Phytochemicals Against Drug-Resistant Microbes

Simões, Manuel; Lemos, Madalena; Simões, Lúcia C.

doi:10.1007/978-94-007-3926-0_6

Cited by 15 publications

(10 citation statements)

References 137 publications

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“…Bacterial infections are one of the leading causes of infectious diseases in Africa. Poverty and poor health infrastructure continue to be an impediment to effective health care service delivery [ 1 ]. On a global scale, life-threatening infections caused by these pathogenic prokaryotic microorganisms have become an important cause of morbidity and mortality in immune-compromised patients in developing countries [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…The worldwide escalation in both community- and hospital-acquired antimicrobial bacteria is threatening the effective treatment of patients, emphasizing the need for continued surveillance, prudent infection control, and new treatment alternatives [ 17 ]. Antibiotic resistant bacteria are increasingly prevalent and new antimicrobials are needed to control these pathogens yet development of resistance is unavoidable as it is a pivotal aspect of microbial evolution [ 1 ]. Thus, there is an urgent need for development of novel antibacterial products that act on molecular targets that act against bacterial resistance mechanisms.…”

Section: Introductionmentioning

confidence: 99%

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Antibacterial Properties of Alkaloid Extracts from Callistemon citrinus and Vernonia adoensis against Staphylococcus aureus and Pseudomonas aeruginosa

Mabhiza

Chitemerere

Mukanganyama

2016

International Journal of Medicinal Chemistry

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The development of new antibiotics from new chemical entities is becoming more and more expensive, time-consuming, and compounded by emerging strains that are drug resistant. Alkaloids are plant secondary metabolites which have been shown to have potent pharmacological activities. The effect of alkaloids from Callistemon citrinus and Vernonia adoensis leaves on bacterial growth and efflux pump activity was evaluated on Staphylococcus aureus and Pseudomonas aeruginosa. At a concentration of 1.67 mg/mL, the alkaloids inhibited bacterial growth with comparable effects to ampicillin, a standard antibiotic. The alkaloids from C. citrinus were the most potent against S. aureus with an MIC of 0.0025 mg/mL and MBC of 0.835 mg/mL. It was shown that effects on P. aeruginosa by both plant alkaloids were bacteriostatic. P. aeruginosa was most susceptible to drug efflux pump inhibition by C. citrinus alkaloids which caused an accumulation of Rhodamine 6G of 121% compared to the control. Thus, C. citrinus alkaloids showed antibacterial activity as well as inhibiting ATP-dependent transport of compounds across the cell membrane. These alkaloids may serve as potential courses of compounds that can act as lead compounds for the development of plant-based antibacterials and/or their adjunct compounds.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Antibacterial Properties of Alkaloid Extracts from Callistemon citrinus and Vernonia adoensis against Staphylococcus aureus and Pseudomonas aeruginosa

Mabhiza

Chitemerere

Mukanganyama

2016

International Journal of Medicinal Chemistry

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“…The emergence of antimicrobial resistance and the limited efficacy of current antifungal agents have motivated the exploration for new drugs with relatively low toxicity that can reduce the chances of developing resistance (10)(11)(12).…”

mentioning

confidence: 99%

Synergistic Effect of the Flavonoid Catechin, Quercetin, or Epigallocatechin Gallate with Fluconazole Induces Apoptosis in Candida tropicalis Resistant to Fluconazole

Silva

Neto

Campos

et al. 2014

Antimicrob Agents Chemother

107

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“…These compounds are considered to have potential as new antimicrobial drugs [4,5]. A number of natural polypeptides that are produced by plants has recently become the subject of intensive research [6][7][8] marking the beginning of an investigation into this large group of prospective antimicrobial compounds.…”

Section: Introductionmentioning

confidence: 99%

Hypothesis: daptomycin permeabilizes membranes by forming self assembled nanotubes

Zhivich

2020

Microbiology Independent Research Journal (MIR Journal)

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Daptomycin is the only lipopeptide antibiotic that is widely used in clinical practice. It was discovered by Eli Lilly and then studied and commercialized by Cubist Pharmaceuticals in 2003. Although this antibiotic has been used for 17 years, the debate over its mechanism of action is ongoing. In this paper, we discuss the different hypotheses on the mode of action of this antibiotic with a primary focus on the bacterial membrane permeabilization as the main mechanism of action. By comparing the experimental data on the oligomerization of daptomycin in membranes with properties of self-assembling cyclic peptides, we conclude that the structure of daptomycin oligomer should resemble the structures of peptide nanotubes that serve as ion channels in membranes.

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Phytochemicals Against Drug-Resistant Microbes

Cited by 15 publications

References 137 publications

Antibacterial Properties of Alkaloid Extracts from Callistemon citrinus and Vernonia adoensis against Staphylococcus aureus and Pseudomonas aeruginosa

Antibacterial Properties of Alkaloid Extracts from Callistemon citrinus and Vernonia adoensis against Staphylococcus aureus and Pseudomonas aeruginosa

Synergistic Effect of the Flavonoid Catechin, Quercetin, or Epigallocatechin Gallate with Fluconazole Induces Apoptosis in Candida tropicalis Resistant to Fluconazole

Hypothesis: daptomycin permeabilizes membranes by forming self assembled nanotubes

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