Phytochemistry and Pharmacological Activities of Dracaena cinnabari Resin

Al-Awthan, Yahya S.; Bahattab, Omar

doi:10.1155/2021/8561696

Cited by 12 publications

(4 citation statements)

References 46 publications

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“…It has been used in traditional medicine systems worldwide for over 1000 years, including Arabic medicine, African medicine, and traditional Chinese medicine [5]. The resin is known for its medicinal properties, such as wound healing, pain relief, and anti-inflammatory effects [6].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Dragon Blood Resins and Their Potential as Modifying Agents for Hydrophobic Membranes

Ambarita,

Mulyati,

Arahman

et al. 2024

IJDNE

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Hydrophobic membranes often have fouling problems; thus, surface modification is required to increase membrane hydrophilicity. This can be achieved by the addition of materials containing hydrophilic groups, such as dragon blood resin (DBR). This study aims to identify the properties of DBR that are critical for the modification of hydrophobic membranes. The DBR used is a grade A resin from the species Daemonorops draco Blume. DBR was characterized by analyzing its functionalities, morphology, elemental composition, surface charge and antimicrobial activity. The results show the presence of hydroxyl groups, including O-H, C-O and C=O functions, along with the elemental composition of oxygen, nitrogen and silica, as well as a negative charge (-44.42 mV). These are expected to contribute positively to the improved hydrophilicity of the membrane. However, DBR does not exhibit antibacterial activity against E. coli, therefore the addition of DBR is limited to enhance antifouling properties of membranes. The results are useful as a primary knowledge for the modification of hydrophobic membranes based on biomaterial.

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Section: Introductionmentioning

confidence: 99%

Characterization of Dragon Blood Resins and Their Potential as Modifying Agents for Hydrophobic Membranes

Ambarita,

Mulyati,

Arahman

et al. 2024

IJDNE

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“…f. (dragon's blood tree, Asparagaceae) is one of the island's most interesting endemic trees. For centuries, people have utilized the tree's resin to treat anything from diarrhea and dysentery to ulcers [14,15]. Previous studies on the resin of D. cinnabari have shown interesting pharmacological activities including hemostasis, muscle relaxation, antidiabetic, anti-inflammatory, analgesic, antimicrobial, and anticancer effects [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Two Chalcone Derivatives with Anti-Hepatitis B Virus Activity from the Endemic Socotraen Dracaena cinnabari (Dragon’s Blood Tree)

et al. 2022

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Hepatitis B virus (HBV) infection is prevalent and continues to be a global health concern. In this study, we determined the anti-hepatitis B virus (HBV) potential of the Socotra-endemic medicinal plant Dracaena cinnabari and isolated and characterized the responsible constituents. A bioassay-guided fractionation using different chromatographic techniques of the methanolic extract of D. cinnabari led to the isolation of two chalcone derivatives. Using a variety of spectroscopic techniques, including 1H-, 13C-, and 2D-NMR, these derivatives were identified as 2,4’-dihydroxy-4-methoxydihydrochalcone (compound 1) and 2,4’-dihydroxy-4-methoxyhydrochalcone (compound 2). Both compounds were isolated for the first time from the red resin (dragon’s blood) of D. cinnabari. The compounds were first evaluated for cytotoxicity on HepG2.2.15 cells and 50% cytotoxicity concentration (CC50) values were determined. They were then evaluated for anti-HBV activity against HepG2.2.15 cells by assessing the suppression of HBsAg and HBeAg production in the culture supernatants and their half maximum inhibitory concentration (IC50) and therapeutic index (TI) values were determined. Compounds 1 and 2 indicated inhibition of HBsAg production in a dose- and time-dependent manner with IC50 values of 20.56 and 6.36 μg/mL, respectively.

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“…The resin is named dragon blood and is a traditional medicine worldwide [ 11 ]. Dragon’s blood is traditionally applied to cure wounds, relieve pain, prevent bleeding, and deal with various diseases such as diarrhea, dysentery, and ulcers [ 12 , 13 , 14 ]. The Longxue Tongluo capsule that is made of dragon’s blood is clinically used to treat cardiovascular and cerebrovascular diseases [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomics and Metabolomics Analyses Reveal Defensive Responses and Flavonoid Biosynthesis of Dracaena cochinchinensis (Lour.) S. C. Chen under Wound Stress in Natural Conditions

et al. 2022

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Dracaena cochinchinensis has special defensive reactions against wound stress. Under wound stress, D. cochinchinensis generates a resin that is an important medicine known as dragon’s blood. However, the molecular mechanism underlying the defensive reactions is unclear. Metabolomics and transcriptomics analyses were performed on stems of D. cochinchinensis at different timepoints from the short term to the long term after wounding. According to the 378 identified compounds, wound-induced secondary metabolic processes exhibited three-phase characteristics: short term (0–5 days), middle term (10 days–3 months), and long term (6–17 months). The wound-induced transcriptome profile exhibited characteristics of four stages: within 24 h, 1–5 days, 10–30 days, and long term. The metabolic regulation in response to wound stress mainly involved the TCA cycle, glycolysis, starch and sucrose metabolism, phenylalanine biosynthesis, and flavonoid biosynthesis, along with some signal transduction pathways, which were all well connected. Flavonoid biosynthesis and modification were the main reactions against wound stress, mainly comprising 109 flavonoid metabolites and 93 wound-induced genes. A group of 21 genes encoding CHS, CHI, DFR, PPO, OMT, LAR, GST, and MYBs were closely related to loureirin B and loureirin C. Wound-induced responses at the metabolome and transcriptome level exhibited phase characteristics. Complex responses containing primary metabolism and flavonoid biosynthesis are involved in the defense mechanism against wound stress in natural conditions, and flavonoid biosynthesis and modification are the main strategies of D. cochinchinensis in the long-term responses to wound stress.

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Phytochemistry and Pharmacological Activities of Dracaena cinnabari Resin

Cited by 12 publications

References 46 publications

Characterization of Dragon Blood Resins and Their Potential as Modifying Agents for Hydrophobic Membranes

Characterization of Dragon Blood Resins and Their Potential as Modifying Agents for Hydrophobic Membranes

Isolation and Characterization of Two Chalcone Derivatives with Anti-Hepatitis B Virus Activity from the Endemic Socotraen Dracaena cinnabari (Dragon’s Blood Tree)

Transcriptomics and Metabolomics Analyses Reveal Defensive Responses and Flavonoid Biosynthesis of Dracaena cochinchinensis (Lour.) S. C. Chen under Wound Stress in Natural Conditions

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