Phytochemicals for the treatment of inflammatory bowel diseases

Schneider, Mathias; Abdel-Aziz, H; Efferth, Thomas

doi:10.1007/s11101-013-9320-6

Cited by 12 publications

(6 citation statements)

References 56 publications

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“…However, a non-controlled and inadequate activation may lead to chronic inflammation [ 33 ] with negative health implications. Nowadays, thanks to their limited side effects and anti-inflammatory properties, natural products and plant-derived compounds represent promising tools for the management and/or treatment of intestinal inflammation [ 12 , 13 ]. Moreover, many studies have well-documented the role of cereal and cereal-based fermented products in inflammatory responses [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, sourdough fermentation increases the presence of bioactive components with various functions, including antioxidant, antihypertensive, and anti-inflammatory activities [ 10 , 11 ]. Nowadays, for their limited side effects and valuable bio-functional properties, natural products and food-derived compounds represent promising tools for the management and/or treatment of hypertension and intestinal inflammation [ 12 , 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Sourdough Fermentation Improves the Antioxidant, Antihypertensive, and Anti-Inflammatory Properties of Triticum dicoccum

Gabriele

Arouna

Árvay

et al. 2023

IJMS

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The fermentation process has been widely used to improve plant-based foods’ nutritional and nutraceutical properties. This study aimed to investigate and compare the impact of sourdough fermentation on the bioactive content and profile, antioxidant and antihypertensive activities, as well as the anti-inflammatory properties of fermented (FS) and non-fermented (NFS) flour from Tuscan Triticum dicoccum wheat (spelt) on tumor necrosis factor-alpha (TNF-α)-inflamed human intestinal epithelial cells (HT-29). FS showed significantly higher total phenolic and flavonoid content, in vitro and ex vivo antioxidant activities, and ACE-inhibitory activities than NFS. Gallic acid was identified by HPLC-DAD as the most representative polyphenol, followed by rutin, trans-ferulic acid, iso-quercitrin, and quercetin, in the fermented spelt sample. Instead, rutin and gallic acid were identified as the predominant compounds in the non-fermented ones. Moreover, FS exhibited a better protective effect on inflamed HT-29 cells by significantly counteracting the TNFα-induced alterations, lowering the expression of IL-8, COX-2, and ICAM-1 inflammatory mediator while enhancing antioxidant enzyme HO-1 gene expression. In conclusion, sourdough fermentation positively affected the nutraceutical and functional properties of spelt, which may represent a valuable ingredient for the formulation of functional foods and a key product for managing hypertension and inflammatory intestinal diseases.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sourdough Fermentation Improves the Antioxidant, Antihypertensive, and Anti-Inflammatory Properties of Triticum dicoccum

Gabriele

Arouna

Árvay

et al. 2023

IJMS

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“…As the exact etiology of IBD is not well understood, there is no specific treatment available to cure the disease. Hence, flavonoids, which are known to have a range of biological activities, could be beneficial in the treatment for IBD [79,80,81]. Flavonoids such as apigenin and epigallocathechin gallate have been shown to inhibit the activation of immune cells and the downstream chemokines and cytokines [82], thereby it may considered as a natural inhibitor and can prevent the activation of an innate and adaptive immune system [79].…”

Section: Flavonoids In Health and Diseasementioning

confidence: 99%

Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin

et al. 2019

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Inflammation has been reported to be intimately linked to the development or worsening of several non-infectious diseases. A number of chronic conditions such as cancer, diabetes, cardiovascular disorders, autoimmune diseases, and neurodegenerative disorders emerge as a result of tissue injury and genomic changes induced by constant low-grade inflammation in and around the affected tissue or organ. The existing therapies for most of these chronic conditions sometimes leave more debilitating effects than the disease itself, warranting the advent of safer, less toxic, and more cost-effective therapeutic alternatives for the patients. For centuries, flavonoids and their preparations have been used to treat various human illnesses, and their continual use has persevered throughout the ages. This review focuses on the anti-inflammatory actions of flavonoids against chronic illnesses such as cancer, diabetes, cardiovascular diseases, and neuroinflammation with a special focus on apigenin, a relatively less toxic and non-mutagenic flavonoid with remarkable pharmacodynamics. Additionally, inflammation in the central nervous system (CNS) due to diseases such as multiple sclerosis (MS) gives ready access to circulating lymphocytes, monocytes/macrophages, and dendritic cells (DCs), causing edema, further inflammation, and demyelination. As the dearth of safe anti-inflammatory therapies is dire in the case of CNS-related disorders, we reviewed the neuroprotective actions of apigenin and other flavonoids. Existing epidemiological and pre-clinical studies present considerable evidence in favor of developing apigenin as a natural alternative therapy against chronic inflammatory conditions.

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“…Wells of 5 mm in diameter were prepared on inoculated agar and filled with different concentrations of extract [23]. It was then incubated at 37℃ for 24 hours and the clear zone of inhibition was measured after 24 hours [24,25].…”

Section: Antibacterial Activity Assaymentioning

confidence: 99%

Physiochemical and Antioxidant Evaluation of Moringa Oleifera Leaf Extract Followed by Phytochemical Screening and Antibacterial Activity

-¹,

-²,

-³

et al. 2023

IJFMR

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Phytomedicines are believed to have benefits over conventional drugs and are regaining interest in current research. Moringa oleifera is a multi-purpose herbal plant used as human food and an alternative for medicinal purposes worldwide. An important factor that accounts for the medicinal uses of Moringa oleifera is its very wide range of vital antioxidants, antibiotics and nutrients including vitamins and minerals. Almost all parts from Moringa can be used as a source for nutrition with other useful values. Physiochemical and antioxidant evaluation of moringa leaves yielded 6.59 % moisture content, 9.64 % total ash, 6.38 pH (1 % solution), 5.81 pH (10 % solution), 0.07 % acidity (1% solution), 0.31 % acidity (10% solution), 2.54 mg GAE/100 g total phenolic contents (TPC), 3.68 mg QE/100 g total flavonoids contents (TFC) and 71.98 DPPH radicals scavenging activity. Phytochemical screening of ethanol extracts showed the presence of coumarine, terpenoids, polyphenols, glycosides, tannins, flavonoids and alkaloids. Antibacterial assay revealed that the highest antibacterial activity of 1 mg/ml and 0.5 mg/ml of ethanolic extracts were found to be against E. coli (18.4 mm, and 9.1 mm respectively) followed by S. aureus (12.9 mm, and 8.2 mm respectively), B. subtilis (10.3 mm, and 6.5 mm respectively) and P. aeruginosa (9.3 mm, and 5.2 mm respectively). Moringa extract also inhibited the development of certain bacteria, demonstrating its anti-microbial potential. This study verifies the presence of important phytochemicals in moringa leaf extracts, leading to the conclusion that moringa leaves can be utilized to cure a variety of ailments.

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Phytochemicals for the treatment of inflammatory bowel diseases

Cited by 12 publications

References 56 publications

Sourdough Fermentation Improves the Antioxidant, Antihypertensive, and Anti-Inflammatory Properties of Triticum dicoccum

Sourdough Fermentation Improves the Antioxidant, Antihypertensive, and Anti-Inflammatory Properties of Triticum dicoccum

Potential Role of Flavonoids in Treating Chronic Inflammatory Diseases with a Special Focus on the Anti-Inflammatory Activity of Apigenin

Physiochemical and Antioxidant Evaluation of Moringa Oleifera Leaf Extract Followed by Phytochemical Screening and Antibacterial Activity

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