Phytochemicals in the Prevention and Cure of Cancers

Wagh, Nilesh Shirish; Pai, Sandeep R.; Sonkamble, Varsha Vasantrao

doi:10.1007/978-981-15-2361-8_16

Cited by 5 publications

(2 citation statements)

References 84 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Plants are an excellent source for biologically active molecules which can be further used as a structural template for obtaining the modified derivatives with increased activity with minimum toxicity. It is essential to determine the active compound and its mechanism of action in order to process it further for determining their role as therapeutic agents (Wagh et al 2020). It also requires specific evaluation in terms of the safety as they may possess toxic elements, pesticides etc.…”

Section: Introductionmentioning

confidence: 99%

“…They selectively inhibit the proliferation and induce cell death through various pathways (Nguyen et al 2020). Compounds like curcumin, paclitaxel, resveratrol, quercetin, vincristine, ingenol mebutate have been put to use against cancer and have shown success in clinical trials and therapeutic applications (Seca and Pinto 2018;Wagh et al 2020). Plant derived compounds have long been used in the treatment of cancer and it is well documented in literature (Table 1).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anticancer Compounds from Selected Medicinal Plants: An Update

2022

Medicinal Plants: Ethnomedicine, Pharmacognosy and Therapeutic Values

View full text Add to dashboard Cite

Globally cancer is one of the leading causes of mortality. Although, rapid progression and advancement in treatment have been made to combat this life-threatening disease. Conventional therapies like chemotherapy and radiation therapy have several adverse side effects on healthy cells, therefore, a novel alternative and effective treatment regime is required to treat cancer. Currently, the benefits of using medicinal plant-derived products over synthetic medicine have significantly increased in the field of healthcare. Several medicinal plants and their bioactive compounds have shown to possess potent anti-cancer properties in vitro and in vivo. Additionally, they are less toxic, very effective and, safe when administered in cancer patients. Some of the well-established anti-tumor compounds include vinblastine, curcumin, vincristine, podophyllotoxin, taxol, orientin, camptothecin vinflunine ditartrate, anhydrovinblastine, poliglumex, combretastatins, and triptolide. Many of them are in clinical trial, only a few have been clinically approved. This chapter

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anticancer Compounds from Selected Medicinal Plants: An Update

2022

Medicinal Plants: Ethnomedicine, Pharmacognosy and Therapeutic Values

View full text Add to dashboard Cite

show abstract

Hypericum alpestre extract exhibits in vitro and in vivo anticancer properties by regulating the cellular antioxidant system and metabolic pathway of L‐arginine

Ginovyan,

Javrushyan,

Karapetyan

et al. 2024

Cell Biochemistry & Function

View full text Add to dashboard Cite

Conventional treatment methods are not effective enough to fight the rapid increase in cancer cases. The interest is increasing in the investigation of herbal sources for the development of new anticancer therapeutics. This study aims to investigate the antitumor capacity of Hypericum alpestre (H. alpestre) extract in vitro and in vivo, either alone or in combination with the inhibitors of the l‐arginine/polyamine/nitric oxide (NO) pathway, and to characterize its active phytochemicals using advanced chromatographic techniques. Our previous reports suggest beneficial effects of the arginase inhibitor NG‐hydroxy‐nor‐ l‐arginine and NO inhibitor NG‐nitro‐Larginine methyl ester in the treatment of breast cancer via downregulation of polyamine and NO synthesis. Here, the antitumor properties of H. alpestre and its combinations were explored in vivo, in a rat model of mammary gland carcinogenesis induced by subcutaneous injection of 7,12‐dimethylbenz[a]anthracene. The study revealed strong antiradical activity of H. alpestre aerial part extract in chemical (DPPH/ABTS) tests. In the in vitro antioxidant activity test, the H. alpestre extract demonstrated pro‐oxidant characteristics in human colorectal (HT29) cells, which were contingent upon the hemostatic condition of the cells. The H. alpestre extract expressed a cytotoxic effect on HT29 and breast cancer (MCF‐7) cells measured by the MTT test. According to comet assay results, H. alpestre extract did not exhibit genotoxic activity nor possessed antigenotoxic properties in HT29 cells. Overall, 233 substances have been identified and annotated in H. alpestre extract using the LC‐Q‐Orbitrap HRMS system. In vivo experiments using rat breast cancer models revealed that the H. alpestre extract activated the antioxidant enzymes in the liver, brain, and tumors. H. alpestre combined with chemotherapeutic agents attenuated cancer‐like histological alterations and showed significant reductions in tumor blood vessel area. Thus, either alone or in combination with Nω‐OH‐nor‐ l‐arginine and Nω‐nitro‐ l‐arginine methyl ester, H. alpestre extract exhibits pro‐ and antioxidant, antiangiogenic, and cytotoxic effects.

show abstract