Phytochemical study of Stachys sylvatica (Lamiaceae) aerial parts

Anthelminthic and antimicrobial effects of hedge woundwort (Stachys sylvatica L.) growing in Southern Kazakhstan

“…Previously other authors showed the presence of a rich variety of metabolites in Stachys sylvatica L. extracts. The chloroform, chloroform-methanol and methanolic extracts prepared from aerial parts of S. sylvatica L. collected in Tuscan-Emilian Apenine (Italy) were investigated, followed by the identification of 23 metabolites belonging to the phenolic derivatives, glycosylated aliphatic alcohols, glycosylated phenylpropanoids, flavonoids, lignans, ionones and carboxylic acids ( Di Stasi et al, 2023 ). In other studies concerning S. sylvatica L. growing in Romania the hydromethanolic extracts (80% v/v) obtained from flowers, leaves and stems were analyzed separately.…”

“…These extracts were rich in phenolic metabolites, including chlorogenic acid. The content of polyphenols in flowers, leaves and stems differed greatly, being 2119.69, 333.25 and 113.38 μg/g, respectively ( Apostolescu et al, 2023 ; Di Stasi et al, 2023 ).…”

“…The chemical profile obtained for the investigated SSE partially differs from other S. sylvatica L. extracts, where all investigated samples were derived from plants growing in Europe (Italy or Romania). Phenolcarboxylic acids, mostly chlorogenic acid, caffeic acid and rosmarinic acid, are often found metabolites in S. sylvatica L. ( Apostolescu et al, 2023 ; Benedec et al, 2023 ; Di Stasi et al, 2023 ). While in our extract chlorogenic acid was found, no remaining two acids were identified.…”

“…While in our extract chlorogenic acid was found, no remaining two acids were identified. Additionally, quantitative analysis revealed that S. sylvatica L. collected in Kazakhstan is rich in numerous chlorogenic acid derivatives, e.g., isochlorogenic acid or cryptochlorogenic acid, rarely reported in samples collected in other parts of the world ( Benedec et al, 2023 ; Di Stasi et al, 2023 ). However, it is worth mentioning that chlorogenic acid derivatives were reported in research including other Stachys species, e.g., isochlorogenic acid was found in S. officinalis L. ( Vundać et al, 2005 ; Kanjevac et al, 2023 ), while neochlorogenic and cryptochlorogenic acids in S. palustris L. ( Kartsev et al, 1994 ).…”

“…Among the most biologically active secondary metabolites, there are polyphenols, iridoids, terpenoids, fatty acids, alkaloids, triterpenes and many others, represented by more than 200 metabolites ( Bilušić, 2019 ; Tomou et al, 2020 ). However, there are only scarce data on Stachys sylvatica L. derived mostly from Balkan Peninsula region ( Hajdari et al, 2012 ; Jassbi et al, 2014 ; Dimitrova et al, 2015 ; Bilušić, 2019 ; Apostolescu et al, 2023 ; Di Stasi et al, 2023 ).…”