Phytochemistry, and pharmacological efficacy of Cordia dichotoma G. Forst. (Lashuda): A therapeutic medicinal plant of Himachal Pradesh

Raghuvanshi, Disha; Sharma, Kiran; Verma, Rachna; Kumar, Dinesh; Kumar, Harsh; Khan, Azhar Abbas; Valko, Marián; Alomar, Suliman Yousef; Alwasel, Saleh H.; Nepovimová, Eugenie; Kuča, Kamil

doi:10.1016/j.biopha.2022.113400

Cited by 11 publications

(10 citation statements)

References 70 publications

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“…Due to the addition of CMP, the TS, fiber, and ash contents of camel milk increased considerably ( p ≤ 0.05) from 13.24, 0.00, and 0.92 in the control samples to 15.94, 1.32, and 1.09 in the samples fortified with 15% CMP (T3). The high TS, ash, and fiber contents CMP compared to camel milk ( 28 ). On contrary, due to the low protein and fat concentrations of CMP, the inclusion of CMP in fermented camel milk (FCM) in varying proportions had no influence on the protein and fat contents.…”

Section: Resultsmentioning

confidence: 99%

“…In Table 2 , as the supplementation ratio rose, the TPC and DPPH% of FCM supplemented with CMP increased considerably ( p ≤ 0.05) compared to FCM without CMP. The high TPC of CMP in comparison to that of camel milk may be the cause ( 28 , 63 ). The TPC and DPPH% of yoghurt were observed to rise when sidr fruit pulp was added to camel milk in a previous study ( 30 ).…”

Section: Resultsmentioning

confidence: 99%

“…Along with a reduction in relative weight, the high CMP content from bioactive components, including vitamins, flavonoids, phenolic acids, and minerals, may have played a role in the drop in blood fat levels in rats. These bioactive components may be responsible for enhancing the BWG and final weight of hyperlipidemic rats fed FCM augmented with 10% CMP ( 28 ). Furthermore, camel milk’s high mineral and vitamin C content may serve as an antioxidant that fights free radicals ( 34 ).…”

Section: Resultsmentioning

confidence: 99%

“…In this concern, rats were given CMP-supplemented FCM showed a significant ( p ≤ 0.05) rise in HDL levels (37.12 mg/dL). The large number of elements in CMP can interact with degrading enzymes of lipids to emulsify fat, hydrolyze it, and dissolve micelles, leading to absorption ( 28 ), which might be caused by the cause of the antihyperlipidemic effects seen in CMP. These components include minerals, vitamins, polyphenols, and flavonoids.…”

Section: Resultsmentioning

confidence: 99%

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Assessment of the physicochemical and sensory characteristics of fermented camel milk fortified with Cordia myxa and its biological effects against oxidative stress and hyperlipidemia in rats

et al. 2023

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Natural feed additives and their potential benefits in production of safe and highly nutritious food have gained the attention of many researchers the last decades. Cordia myxa is a nutrient-dense food with various health benefits. Despite this fact, very limited studied investigated the physicochemical and sensory impacts of incorporation of fermented camel milk with Cordia myxa and its biological effects. The current study aimed to assess the physical, chemical, and sensory characteristics of fermented camel milk (FCM) fortified with 5, 10, and 15% Cordia myxa pulp. The study demonstrated that fortification of camel milk efficiently enhanced protein, total solids, ash, fiber, phenolic substance, and antioxidant activity. When compared to other treatments, FCM supplemented with 10% Cordia myxa pulp had the best sensory features. In addition, FCM fortified with 10% Cordia myxa pulp was investigated as a potential inhibitor of hypercholesterolemia agents in obese rats. Thirty-two male Wistar rats were split into two main groups including normal pellet group (n = 8) served as negative control group (G1) and a group of hyperlipidemic animals (n = 24) were feed on a high-fat diet (HFD). Hyperlipidemic rats group (n = 24) were then divided into three subgroups (8 per each); second group or positive control (G2) which include hyperlipidemic rats received distilled water (1 mL/day), the third group (G3) involved hyperlipidemic rats feed on FCM (10 g/day) and the fourth group (G4) included hyperlipidemic animals feed on 10 g/day FCM fortified with 10% of Cordia myxa pulp by oral treatment via an intestinal tube for another 4 weeks. In contrast to the positive control group, G4 treated with Cordia myxa showed a substantial decrease in malondialdehyde, LDL, cholesterol, triglycerides, AST, ALT, creatinine, and urea levels, while a significant increase in HDL, albumin, and total protein concentrations. The number of large adipocytes decreased while the number of small adipocytes increased after consumption of fortified FCM. The results indicated that fermented milk fortified with Cordia myxa pulp improved the functions of the liver and kidney in hyperlipidemic rats. These results demonstrated the protective effects of camel milk and Cordia myxa pulp against hyperlipidemia in rats.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Assessment of the physicochemical and sensory characteristics of fermented camel milk fortified with Cordia myxa and its biological effects against oxidative stress and hyperlipidemia in rats

et al. 2023

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“…Quercetin of Cordia dichotoma G. Forst. (Lashusa) is the most notable phytoconstituent responsible for the therapeutic efficacy [ 75 ]. Vanillic acid, nepetin, verbascoside, and hispidulin, of Clerodendrum petasites S. Moore (CP) were chosen as potential phenolic active compounds in Thai traditional medicine for the treatment of different kinds of skin diseases [ 76 , 77 , 78 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

2023

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Phenolic compounds and flavonoids are potential substitutes for bioactive agents in pharmaceutical and medicinal sections to promote human health and prevent and cure different diseases. The most common flavonoids found in nature are anthocyanins, flavones, flavanones, flavonols, flavanonols, isoflavones, and other sub-classes. The impacts of plant flavonoids and other phenolics on human health promoting and diseases curing and preventing are antioxidant effects, antibacterial impacts, cardioprotective effects, anticancer impacts, immune system promoting, anti-inflammatory effects, and skin protective effects from UV radiation. This work aims to provide an overview of phenolic compounds and flavonoids as potential and important sources of pharmaceutical and medical application according to recently published studies, as well as some interesting directions for future research. The keyword searches for flavonoids, phenolics, isoflavones, tannins, coumarins, lignans, quinones, xanthones, curcuminoids, stilbenes, cucurmin, phenylethanoids, and secoiridoids medicinal plant were performed by using Web of Science, Scopus, Google scholar, and PubMed. Phenolic acids contain a carboxylic acid group in addition to the basic phenolic structure and are mainly divided into hydroxybenzoic and hydroxycinnamic acids. Hydroxybenzoic acids are based on a C6-C1 skeleton and are often found bound to small organic acids, glycosyl moieties, or cell structural components. Common hydroxybenzoic acids include gallic, syringic, protocatechuic, p-hydroxybenzoic, vanillic, gentistic, and salicylic acids. Hydroxycinnamic acids are based on a C6-C3 skeleton and are also often bound to other molecules such as quinic acid and glucose. The main hydroxycinnamic acids are caffeic, p-coumaric, ferulic, and sinapic acids.

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Comprehensive analysis of micro and macro-minerals, phytochemicals and proximate composition of Cordia dichotoma G. forst fruits

Singh,

Nagpoore,

Singh

et al. 2024

J Food Sci Technol

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Phytochemistry, and pharmacological efficacy of Cordia dichotoma G. Forst. (Lashuda): A therapeutic medicinal plant of Himachal Pradesh

Cited by 11 publications

References 70 publications

Assessment of the physicochemical and sensory characteristics of fermented camel milk fortified with Cordia myxa and its biological effects against oxidative stress and hyperlipidemia in rats

Assessment of the physicochemical and sensory characteristics of fermented camel milk fortified with Cordia myxa and its biological effects against oxidative stress and hyperlipidemia in rats

Therapeutic Potential of Phenolic Compounds in Medicinal Plants—Natural Health Products for Human Health

Comprehensive analysis of micro and macro-minerals, phytochemicals and proximate composition of Cordia dichotoma G. forst fruits

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