Phytochemical Study, Antioxidant and Antimicrobial Activities of Euphorbia Resinifera L.

Benmehdi, Houcine; Bounoua, Nadia; Amrouche, A.; Lahcene, Driss; Maazouzi, Abdelhak

doi:10.7897/2230-8407.04910

Cited by 10 publications

(20 citation statements)

References 30 publications

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“…In this study, the preliminary phytochemical analyses of the extracts of the aerial parts of ER have shown the presence of flavonoids and tannins, and there was no saponins or alkaloids like described by Benmehdi et al, 5 for ER from Algeria. Some studies have noted changes in total alkaloid substances in response to nitrogenous fertilizer 27 .…”

Section: Fig 3: Effect Of Oral Administration Of Euphorbia Resinifersupporting

confidence: 57%

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2019

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Euphorbia resinifera Berg. (ER) an endemic Moroccan plant has been used to treat different diseases. In spite of its toxicological potential, no scientific report until now was made to evaluate in-vivo neither the toxic effect nor its immunomodulatory activity. The objective was to evaluate the safety of an aqueous extract (AE) of ER in-vivo and its effect on the biochemical, immunological and histopathological parameters. The AE was administrated in single oral dose (5g/kgbw) for the acute toxicity tests given daily by gavages at 0.1, 0.5, 1, 2.5, or 5 g/kg for 28 consecutive days. Serum was analyzed for creatinine, urea, alanine aminotransferase, and aspartate aminotransferase. Histopathological examination of liver, kidneys, and spleen was done at the end of the study. The immunological effect was tested by the evaluation of antibodies production and the level of the delayed type hypersensitivity reaction. No signs of toxicity or deaths were observed in mice treated by a single dose. In the sub-acute toxicity tests, no visible toxic effects were observed at 0.1-1 g/kg doses. However, at 2.5 and 5 g/kg doses, the mice showed some behavioral signs of toxicity. This was confirmed by the histological and biochemical evaluations. When tested against SRBC, there was a significant increase of "haemagglutinating antibody titer" and in "delayed-type hypersensitivity" response in mice treated by ER at 1 g/kg bw (4 and 1.5 times respectively p<0.05). Higher than 2.5 g/kg, the ER can cause liver and kidney toxicity. The immune-stimulatory effect was induced by an inflammatory reaction. QUICK RESPONSE CODE

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Section: Fig 3: Effect Of Oral Administration Of Euphorbia Resinifersupporting

confidence: 57%

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2019

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“…The mixture was left on for few minutes until the end of the reaction. The presence of Flavonoids is confirmed if a pink, red or purple color develops in the course of 3 minutes 10,14,15 .…”

Section: Test For Alkaloidsmentioning

confidence: 99%

“…The residue was then dissolved in 1.5 mL of HCl 2 % and treated with two drops of Mayer's reagent. Turbidity and formation of creamy white precipitate was regarded as evidence for the presence of free alkaloids in the extract 15 and all results were compared with blanks. 10ml of the etheric solution were evaporated to dryness using a rotavapor.…”

Section: Test For Alkaloidsmentioning

confidence: 99%

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Phytochemical Screening and Antifungal Activity of Saponin Extract From Algerian Silene Hoggariensis Quezel

Amrouche¹,

Benmehdi²,

Sari³

et al. 2014

Int. Res. J. Pharm.

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This study aims to investigate the presence of active phytochemical compounds of Silene hoggariensis Quezel and to assess the antifungal activity of saponin extracts. Plant sample was collected from Adrar department (south Algeria), the phytochemical screening was conducted on the arial part by three solvents. The saponin extracts were screened for antifungal activity against Aspergillus flavus, Aspergillus ochraceus, Fusarium oxysporium and Penicillium expansum using two methods: inhibition of radial growth on solid medium (PDAa) and inhibition of biomass on liquid medium (PDB). The phytochemical analysis revealed the presence of various secondary metabolites of therapeutically importance. The major phytochemicals found were saponins (3.2%), tannin (0.08%) and alkaloids (0.01%). The in vitro antifungal assay of the saponins exhibit antifungal potency against fungal strains tested with varied effectiveness. Higher antifungal inhibition was observed on Fusarium oxysporium (IAF: 40.69%), and Penicillium expansum (IAF: 36.20%). Less antifungal effect of saponins was observed for Aspergillus ochraceus and Aspergillus flavus. The results provided evidence that the studied saponin extract might indeed be potential sources of natural antifungal agents.

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“…The extract was mixed with 3.0 ml DPPH (0.5 m mol/ L) in methanol, the resultant absorbance was recorded at 517 nm after 30 minute incubation at 37˚C [22][23][24] . The percentage of scavenging activity was derived using the following formula, …”

Section: Dpph Radical Scavenging Activitymentioning

confidence: 99%

Phytochemical and Pharmacological Evaluation of Barleria Grandiflora

Sawarkar¹,

Dhongade²,

Pandey³

et al. 2015

Int. Res. J. Pharm.

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Introduction: The juice of leaves of Barleria grandiflora has been used by folk across central region of India for the treatment of oral ulcers. The objective of the study is to determine the antioxidant and the antibacterial activity of ethanolic extract of leaves of Barleria grandiflora Dalz (Acanthaceae). Materials and Methods: Phytochemical screening was carried out as per the usual chemical tests. The TLC was carried out to determine the constituents which might be similar to Barleria prionitis. Total phenolic content was determined using Folin-Ciocalteau method. Antioxidant activity was performed by using hydrogen peroxide radical scavenging method and DPPH (1, 1-Diphenyl-2-picrylhydrazyl) radical scavenging activity. Antibacterial activity was carried using agar well diffusion method. Results: Phytochemical screening had shown the presence of carbohydrates, proteins, alkaloids, glycosides, phenolic compounds and flavanoids in ethanolic extracts of leaves of the plant. The total phenolic content was found to be 75.44 mg/10ml. Barleria grandiflora was found to have antioxidant potential comparable to ascorbic acid (vitamin c). It was also found that the ethanolic extract of Barleria grandiflora shows significant antibacterial activity. Zones of inhibition of ethanolic extract of Barleria grandiflora were found comparable to that of standard. Conclusion: Ethanolic extract of leaves of Barleria grandiflora exhibited antioxidant and antibacterial activity which may be the reason for the use of juice of Barleria grandiflora leaves in the treatment of mouth ulcers by some folk.

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Phytochemical Study, Antioxidant and Antimicrobial Activities of Euphorbia Resinifera L.

Cited by 10 publications

References 30 publications

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Phytochemical Screening and Antifungal Activity of Saponin Extract From Algerian Silene Hoggariensis Quezel

Phytochemical and Pharmacological Evaluation of Barleria Grandiflora

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