dynamics simulation (MDS) while ADMET by ADMET predictions. Saponins (27.33% ±1.20) and terpenes (8.33% ±0.73) were detected while alkaloids, steroids, glycosides, and flavonoids were absent. Exactly 29 compounds were identified with squalene being the most abundant (32.41%). Compound II exhibited the lowest BA (-6.4 kcal/mol) and Ki (20.12 µM), interacting with dihydrofolate reductase-thymidylate synthase. IV exhibited the lowest respective BA and Ki interacting with Plasmodium falciparum hexose transporter protein 1 (-6.2 kcal/mol and 28.20 µM), cyclo-oxygenase-2 (-7.2 kcal/mol and 5.21 µM), and myeloperoxidase (-7.4 kcal/mol and 3.71 µM). Compound VII had the lowest respective BA and Ki interacting with inducible nitric oxide synthase (-8.0 kcal/mol and 1.35 µM), xanthine oxidase (-7.2 kcal/mol and 5.21 µM), and cytochrome p450 21A2 (-7.0 kcal/mol and 7.30 µM). The MDS showed various cluster mobilities and residue fluctuations up to 5.26, 2.96, 5.10, 3.51, 5.02, 4.65, and 6.18 Å for dihydrofolate reductase-thymidylate synthase, Plasmodium falciparum hexose transporter protein 1, inducible nitric oxide synthase (INOS), cyclo-oxygenase-2 (COX2), xanthine oxidase (XO), cytochrome p450 21A2, and myeloperoxidase, respectively. Additionally, these compounds demonstrated good pharmacological properties with minimal toxicity. Conclusively, the identified compounds might be significant contributors to the antimalarial, anti-inflammatory, and antioxidant activity of N. excelsa and are good sources of novel antimalarial, anti-inflammatory, and antioxidant drugs.

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Phytochemistry, GS-MS analysis, and heavy metals composition of aqueous and ethanol stem bark extracts of Ximenia americana

Cited by 5 publications

References 24 publications

Nutritional and Phytochemical Properties of Morula (Sclerocarya birrea), Moretologa (Ximenia americana), Mowana (Adansonia digitata L.) and Mogose (Bauhinia petersiana): Indigenous Plants in Botswana

Nutritional and Phytochemical Properties of Morula (Sclerocarya birrea), Moretologa (Ximenia americana), Mowana (Adansonia digitata L.) and Mogose (Bauhinia petersiana): Indigenous Plants in Botswana

Assessment of in silico antioxidant, anti-inflammatory, and antidiabetic activites of ximenia Americana L. Olacaceae

Characterization, In Silico Antimalarial, Antiinflammatory, Antioxidant, and ADMET Assessment of Neonauclea excelsa Merr.

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