Phytochemicals as alternative fungicides for controlling plant diseases: A comprehensive review of their efficacy, commercial representatives, advantages, challenges for adoption, and possible solutions

Deresa, Ebisa Mirete; Diriba, Tamiru Fayisa

doi:10.1016/j.heliyon.2023.e13810

Cited by 38 publications

(20 citation statements)

References 54 publications

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“…All natural compounds that co-occur with lignans or neo-lignans, and possess C15, C16, or C17 core structures, are named nor-lignans [ 162 ]. Lignans show a large array of biological properties, including antioxidant, antifungal, antibacterial, and anti-inflammatory properties [ 163 , 164 , 165 , 166 , 167 ]. The most common biological source of lignans is flax ( Linum usitatissimum ) seeds [ 162 , 168 ].…”

Section: Natural Products From Plants Used In Medical Devicesmentioning

confidence: 99%

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Isopencu,

Covaliu-Mierlă,

Deleanu

2023

Plants

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Transdermal delivery devices and wound dressing materials are constantly improved and upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, and cost effectiveness. Therefore, researchers in the field have shown an increasing interest in using natural compounds as constituents for such systems. Plants, as an important source of so-called “natural products” with an enormous variety and structural diversity that still exceeds the capacity of present-day sciences to define or even discover them, have been part of medicine since ancient times. However, their benefits are just at the beginning of being fully exploited in modern dermal and transdermal delivery systems. Thus, plant-based primary compounds, with or without biological activity, contained in gums and mucilages, traditionally used as gelling and texturing agents in the food industry, are now being explored as valuable and cost-effective natural components in the biomedical field. Their biodegradability, biocompatibility, and non-toxicity compensate for local availability and compositional variations. Also, secondary metabolites, classified based on their chemical structure, are being intensively investigated for their wide pharmacological and toxicological effects. Their impact on medicine is highlighted in detail through the most recent reported studies. Innovative isolation and purification techniques, new drug delivery devices and systems, and advanced evaluation procedures are presented.

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Section: Natural Products From Plants Used In Medical Devicesmentioning

confidence: 99%

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Isopencu,

Covaliu-Mierlă,

Deleanu

2023

Plants

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“…A promising alternative to traditional methods involves the utilization of plant extracts, offering several advantages, including biodegradability, diverse biological activities, complex chemical diversity, and varied mechanisms of action. This minimizes the likelihood of pathogens developing resistance [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Phytoconstituents and Ergosterol Biosynthesis-Targeting Antimicrobial Activity of Nutmeg (Myristica fragans Houtt.) against Phytopathogens

Cruz,

Sánchez-Hernández,

Teixeira

et al. 2024

Molecules

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In recent years, nutmeg (Myristica fragans Houtt.) has attracted considerable attention in the field of phytochemistry due to its diverse array of bioactive compounds. However, the potential application of nutmeg as a biorational for crop protection has been insufficiently explored. This study investigated the constituents of a nutmeg hydroethanolic extract via gas chromatography-mass spectrometry and vibrational spectroscopy. The research explored the extract’s activity against phytopathogenic fungi and oomycetes, elucidating its mechanism of action. The phytochemical profile revealed fatty acids (including tetradecanoic acid, 9-octadecenoic acid, n-hexadecanoic acid, dodecanoic acid, and octadecanoic acid), methoxyeugenol, and elemicin as the main constituents. Previously unreported phytochemicals included veratone, gelsevirine, and montanine. Significant radial growth inhibition of mycelia was observed against Botrytis cinerea, Colletotrichum acutatum, Diplodia corticola, Phytophthora cinnamomi, and especially against Fusarium culmorum. Mode of action investigation, involving Saccharomyces cerevisiae labeled positively with propidium iodide, and a mutant strain affected in ERG6, encoding sterol C-24 methyltransferase, suggested that the extract induces a necrotic type of death and targets ergosterol biosynthesis. The evidence presented underscores the potential of nutmeg as a source of new antimicrobial agents, showing particular promise against F. culmorum.

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“…As a result, alternative methods for controlling plant disease and minimizing the harmful effects of synthetic fungicides have been developed, including biological control through the use of natural compounds having antimicrobial properties. This includes the use of medicinal plant extracts and essential oils 14 .…”

Section: Introductionmentioning

confidence: 99%

Silver nanoparticles improve the fungicidal properties of Rhazya stricta decne aqueous extract against plant pathogens

Al-Sahli,

Al-Otibi,

Alharbi

et al. 2024

Sci Rep

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One of the most promising, non-toxic, and biocompatible developments for many biological activities is the green synthesis of nanoparticles from plants. In this work, we investigated the antifungal activity of silver nanoparticles (AgNPs) biosynthesized from Rhazya stricta aqueous extract against several plant pathogenic fungi. UV–visible spectroscopy, Zeta potential analysis, Fourier-transform infrared spectroscopy (FTIR), and transmitted electron microscopy (TEM) were used to analyze the biosynthesized AgNPs. Drechslera halodes, Drechslera tetramera, Macrophomina phaseolina, Alternaria alternata, and Curvularia australiensis were tested for their potential antifungal activity. Surface Plasmon Resonance (SPR) of Aq. AgNPs and Alkaline Aq. AgNPs was observed at 405 nm and 415 nm, respectively. FTIR analysis indicated hydroxyl, nitrile, amine, and ketone functional groups. Aq. AgNPs and Alka-line Aq. AgNPs had velocities of − 27.7 mV and − 37.9 mV and sizes of 21–90 nm and 7.2–25.3 nm, respectively, according to zeta potential studies and TEM. The antifungal examination revealed that all species' mycelial development was significantly inhibited, accompanied by severe ultra-structural alterations. Among all treatments, Aq. AgNPs were the most effective fungicide. M. phaseolina was statistically the most resistant, whereas A. alternata was the most vulnerable. To the best of our knowledge, this is the first report on R. stricta's antifungal activity against these species.

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Phytochemicals as alternative fungicides for controlling plant diseases: A comprehensive review of their efficacy, commercial representatives, advantages, challenges for adoption, and possible solutions

Cited by 38 publications

References 54 publications

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Phytoconstituents and Ergosterol Biosynthesis-Targeting Antimicrobial Activity of Nutmeg (Myristica fragans Houtt.) against Phytopathogens

Silver nanoparticles improve the fungicidal properties of Rhazya stricta decne aqueous extract against plant pathogens

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