Phytochemical screening, antioxidant, antiulcer and toxicity studies on &lt;i&gt;Desmodium adscendens &lt;/i&gt;(Sw) DC Fabaceae leaf and stem

Ayoola, Gloria A.; Eze, Samuel O; Johnson, Oluwatosin O.; Adeyemi, D.K.

doi:10.4314/tjpr.v17i7.11

Cited by 7 publications

(10 citation statements)

References 12 publications

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“…Desmodium adscendens confirmed the appearance of tyramine and hordenine [49]. A methanolic extract of Desmodium adscendens showed the presence of glycosides, flavonoids, saponins, tannin, and alkaloids [50]. Desmodium ramosissimum confirmed the appearance of flavonoids, anthocyanins, tannins, and saponins [51].…”

Section: Phytoconstituents Present In Desmodium Speciesmentioning

confidence: 86%

The biological active compounds and biological activities of Desmodium species from Indian region: a review

Joshi

Hakim

Patel

2023

Beni-Suef Univ J Basic Appl Sci

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Background India is a diverse source of medicinal and aromatic plants. Desmodium species are one among them having importance in curing many human diseases. This herbaceous plant's species diversity minimizes problems with its pharmaceutical or herbal formulation. As a result, a detailed analysis of the phytochemistry of the Desmodium genus will allow for the proper use of this plant. Main body This review explores the distribution of Desmodium species and their various biological activities. Worldwide, 17 Desmodium species are found, while 13 species of Desmodium are found in India. Plants are mainly used in ayurvedic preparation for curing various diseases. Phytochemical examination of Desmodium species indicated the presence of isoflavones, glycosyl-flavonoids, coumarone-chromones, pterocarpons, triterpenoids, saponins, tetrahydroiso-quinolones, phenylethylamines, indole-3-alkylamines, lipids, and alkaloids. These genera also display various pharmacological activities, including anti-inflammatory, anticancer, analgesic, depressive, antipyretic, antidepressant, anti-diabetic, and antioxidant properties. Also it is valuable for febrifuges, remedies for dysentery and liver disease, wound healing, ulcer, antidote against snake bites, catarrh, abscesses and eye diseases, abdominal tumor, asthma, fever, nasal polyps, menstrual disorder, fever, colds and helps in kidney problems. Conclusion This review describes the distribution of various Desmodium species recorded by a different author, focusing on species recorded in Gujarat, India. Again, the review helps in the documentation of bioactive compounds from the Desmodium genus that may help rectify multiple severe diseases. Furthermore, the numerous biological potencies of the specific bioactive substance may characterize the interest in various pharmaceuticals and cosmeceuticals sectors.

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Section: Phytoconstituents Present In Desmodium Speciesmentioning

confidence: 86%

The biological active compounds and biological activities of Desmodium species from Indian region: a review

Joshi

Hakim

Patel

2023

Beni-Suef Univ J Basic Appl Sci

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“…The volatiles extracted from the leaves included phytone (14.72%), caryophyllene oxide (11.32%), eudesma (7.41%), geraniol (5.42%), linalool (5.33%), palmitic acid (5.06%), α‐caryophyllene (4.76%), scytalone (3.83%), β‐ionone (3.47%), 2,2‐dimethyl‐hexanale (3.37%), pelargonaldehyde (3.26%), hyperforine (3.27%), 2‐pentyl furan (2.71%), oleic acid (2.68%), and 4‐azidoheptane (2.02%) (Ayoola et al., 2018) In another study, phytochemical investigation of a DA decoction resulted in the identification of flavonoids such as vicenin‐2, isoschaftoside, schaftoside, 2″‐ O ‐xylosylvitexin, 2″‐ O ‐pentosyl‐chexosylapigenin, and an O ‐hexosyl‐ C ‐hexosyl‐apigenin, tentatively identified as 2″‐ O ‐glucosyl‐vitexin (van Dooren et al., 2018). In addition, DA decoction possessed vitexin and isovitexin glycosides at high concentration: vitexin and the C‐glycosides thereof were investigated for their interaction at the gastrointestinal level (with simulation test) reporting the stability of the molecules (van Dooren et al., 2018).…”

Section: Phytochemistry Of Desmodium Speciesmentioning

confidence: 99%

Desmodium adscendens (Sw.) DC.: A magnificent plant with biological and pharmacological properties

et al. 2022

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Desmodium adscendens (Sw.) DC. is a plant of the Fabaceae family especially rich in flavonoids but also in alkaloids, terpenoids, steroids, phenols, phenylpropanoids, glycosides, and volatiles. This herb has been traditionally used in numerous countries all over the world for its pharmacological and biological properties (i.e., it has been used for the treatment of diarrheas, fever, epilepsy, asthma, leishmaniasis, gastroduodenal ulcer, diabetes, hepatic diseases, etc.). Given the wide uses of D. adscendens, this review summarizes all recent data on D. adscendens evaluating its phytochemistry as well as its ethno-traditional and pharmacological properties. In addition, an association between the phytocompounds of this plant and its potential mechanism of action in cellThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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“…Las especies del género Desmodium han mostrado ser relativamente seguras y no tóxicas, en un estudio para Desmodium molliculum, los resultados del bioensayo de toxicidad en Artemia salina Leach muestran una concentración letal media, DL50 de 100,427 ug/mL (Lozano et al 2001), en otro estudio se reporta un DL50 de 360 ug/ml en extracto acuoso y 15,088 ug/ml en extracto etanólico (Bussmann et al 2011); en el caso de Desmodium adscendens la estimación de letalidad del 50% (DL50) fue de 1.342,32 mg/kg de peso corporal, una indicación de que el extracto es relativamente no tóxico y seguro para el consumo teniendo en cuenta el alto valor de DL50 (Seriki et al 2019). Otro estudio reporta toxicidad aguda en el extracto de tallo de D. adscendens produjo una mortalidad del 28,57% en ratones a la dosis más alta de 20 g/kg peso corporal, mientras que no se observó muerte a dosis más bajas (Ayoola et al 2018) Para D. gangeticum, D. triflorum y D. triquetrum se reportó la toxicidad de las tres plantas en modelos animales (ratones) a diferentes dosis (50-2000 mg) se documentaron parámetros como picazón, peso corporal, reacción cutánea, hiperactividad o convulsiones Se observó sedación, hipotermia y mortalidad. No se observó mortalidad después de la administración oral de la dosis más alta (2000 mg/kg) de extracto.…”

Section: Toxicidadunclassified

Desmodium molliculum (Kunth) DC (Fabaceae); Perfil etnobotánico, fitoquímico y farmacológico de una planta andina peruana

Olascuaga-Castillo

Rubio‐Guevara

Valdiviezo-Campos

et al. 2020

Ethnobot. Res. App.

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Antecedentes: Desmodium molliculum conocida comúnmente como "pie de perro", "pata de perro", "chancas de comida", "muña" o "manayupa" es una planta andina peruana que crece entre los 1000-3500 msnm, es una hierba rastrera perteneciente al orden Fabales, familia Fabaceae y género Desmodium. Es originaria de los andes peruanos, sin embargo, se distribuye desde México a Sudamérica. El propósito de esta revisión es proporcionar información completa sobre la botánica, usos tradicionales, fitoquímica, investigación farmacológica y toxicología de Desmodium molliculum.Métodos: La búsqueda de información para la elaboración de esta revisión fue realizada en los motores de búsqueda y base de datos Scielo, PubMed, Scopus y Google Académico, los criterios de inclusión de la información fueron artículos originales y de revisión, tesis de grado y postgrado, no se descartaron resultados por año de publicación, los idiomas se redujeron a Español e Inglés.Resultados: Desmodium molliculum ha exhibido un amplio espectro de actividades farmacológicas como actividades cicatrizantes, antiasmáticas, antiinflamatorias, hepatoprotectoras, antibacterianas, anticonceptivas, antioxidantes entre otras.Conclusiones: Se concluye que desde un punto de vista etnofarmacológico, es necesario investigar los mecanismos bioquímicos y fisiológicos involucrados en los diferentes efectos biológicos exhibidos por esta especie, especialmente las acciones inmunomoduladoras, relajante del músculo liso y anticonceptivas de Desmodium molliculum. También es necesario buscar metabolitos secundarios individuales responsables de estas acciones y poder estudiar los mecanismos de acción, la biodisponibilidad, la farmacocinética y las vías fisiológicas con suficiente detalle.

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Phytochemical screening, antioxidant, antiulcer and toxicity studies on <i>Desmodium adscendens </i>(Sw) DC Fabaceae leaf and stem

Cited by 7 publications

References 12 publications

The biological active compounds and biological activities of Desmodium species from Indian region: a review

The biological active compounds and biological activities of Desmodium species from Indian region: a review

Desmodium adscendens (Sw.) DC.: A magnificent plant with biological and pharmacological properties

Desmodium molliculum (Kunth) DC (Fabaceae); Perfil etnobotánico, fitoquímico y farmacológico de una planta andina peruana

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