Phytochemical study and biological activities of Scurrula parasitica L (Loranthaceae) leaves

Muhammad, Kamal Ja’afar; Jamil, Shajarahtunnur; Basar, Norazah

doi:10.12991/jrp.2019.159

Cited by 5 publications

(6 citation statements)

References 24 publications

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“…In southern Ecuador, is has been located in different sites, such as Cajanuma and Saraguro, among others [10]. The Loranthaceae family has been reported to have anti-inflammatory [11], antioxidant [12,13], antimalarial [14], antimicrobial, antiviral [15], and gastrointestinal properties [16]. Some studies performed in this family have reported the presence of glycosylated flavonoids [17] and cardiac glucosides [18].…”

Section: Introductionmentioning

confidence: 99%

Novel Flavonoid Glycosides of Quercetin from Leaves and Flowers of Gaiadendron punctatum G.Don. (Violeta de Campo), used by the Saraguro Community in Southern Ecuador, Inhibit α-Glucosidase Enzyme

et al. 2019

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Gaiadandendron punctatum G.Don. (violeta de campo) is a plant used in traditional medicine by the Saraguro people, an ancient indigenous group that lives in southern Ecuador. From samples collected in the region, six glycoside flavonoids, five with quercetin and one with kaempferol as aglycon, were isolated and characterized from hydroalcoholic extracts of leaves and flowers. Rutin (2) was found in flowers and leaves, nicotiflorin (1) was found in flowers, artabotryside A (3) was found in leaves, and three novel quercetin flavonoid glycosides were isolated, elucidated, and characterized via 1D and 2D NMR experiments (1H, 13C, COSY, DEPT, HMBC, HSQC, TOCSY, NOESY, ROESY), acid hydrolysis–derivatization–GC-MS analysis, HPLC-MS, IR, UV, and optical rotation. The new quercetin flavonoid glycosides were named hecpatrin (4) (isolated from leaves), gaiadendrin (5) (isolated from leaves), and puchikrin (6) (isolated from flowers). The hydroalcoholic extracts of the leaves presented antimicrobial activity against Micrococcus luteus, Staphylococcus aureus, and Enterococcus faecalis and the hydroalcoholic extract of the flowers was active against Micrococcus luteus. However, glycoside flavonoids presented scarce antimicrobial activity against bacteria. Hydroalcoholic extracts from leaves and flowers and their secondary metabolites showed inhibition against the α-glucosidase enzyme at different concentrations. Rutin, gaiadendrin, and nicotiflorin showed competitive α-glucosidase inhibition, while hecpatrin presented non-competitive inhibition.

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Section: Introductionmentioning

confidence: 99%

Novel Flavonoid Glycosides of Quercetin from Leaves and Flowers of Gaiadendron punctatum G.Don. (Violeta de Campo), used by the Saraguro Community in Southern Ecuador, Inhibit α-Glucosidase Enzyme

et al. 2019

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“…Tiegh., a semiparasitic plant grown in Saudi Arabia, traditionally used as a cure for diabetes and cancer in human, a flavonoid quercetin, (-)-catechin, and a flavane gallate 2S,3R-3,3´,4´,5,7pentahydroxyflavane-5-O-gallate, were isolated from the aerial parts (Orfali et al, 2019). Cold extractions of S. parasitica leaves were carried out using n-hexane, ethyl acetate and metanol to obtain the crude extracts, and purification of the extracts led to isolation of quercetin, quercitrin, kaempferol 3-O-α-L-rhamnoside, (+)-catechin, lupeol 5, lupeol palmitate, ꞵ-sitosterol, squalene, octacosane, octadecane and eicosane (Muhammad et al, 2019). Only polyphenols and four flavonoids, two glycosidated (kaempherol glicoside and quercetin glicoside) and two non-glycosidated (kaempherol and quercetin), were detected in the study carried out on P. linearis, without deepening in the isolation and identification of other secondary metabolites.…”

Section: Discussionmentioning

confidence: 99%

“…and Pseudomonas sp., all of which are known to be associated with either crown gall or gastrointestinal tract and wound infections (Deeni & Sadiq, 2002). Likewise, all extracts and isolated compounds of S. parasitica leaves showed weak activity on antimicrobial activity against two Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis), two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa) and a fungi (Aspergillus niger) with the exception of quercetin which exhibited moderate activity against P. aeruginosa with MIC and MBC value of 250 μg/mL (Muhammad et al, 2019). In the study with P. linearis, although the results were only significant with strains of Staphylococcus aureus, its is necessary to carry out other tests with different strains of bacterial species of wide prevalence in hospital infections.…”

Section: Discussionmentioning

confidence: 99%

“…Likewise, the cloroform fraction and crude extract from Loranthus acaciae Zucc grown in Saudi Arabia showed anti-diabetic, anti-inflammatory and antioxidant activities (Noman et al, 2019). Leaves from Scurrula parasitica L., quercetin, quercitrin, kaempferol 3-O-α-Lrhamnoside, (+)-catechin compounds, together with ethyl acetate and methanol extracts exhibited effective antioxi-dant activities against DPPH(2,2-diphenyl-1-picrylhydrazyl), ABTS[2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)] and FRAP (Ferric reducing antioxidant potential), while n-hexane and other compounds were inactive (Muhammad et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

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In vitro tissue culture, preliminar phytochemical analysis, and antibacterial activity of Psittacanthus linearis (Killip) J.K. Macbride (Loranthaceae)

Bollona

Delgado-Paredes

Wagner

et al. 2019

Rev. colomb. biotecnol.

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Hemiparasitic plants commonly known as mistletoe (muérdago in Spanish) in the families Santalaceae and Loranthaceae are common in various kinds of plants or trees, and many hemiparasitic plants are used for medicinal purposes in various parts of the world. The objective of the present work, carried out in Psittacanthus linearis (suelda con suelda), a representative species in the seasonally dry forest (SDF) from the north of Perú, was to study aspects of in vitro tissue culture, carry out preliminary phytochemical analysis, and assess antibacterial activity. Seeds of individuals of P. linearis, which used Prosopis pallida (algarrobo) as host plant, were collected and used to induce in vitro seed germination, clonal propagation, callus induction and organogenesis. Stems, leaves and fruits of individuals of P. linearis were dried, powdered, and subjected to ethanol extraction. Posteriorly the extract was first recovered with ethanol and the remnant with chloroform, which formed the ethanolic and chloroformic fraction. A preliminary phytochemical screening was performed and preliminary antibacterial studies with Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa were carried out and their results are discussed. This is the first report about in vitro tissue culture, phytochemical analysis and antibacterial activity of P. linearis. The results may have important implications for understanding physiological and biochemical interactions between host and hemiparasitic species as well as P. linearis with P. pallida and other SDF species.

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“…These Petri dishes were kept as it is for one-hour diffusion at room temperature and then for incubation at 37 0 C for 24 hours in an incubator. The extent diameter of inhibition after 24 hours was measured as the zone of inhibition in millimeters [16][17][18][19].…”

Section: Antibacterial Activitymentioning

confidence: 99%

Synthesis, Characterization and Biological Evaluation of some Novel Substituted Indole-Coumarin Derivatives as Potential Antibacterial and Antifungal Agents

Vawhal¹,

Jadhav²

2021

JPRI

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Aim: In the present work, we have designed and synthesized indole-fused coumarin derivatives as potential antibacterial and antifungal agents. Place and Duration of Study: The present work was carried out at PEA's Modern college of Pharmacy, Sector 21, Yamunanagar, Nigdi- 411044 between the duration of January-2021 to May-2021. Methodology: The in vitro antibacterial and antifungal activity was performed by disc diffusion method. The antibacterial activities were tested using agar nutrient medium against Bacillus subtilis, Bacillus pumilus, Escherichia coli, and Pseudomonas aeruginosa that are representative types of gram-positive and gram-negative organisms respectively. The anti-fungal activity of all the compounds were determined on potato dextrose agar medium against Aspergillus niger and Candida albicans. Clotrimazole 100 μg/ml was used as a standard and DMF was used as control. Results: It was observed that all the compounds were sensitive to the gram +ve bacteria. Compound 2c, 2e, and 2f were sensitive to gram –ve bacteria. Compounds 2a, 2b, and 2f were sensitive to both the fungal strains while all the derivatives were sensitive to Candida albicans. Conclusion: From present investigation it has been observed that compound 2f was sensitive against gram +ve, gram –ve, and both the strains of fungal strains. Structurally, compound 2f possess aldehyde functional group at indole nucleus. Therefore, from present study we have concluded that compound 2f is a lead molecule for the further development of potential antibacterial and antifungal agents.

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Phytochemical study and biological activities of Scurrula parasitica L (Loranthaceae) leaves

Cited by 5 publications

References 24 publications

Novel Flavonoid Glycosides of Quercetin from Leaves and Flowers of Gaiadendron punctatum G.Don. (Violeta de Campo), used by the Saraguro Community in Southern Ecuador, Inhibit α-Glucosidase Enzyme

Novel Flavonoid Glycosides of Quercetin from Leaves and Flowers of Gaiadendron punctatum G.Don. (Violeta de Campo), used by the Saraguro Community in Southern Ecuador, Inhibit α-Glucosidase Enzyme

In vitro tissue culture, preliminar phytochemical analysis, and antibacterial activity of Psittacanthus linearis (Killip) J.K. Macbride (Loranthaceae)

Synthesis, Characterization and Biological Evaluation of some Novel Substituted Indole-Coumarin Derivatives as Potential Antibacterial and Antifungal Agents

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