“…A significant target of BAs is the immune system. BAs have been shown to decrease the production of pro-inflammatory cytokines, including IL-1, IL-2, IL-6, IFN-γ, and TNF-α, which finally are directed to destroy tissues such as cartilage, insulin-producing cells, bronchial, intestinal and other tissues (Ammon, 2016;Iram et al, 2017).…”