Phytochemicals in Coffee and the Bioavailability of Chlorogenic Acids

Stalmach, Angélique; Clifford, Michael N.; Williamson, Gary; Crozier, Alan

doi:10.1002/9781444347098.ch5

Cited by 8 publications

(4 citation statements)

References 74 publications

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“…Most ANTs, especially from berries, are believed to have low bioavailability (Kay et al, 2017). The peak plasma concentration of ANTs from berries ranges between 1 and 120 nmol/L with < 1% urinary recovery confirmed by different studies (Kay, 2006) and around 0.005% level at excretion (Stalmach et al, 2012). Metabolism of ANTs occurs by the formation of sulfo-, glucurono-, or methyl-derivatives in the proximal GI tract.…”

Section: Biopharmaceutical Features Of Anthocyanins In Metabolic Syndmentioning

confidence: 61%

Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

et al. 2018

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The term “metabolic syndrome” (MetS) refers to a combination of diabetes, high blood pressure, and obesity. The origin of MetS includes a combination of multiple factors, such as sedentary lifestyle, unhealthy diet choice, and genetic factors. MetS is highly prevalent and adversely affects the general population by elevating risk of cardiovascular complications, organ failure, and much other pathology associated with late-stage diabetes. Anthocyanins (ANTs) are health-promoting bioactive compounds belonging to the flavonoids subclass of polyphenols. Numerous studies have reported the potential therapeutic benefits on MetS syndrome and diabetes from fruits rich in ANTs. This review summarizes the role of several dietary ANTs on preventing and managing MetS as well as the pharmacological mechanisms and biopharmaceutical features of their action. We also discuss potential nanoformulation and encapsulation approaches that may enhance the bioefficacy of ANTs in MetS. Experiments have demonstrated that ANTs may attenuate the symptoms of MetS via improving insulin resistance, impaired glucose tolerance, dyslipidaemia, cholesterol levels, hypertension, blood glucose, protecting β cells, and preventing free radical production. In brief, the intake of ANT-rich supplements should be considered due to their plausible ability for prevention and management of MetS. Additionally, randomized double-blind clinical trials are obligatory for evaluating the bioefficacy and pharmacological mechanisms of ANTs and their pharmaceutical formulations in patients with MetS.

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Section: Biopharmaceutical Features Of Anthocyanins In Metabolic Syndmentioning

confidence: 61%

Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

et al. 2018

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“…Although the bioavailabilities of the identified phenylindanes and vinylcatechol oligomers have not been examined to date, the abilities of caffeic acid and the related phenolic acids in coffee have been well studied. , These compounds can be absorbed in humans in their conjugated and nonconjugated forms. Ota et al examined the interaction of these phenolic acids and corresponding vinylcatechol derivatives with lipid membranes.…”

Section: Resultsmentioning

confidence: 99%

Effects of Temperature on the Composition and Xanthine Oxidase Inhibitory Activities of Caffeic Acid Roasting Products

Masuda

Fukuyama

Doi

et al. 2019

J. Agric. Food Chem.

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The high-temperature treatment of caffeic acid by a model reaction for the processing of foods by roasting enhanced its xanthine oxidase (XO) inhibitory activity. The thermal reaction products included various oligomeric compounds, whose structures were determined as being produced via the intermediate 4-vinylcatechol. Measurements of their XO inhibitory activities were also carried out. Among the identified oligomers, the coupling products of caffeic acid and vinylcatechol, which were mainly produced at 140−170°C, presented stronger XO inhibitory activities than the other types of oligomers produced. Further reacted compounds, which were mainly formed at 200°C by the addition or elimination of catechol unit in the oligomers, displayed weaker activities. These results indicated that thermal enhancement of the XO inhibitory activity of caffeic acid can be explained by the differences in the XO inhibitory activities of the various constituents of the thermal reaction products. Caffeic acid and its derivatives are polyphenols found widely distributed in foods. Moreover, XO inhibition is closely related to the prevention of the lifestyle related disease gout. The results suggest that a simple roasting process (170°C) can lend useful human-health-related functionalities to caffeic acid containing foods such as coffee.

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“…Seeds are typically well defended by plant secondary metabolites. The coffee seed is no exception, and contains high concentrations of a variety of chlorogenic acid derivatives 22 as well as its principal chemical of human interest, caffeine. The chlorogenic acid derivatives can be toxic and in many cases contain appropriate chemical structures (such as aromatics with ortho- or para-hydroxyl or methoxy groups) that can act as substrates for phenoloxidases or peroxidases, which generate reactive oxygen species and toxic quinones 23 24 .…”

Section: Resultsmentioning

confidence: 99%

Draft genome of the most devastating insect pest of coffee worldwide: the coffee berry borer, Hypothenemus hampei

Vega

Brown

Chen

et al. 2015

Sci Rep

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The coffee berry borer, Hypothenemus hampei, is the most economically important insect pest of coffee worldwide. We present an analysis of the draft genome of the coffee berry borer, the third genome for a Coleopteran species. The genome size is ca. 163 Mb with 19,222 predicted protein-coding genes. Analysis was focused on genes involved in primary digestion as well as gene families involved in detoxification of plant defense molecules and insecticides, such as carboxylesterases, cytochrome P450, gluthathione S-transferases, ATP-binding cassette transporters, and a gene that confers resistance to the insecticide dieldrin. A broad range of enzymes capable of degrading complex polysaccharides were identified. We also evaluated the pathogen defense system and found homologs to antimicrobial genes reported in the Drosophila genome. Ten cases of horizontal gene transfer were identified with evidence for expression, integration into the H. hampei genome, and phylogenetic evidence that the sequences are more closely related to bacterial rather than eukaryotic genes. The draft genome analysis broadly expands our knowledge on the biology of a devastating tropical insect pest and suggests new pest management strategies.

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Phytochemicals in Coffee and the Bioavailability of Chlorogenic Acids

Cited by 8 publications

References 74 publications

Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

Anthocyanins in the Management of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review

Effects of Temperature on the Composition and Xanthine Oxidase Inhibitory Activities of Caffeic Acid Roasting Products

Draft genome of the most devastating insect pest of coffee worldwide: the coffee berry borer, Hypothenemus hampei

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