Phytochemistry and Pharmacology of Berberis Species

Mokhber-Dezfuli, Najmeh; Saeidnia, Soodabeh; Gohari, Ahmad Reza; Kurepaz-Mahmoodabadi, Mahdieh

doi:10.4103/0973-7847.125517

Cited by 103 publications

(31 citation statements)

References 16 publications

(28 reference statements)

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“…Stretching of the Cu–O peak is observed at 563 cm −1 . The effective formation of CuNPs may be attributed to the phytochemical compounds (cynaroside, cosmosiin, luteolin, apigenin, centaureidin, quercetin, 3′‐methoxy luteolin, luteolin 7‐ O ‐glucoside, apigenin 7‐ O ‐glucoside, 5‐hydroxy‐3′,4′,6,7‐ tetra ‐methoxy flavone, salvigenin, galangin, and eupatilin) present in the A. biebersteinii leaf aqueous extract, which can act as reducing as well as stabilizing agents for the reduction and formation of CuNPs . The presence of a higher percentage of polyphenolic groups is responsible for the process of reduction, while the amino acids and amide linkages in proteins are responsible for the stabilization of the CuNPs …”

Section: Resultsmentioning

confidence: 99%

“…One of the plants used is Achillea biebersteinii from the Asterales order, Asteraceae family, Asteroideae subfamily, Asterodae supertribe, Anthemideae tribe, and Achillea genus. The antioxidant components of A. Biebersteinii are cynaroside, cosmosiin, luteolin, apigenin, centaureidin, quercetin, 3′‐methoxy luteolin, luteolin 7‐ O ‐glucoside, apigenin 7‐ O ‐glucoside, 5‐hydroxy03′,4′,6,7‐tetra methoxy flavone, salvigenin, galangin, and eupatilin . A. biebersteinii is used in medicine for its hematoprotective, immunoprotetive, nephroprotective, hepatoprotective, splenoprotective, gastroprotective, esterogenic, antispermatogenic, antidiabetic, antibacterial, antiviral, antiparasitic, antifungal, antiulcer, anti‐inflammatory, antispasmodic, and especially neuroprotective effects .…”

Section: Introductionmentioning

confidence: 99%

“…The antioxidant components of A. Biebersteinii are cynaroside, cosmosiin, luteolin, apigenin, centaureidin, quercetin, 3′‐methoxy luteolin, luteolin 7‐ O ‐glucoside, apigenin 7‐ O ‐glucoside, 5‐hydroxy03′,4′,6,7‐tetra methoxy flavone, salvigenin, galangin, and eupatilin . A. biebersteinii is used in medicine for its hematoprotective, immunoprotetive, nephroprotective, hepatoprotective, splenoprotective, gastroprotective, esterogenic, antispermatogenic, antidiabetic, antibacterial, antiviral, antiparasitic, antifungal, antiulcer, anti‐inflammatory, antispasmodic, and especially neuroprotective effects . It is also used in Iranian traditional medicine for increasing the physiological activity of the central nervous system …”

Section: Introductionmentioning

confidence: 99%

“…A. biebersteinii is used in medicine for its hematoprotective, immunoprotetive, nephroprotective, hepatoprotective, splenoprotective, gastroprotective, esterogenic, antispermatogenic, antidiabetic, antibacterial, antiviral, antiparasitic, antifungal, antiulcer, anti‐inflammatory, antispasmodic, and especially neuroprotective effects . It is also used in Iranian traditional medicine for increasing the physiological activity of the central nervous system …”

Section: Introductionmentioning

confidence: 99%

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Chemical characterization and therapeutic properties ofAchillea biebersteiniileaf aqueous extract synthesized copper nanoparticles against methamphetamine‐induced cell death in PC12: A study in the nanotechnology and neurology fields

Wang

Ahmeda

Malek

et al. 2020

Applied Organom Chemis

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Recently, scientist have used metallic nanoparticles for synthesizing many new drugs in the field of neurology. One of the metals used in the metallic nanoparticles is copper. The role of Achillea biebersteinii in increasing the physiological activities of central nervous system in Iranian traditional medicine is well known. In this study fresh leaves of A. biebersteinii were used for the biosynthesis of copper nanoparticles. We also assessed the effect of copper nanoparticles on methamphetamine‐induced cell death in the PC12 cell line. The nanoparticles were analyzed by Fourier‐transform infrared spectroscopy, energy‐dispersive X‐ray spectroscopy, transmission electron microscopy, field emission scanning electron microscopy, and ultraviolet–visible spectroscopy. A 2,2‐Diphenyl‐1‐picrylhydrazyl (DPPH) free radical scavenging experiment was carried out to assess the antioxidant properties of Cu(NO3)2, A. biebersteinii, and CuNPs. The DPPH test revealed similar antioxidant activities for A. biebersteinii, CuNPs, and butylated hydroxytoluene. In the cellular and molecular part of the present study, the Trypan blue test was performed to assess cell viability. The terminal deoxynucleotidyl transferase 2′‐Deoxyuridine, 5′‐Triphosphate (dUTP) nick end labeling test clarified the DNA fragmentation and apoptosis occurrence. The Griess reaction was used to measure nitric oxide production and caspase‐3 activity was evaluated by spectrophotometry. The obtained results were fed into SPSS‐22 software and analyzed by one‐way ANOVA, followed by Tukey's post hoc test (p ≤ 0.01). The results indicate that both doses of CuNPs had cell death‐suppressing effects on nerve cells. In particular, both doses of CuNPs significantly (p ≤ 0.01) increased cell viability and NO production, and decreased cell cytotoxicity, cell death index, and caspase‐3 activity near the normal. According to these results, it seems that CuNPs could be administrated as a neuroprotective supplement or drug for the treatment of central nervous system disorders in clinical trials.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chemical characterization and therapeutic properties ofAchillea biebersteiniileaf aqueous extract synthesized copper nanoparticles against methamphetamine‐induced cell death in PC12: A study in the nanotechnology and neurology fields

Wang

Ahmeda

Malek

et al. 2020

Applied Organom Chemis

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“…There are different kinds of alkaloids such as berbamine, berberine and berberrubine in this plant [4]. Berberine has different activities, including antioxidant, anti-inflammatory, hypoglycemic [5,6], antidiabetic, antiobesity [7] antihyperlipidemic and antihypertensive activities [4]. B. vulgaris L. has been traditionally used for the treatment of fever, hyperlipidemia, bleeding, hyperglycemia, and liver disease in Traditional Persian Medicine [8,9].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of possible antioxidant activities of barberry solid formulation, a selected formulation from Traditional Persian Medicine (TPM) via various procedures

2019

Biointerface Res Appl Chem

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The purpose of this study is to reformulate a solid traditional Ghors-e- zereshk (barberry traditional tablet) from Traditional Persian Medicine (TPM) and to assess the antioxidant effect and determining the total phenol and flavonoids contents of water and hydroalcoholic extract of mentioed formulation. The antioxidant effects of water and hydroalcoholic extracts of barberry solid formulation were measured by three methods: DPPH radical scavenging, nitric oxide free radical scavenging and Ferric Reducing Antioxidant Power Assay (FRAP) reducing method. The total phenol and flavonoid content were measured by Folin-Ciocalteu and aluminum chloride colorimetric methods. For standardization ashes’ test also used. The hydro-alcoholic extract has more phenolic compounds (31.46±.13 mg GAE∕g of dry matter) than the water extract and the water extract has more flavonoid compounds (6.38±. 25 mg Quercetin ∕g of dry matter) than the hydro-alcoholic extract. The result of DPPH radical scavenging shows that the hydro-alcoholic extract has more effect than the water extract. FRAP value indicates that the hydro-alcoholic extract has more reductive activity than the water extract. The study of NO radical scavenging represents water extract 74.61±2.95 %, hydro-alcoholic extract 61.72±1.79 % thus, water and hydro-alcoholic extracts are powerful antioxidants and have hepatoprotective effects. Other relative biological effects, for example, the protective effects through oxidative stress can also be considered.

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