Phytochemicals

Thakur, Monika; Singh, Karuna; Khedkar, Renu

doi:10.1016/b978-0-12-818593-3.00011-7

Cited by 56 publications

(22 citation statements)

References 63 publications

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“…Often, when the various phytocomplex constituents are isolated, their biological activities are minimal, while the effects of the whole phytocomplex as it is in the plant are remarkable [11]. Dietary intake of phytochemicals with nutraceutical properties promotes health benefits and protects the body against numerous diseases, including cancers, coronary heart disease, diabetes, high blood pressure, inflammation, microbial viral and parasitic infections, psychotic disease, spasmodic conditions, ulcers, and osteoporosis [12]. Furthermore, phytochemicals may represent a new nutraceutical therapeutic approach to preventing or mitigating diet-related diseases, which are becoming more common in Western societies because of the increased availability of calorie-rich foods and a sedentary lifestyle [13].…”

Section: Discussionmentioning

confidence: 99%

Cydonia oblonga Mill. Pulp Callus Inhibits Oxidative Stress and Inflammation in Injured Cells

Gubitosa,

Fraternale,

De Bellis

et al. 2023

Antioxidants

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The pharmacological activity of a callus extract from the pulp of Cydonia oblonga Mill., also known as quince, was investigated in murine macrophage (RAW 264.7) and human keratinocyte (HaCaT) cell lines. In particular, the anti-inflammatory activity of C. oblonga Mill. pulp callus extract was assessed in lipopolysaccharides (LPS)-treated RAW 264.7 by the Griess test and in LPS-treated HaCaT human keratinocytes by examining the expression of genes involved in the inflammatory process, including nitric oxide synthase (iNOS), interleukin-6 (IL-6), interleukin-1β (IL-1β), nuclear factor-kappa-B inhibitor alfa (ikBα), and intercellular adhesion molecule (ICAM). The antioxidant activity was evaluated by quantizing the reactive oxygen species (ROS) production in the hydrogen peroxide and tert-butyl hydroperoxide-injured HaCaT cell line. The obtained results indicate that C. oblonga callus from fruit pulp extract has anti-inflammatory and antioxidant activities, suggesting its possible application in delaying and preventing acute or chronic diseases associated with aging or in the treatment of wound dressing.

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Section: Discussionmentioning

confidence: 99%

Cydonia oblonga Mill. Pulp Callus Inhibits Oxidative Stress and Inflammation in Injured Cells

Gubitosa,

Fraternale,

De Bellis

et al. 2023

Antioxidants

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“…Phytochemicals such as curcumin, crocin, berberine, anthocyanin, catechin, resveratrol, and others, are bioactive nutrients naturally contained in plant foods having the potential to reduce plasma TG levels (Thakur, Singh, & Khedkar, 2020). These bioactive compounds are extra nutritional constituents and in small quantities exist in foods and, based on dosage, may have beneficial effects on human health (Vasanthi, ShriShriMal, & Das, 2012).…”

Section: Introductionmentioning

confidence: 99%

The effects of phytochemicals on serum triglycerides in subjects with hypertriglyceridemia: A systematic review of randomized controlled trials

Tehrani

Shojaei

Bagherniya

et al. 2023

Phytotherapy Research

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This systematic review aimed to evaluate the efficacy of phytochemicals on lipid parameters in patients with hypertriglyceridemia (HTG). A comprehensive search was performed in PubMed/Medline, Scopus, ISI Web of Science, and Google Scholar from inception up to October 2021 to recognize randomized controlled trials (RCTs) assessing the effects of phytochemicals on lipid profiles in patients with HTG. Forty-eight RCTs including 53 arms and comprising 3,478 HTG patients met the eligibility criteria. Phytochemicals significantly reduced the serum levels of triglycerides in 32 out 53 arms, total cholesterol in 22 out of 51, low-density lipoprotein cholesterol in 21 out of 48, very low-density lipoprotein cholesterol in 1 out of 5, apolipoprotein B in 2 out of 4, and lipoprotein(a) levels in 2 out of 4 arms. Furthermore, phytochemicals supplementation increased the levels of high-density lipoprotein cholesterol in 15 out of 48 arms. In brief, phytochemicals supplementation might have beneficial effects on HTG. In most of the studies, phytochemicals had a favorable effect on at least one of the lipid parameters.

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“…Polyphenols are divided into several sub-classes, such as phenolic acids, flavonoids (flavonols, flavones, flavanols, anthocyanidins, and isoflavones), stilbenes, and lignans, among others [ 3 , 4 ]. These compounds are well-known for their antioxidant properties [ 5 ] and for their ability to protect the organism against reactive oxygen species (ROS) [ 6 ], which are responsible of several pathologies such as neurodegenerative, lung, and cardiovascular diseases, diabetes, and atherosclerosis [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Dragon’s Blood Sap Microencapsulation within Whey Protein Concentrate and Zein Using Electrospraying Assisted by Pressurized Gas Technology

Escobar-García¹,

Prieto

Pardo-Figuerez

et al. 2023

Molecules

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Dragon’s blood sap (DBS) obtained from the bark of Croton lechleri (Müll, Arg.) is a complex herbal remedy of pharmacological interest due to its high content in polyphenols, specifically proanthocyanidins. In this paper, electrospraying assisted by pressurized gas (EAPG) was first compared with freeze-drying to dry natural DBS. Secondly, EAPG was used for the first time to entrap natural DBS at room temperature into two different encapsulation matrices, i.e., whey protein concentrate (WPC) and zein (ZN), using different ratios of encapsulant material: bioactive compound, for instance 2:1 w/w and 1:1 w/w. The obtained particles were characterized in terms of morphology, total soluble polyphenolic content (TSP), antioxidant activity, and photo-oxidation stability during the 40 days of the experiment. Regarding the drying process, EAPG produced spherical particles with sizes of 11.38 ± 4.34 µm, whereas freeze-drying produced irregular particles with a broad particle size distribution. However, no significant differences were detected between DBS dried by EAPG or freeze-drying in TSP, antioxidant activity, and photo-oxidation stability, confirming that EAPG is a mild drying process suitable to dry sensitive bioactive compounds. Regarding the encapsulation process, the DBS encapsulated within the WPC produced smooth spherical microparticles, with average sizes of 11.28 ± 4.28 µm and 12.77 ± 4.54 µm for ratios 1:1 w/w and 2:1 w/w, respectively. The DBS was also encapsulated into ZN producing rough spherical microparticles, with average sizes of 6.37 ± 1.67 µm and 7.58 ± 2.54 µm for ratios 1:1 w/w and 2:1 w/w, respectively. The TSP was not affected during the encapsulation process. However, a slight reduction in antioxidant activity measured by DPPH was observed during encapsulation. An accelerated photo-oxidation test under ultraviolet light confirmed that the encapsulated DBS showed an increased oxidative stability in comparison with the non-encapsulated DBS, with the stability being enhanced for the ratio of 2:1 w/w. Among the encapsulating materials and according to the ATR-FTIR results, ZN showed increased protection against UV light. The obtained results demonstrate the potential of EAPG technology in the drying or encapsulation of sensitive natural bioactive compounds in a continuous process available at an industrial scale, which could be an alternative to freeze-drying.

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Phytochemicals

Cited by 56 publications

References 63 publications

Cydonia oblonga Mill. Pulp Callus Inhibits Oxidative Stress and Inflammation in Injured Cells

Cydonia oblonga Mill. Pulp Callus Inhibits Oxidative Stress and Inflammation in Injured Cells

The effects of phytochemicals on serum triglycerides in subjects with hypertriglyceridemia: A systematic review of randomized controlled trials

Dragon’s Blood Sap Microencapsulation within Whey Protein Concentrate and Zein Using Electrospraying Assisted by Pressurized Gas Technology

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