Phytochemicals as therapeutic interventions in neurodegenerative diseases

Isolation and Antimalarial Activity of a New Flavonol from Tithonia diversifolia Leaf Extract

“…Kavitha e al. [20] report that flavonoids play an important role in maintaining the homeostasis o the central nervous system by modulating neuronal oxidative metabolism because the are strong inhibitors of enzymes that cause neuron degeneration. There is growing evi dence that long-term ingestion of diets rich in plant polyphenols offer protection agains the development of cancers, cardiovascular diseases, diabetes, osteoporosis and neuro degenerative diseases [21].…”

“…Many flavonoids are reported to have antioxidative activity, free radical scavenging capacity, coronary heart disease prevention, hepatoprotective, anti-inflammatory, and anticancer activities, while some of them exhibit potential antiviral activities [17]. Kavitha et al [20] report that flavonoids play an important role in maintaining the homeostasis of the central nervous system by modulating neuronal oxidative metabolism because they are strong inhibitors of enzymes that cause neuron degeneration. There is growing evidence that long-term ingestion of diets rich in plant polyphenols offer protection against the development of cancers, cardiovascular diseases, diabetes, osteoporosis and neurodegenerative diseases [21].…”

Effects of Four Local Species of Beans Consumed in South-eastern Nigeria on Selected Biochemical Indices of Wistar Albino Rats

“…The result obtained for the preliminary phytochemicals screening revealed the presence of flavonoids, alkaloids, saponins, phenols, tannins, and cardiac glycosides in all the four beans aqueous extract (Table 2). The presence of these phytochemicals is an indication that these local bean species can serve as a valuable source for the discovery of novel bioactive compounds for drug discovery (Egbuna and Ifemeje, 2015;Egbuna and Ifemeje, 2017;Arul et al, 2018;Tijjani et al, 2018;Ezzat et al, 2019;Kavitha et al, 2019;Nwosu et al, 2019;Srivastav et al, 2019). The quantitative analysis revealed that P. vulgaris L 'Red kidney' had the highest flavonoids (4.44±0.11 a %), alkaloids (4.85±0.01 a %), cardiac glycosides (10.41±0.93 a %) and haemaglutinin (0.78±0.00 a mg/l) (Table 3).…”

History in Perspective: The prime pathological players and role of phytochemicals in Alzheimer’s disease

“…Moreover, it substantially diminishing the neurotoxicity, level of proinflammatory cytokines by inhibiting the neuronal MAPK pathway. Further it also decreases the excitotoxic damage caused by glutamate and has antioxidant and antiapoptotic properties ( Kavitha et al, 2020 ) Rosmarinic acid Polyphenol It decreases the hyperphosphorylation of the tau protein, prevents fibrilization in vitro and reduces β-sheet assembly in tau protein linked to AD ( Alkam et al, 2007 ) Resveratrol Polyphenol It reduces the aggregation of Aβ and its toxicity and neuroinflammation in brain, thereby substantially play a substantial neuroprotective role in the progression and treatment of moderate to mild AD. It reduces the action mechanism of free radicals and pro-inflammatory proteins by inhibiting the expression of glutathione and COX-2.…”