Phytochemistry and neuroprotective effects of Eclipta alba (L.) Hassk

Abstract

<jats:title>Abstract</jats:title><jats:p><jats:italic>Eclipta alba</jats:italic> (L.) Hassk. or <jats:italic>Eclipta prostrata</jats:italic> (Linn.) or <jats:italic>Eclipta erecta</jats:italic> (Linn.) is an herbaceous plant well known in Asian as African traditional medicines. These extracts are used in traditional medicine for treatment of microbial diseases and certain metabolic disorders. This review aimed to investigate phytochemical profile and neuroprotective effects of <jats:italic>E. alba</jats:italic> (L.) Hassk. Several compounds belonging to the families of phenolics, alkaloids, terpenoids and polysaccharides have been isolated, identified or characterized from <jats:italic>E. alba</jats:italic> extracts. This plant has a diverse neuropharmacological profile. Thus, its extract improves cognitive deficits and also attenuated epileptic seizures. Phytomolecules implicated in these potentials are Eclalbasaponin II and luteolin, respectively. This document updates isolated and identified organic compounds from the extracts of <jats:italic>E. alba</jats:italic> and reviews their neuropharmacological activities.</jats:p>

A Review of Traditional Uses, Phytochemistry and Pharmacological Properties of Some Vietnamese Wound-Healing Medicinal Plants

“…Several interested phenolic compounds have also been isolated from this plant, such as luteolin-7-O-β-D-glucoside, 3,4-dihydroxybenzoic acid ethyl ester, luteolin sulfate, apigenin sulfate, luteolin, wedelolactone, 7-O-methylorobol-4 ′ -O-β-D-glucoside, apigenin, and 3 ′ -hydroxybiochanin A. 44,45 Further research led to the isolation and structural elucidation of a new isoflavonoid glycoside, 7-O-methylorobol-4 ′ -O-β-D-glucopyranoside, together with seven known compounds, 3 ′ -hydroxybiochanin A, echinocystic acid 28-O-β-Dglucopyranoside, ecliptasaponin A, eclalbasaponin I, eclalbasaponin IV, echinocystic acid, and 3-oxo-16α-hydroxy-olean12-en-28-oic acid. For the first time, echinocystic acid-28-O-β-D-glucopyranoside was obtained from this genus.…”

“…Several interested phenolic compounds have also been isolated from this plant, such as luteolin-7- O -β-D-glucoside, 3,4-dihydroxy-benzoic acid ethyl ester, luteolin sulfate, apigenin sulfate, luteolin, wedelolactone, 7- O -methylorobol-4′- O -β-D-glucoside, apigenin, and 3′-hydroxybiochanin A. 44,45…”

"Eclipta alba (L.) Hassk., A Promising Medicinal Herb for Holistic Health: An overview "

“…The methanolic extract of E. alba improves cognitive deficits and attenuated epileptic seizures as well. Luteolin and eclalbasaponin II, flavonoid and steroid of E. alba respectively, are being used to prevent attenuated epileptic seizures, and have neuroprotective properties (Tambe et al Guenne et al 2020). Its hydroethanolic extract significantly exhibits antioxidant power (Mansoorali et al 2012) so has the ability to protect against cerebral ischemia (reperfusion injury that causes neural loss).…”

Alzheimer’s Disease and Herbal Combination Therapy: A Comprehensive Review

“…It is an herbaceous plant that belongs to family Asteraceae and is very well-known component of the African traditional medicinal practices reported in Asia, used to treat several metabolic and microbial disorders. In Asian countries, E. alba is used for its neuro- and hepato-protection potential(s), apart from its abilities to resolve gastrointestinal issues, hair fall, and snake-venom poisoning [ 59 ]. The plant exerts several properties such as antioxidant, relaxant, anti-hypertensive, anti-acetylcholinesterase, lipid-lowering, and anti-leptospiral activities [ 58 ].…”