Phytochemical Study and Anti-inflammatory, Antidiabetic and Free Radical Scavenger Evaluations of Krameria pauciflora Methanol Extract

Abstract

The plant Krameria pauciflora MOC et. Sessé ex DC. is used as an anti-inflammatory and antidiabetic in traditional medicine. The aim of this study was to evaluate the in vivo anti-inflammatory and antidiabetic effects of a methanol extract from the roots of K. pauciflora. Dichloromethane and ethyl acetate extracts obtained by partitioning the methanol extract were also evaluated. Complete methanol and dichloromethane extracts showed anti-inflammatory effects at 3 mg/kg. An anti-inflammatory effect similar to indomethacin (10 mg/kg) was observed when the methanol and dichloromethane extracts, which contain a cycloartane-type triterpene and an sterol, were administered orally at several doses (3, 10, 30 and 100 mg/kg), whereas no anti-inflammatory effect was observed at any dose for the ethyl acetate extract, which contains catechin-type flavonoids. The antidiabetic effect of each extract was also determined. An antihyperglycaemic effect was observed in diabetic rats, but no effect in normoglycaemic animals was observed when the methanol extract was administrated at 30 mg/kg. All of the extracts exhibited radical scavenger activity. Additionally, constituents from all of the extracts were identified by NMR. This article supports the use of K. pauciflora as an anti-inflammatory because it exhibits a similar effect to indomethacin. However, its antidiabetic effect is not completely clear, although it could be useful for preventing diabetic complications.

Phenolic contents-based assessment of therapeutic potential of Syzygium cumini leaves extract

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“…Non-steroidal anti-inflammatory drugs (NSAIDS) which are used for the treatment of inflammatory diseases are considered among the best-selling drugs worldwide despite the side effects associated with their use. Various plants with anti-inflammatory effects are used as alternative for the treatment of inflammation and thousands of reports exist on the anti-inflammatory properties of various plant tissue extracts [12]. Antidepressant drugs used as pain reliever in the cure of various chronic diseases have been traditionally obtained from plant based compounds [13].…”

Synthesis and evaluation of 29-norcycloartane triterpenoids as α-glucosidase inhibitors

“…Phytochemical studies on this plant furnished the presence of cycloartane triterpenes (Zeid, 1998;Akihisa et al, 1997). Cycloartane-type triterpenoids and its derivatives exhibited cytotoxicity (Shen et al, 2008;Kashiwada et al, 2011;Yang and Shi, 2012), anti-HIV (Kuo et al, 2009;Sun et al, 2011), antituberculosis (Truong et al, 2011), antiangiogenic (Pudhom et al, 2012), anticomplementary activity , anti-inflammatory and antidiabetic effects (Ramírez-Cisneros et al, 2012).…”

Coconut water of different maturity stages ameliorates inflammatory processes in model of inflammation

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