Phytochemical screening, antioxidant analyses, and in vitro and in vivo antimalarial activities of herbal medicinal plant - Rotheca serrata (L.) Steane &amp; Mabb.

Chanu, Wahengbam Kabita; Chatterjee, Aditi; Singh, Nalini; Nagaraj, Viswanathan Arun; Singh, Chingakham Brajakishor

doi:10.1016/j.jep.2023.117466

Cited by 4 publications

(1 citation statement)

References 62 publications

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“…These efforts are critical to achieving the WHO Global Technical Strategy for Malaria goal of reducing the malaria burden globally by 90% in 2030 [22]. The large deposits of bioactive compounds in medicinal plants [23][24][25][26][27][28][29][30], make them important sources for the identi cation of effective antimalarial therapeutic leads. Enantia chlorantha Oliv.…”

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confidence: 99%

Aqueous extract of Enantia chlorantha Oliv. demonstrates antimalarial activity and improves redox imbalance and biochemical alterations in mice

Evbuomwan,

Adeyemi,

Oluba

2024

Preprint

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Background: Malaria is an infectious oxidative disease, which has continued to cause inconceivable loss of lives every year, almost unabatedly. Currently, it has become more difficult to treat the disease due the emergence and spread of resistance to recommended antimalarial drugs including ACTs, necessitating an urgent search for antimalarial compounds with unique modes of action. Here, we investigated the antimalarial activity, antioxidant and antiinflammatory capacity of Enantia chlorantha aqueous stem bark extract (EcASBE) in vivo. Methods: The extract was screened for selected phytoconstituents including alkaloids and flavonoids. We evaluated the antimalarial activity of EcASBE against Plasmodium berghei NK65 infection in mice, using curative, prophylactic, and suppressive antimalarial test models, respectively. In addition, the antioxidant and antiinflammatory activities of the extract were assessed. Results: The EcASBE significantly (p < 0.05) inhibited parasitaemia dose-dependently, with the highest inhibition (80.4%) and prolonged survival (MST=20) observed in the curative test. Our findings reveal significant (p < 0.05) improvement of serum ALT, AST, ALP, GGT, and levels of TNF-α, creatinine and urea following extract administration. Furthermore, the extract led to a significant (p < 0.05) rise in the levels of CAT, SOD, GPx, and GSH, with a concomitant reduction in NO and MDA levels. Conclusion: The antimalarial, antioxidative, antiperoxidative, and inflammatory-inhibiting properties of the plant in infected mice demonstrate its great value for therapeutic intervention, and substantiate its use in traditional medicine for malaria treatment. Hence, further investigation to identify the repertoire of the active antimalarial components is warranted.

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confidence: 99%

Aqueous extract of Enantia chlorantha Oliv. demonstrates antimalarial activity and improves redox imbalance and biochemical alterations in mice

Evbuomwan,

Adeyemi,

Oluba

2024

Preprint

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Micromorphological and Phytochemical Evaluation of Heliotropium rariflorum Stocks From Karak, Pakistan

Ul Uza,

Dastagir

2024

Microscopy and Microanalysis

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Micromorphological and phytochemical studies play a major role in quality control and standardization of traditional or herbal medications. In the present research, micromorphological assessment of Heliotropium rarifloum stocks was performed through light and scanning electron microscopies (LM & SEM). The anatomy of leaves, stem and root showed salient histological features. Both surfaces of the leaves had setose glandular trichomes measuring 20–38 × 6–15 µm. The lower epidermis had comparatively a maximum anomocytic stomata (16–35) and stomatal index (12–33). The mature pollen grains were small (74 µm) and spheroidal shaped, with psilate exine (2 μm) sculpturing. Vein termination and vein islet number of the upper epidermis were 5–20 and 5–15, respectively. The palisade ratio of the leaf lamina for the upper and lower epidermis was 2–10 and 2–8. LM and SEM of the powdered samples displayed crystals, phloem fibers, xylem, vessels, sieve tube elements, companion cells, and tracheids. Extractive values determination, fluorescence, and phytochemical analysis were employed for quality control according to the World Health Organization (WHO) guidelines. Phytochemical screening revealed various secondary metabolites. It is suggested that H. rariflorum might be a reliable source of nutrients and secondary metabolites and might be more medically effective. The current findings confirm its standardization and validation.

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Ganoderic Acid Tq in Daixie Jiangzhi Formula Improves Type 2 Diabetes Combined with Nonalcoholic Fatty Liver Disease Through Pparg/Fabp4 Pathway

Zhang,

Yang

2024

Preprint

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Phytochemical screening, antioxidant analyses, and in vitro and in vivo antimalarial activities of herbal medicinal plant - Rotheca serrata (L.) Steane & Mabb.

Cited by 4 publications

References 62 publications

Aqueous extract of Enantia chlorantha Oliv. demonstrates antimalarial activity and improves redox imbalance and biochemical alterations in mice

Aqueous extract of Enantia chlorantha Oliv. demonstrates antimalarial activity and improves redox imbalance and biochemical alterations in mice

Micromorphological and Phytochemical Evaluation of Heliotropium rariflorum Stocks From Karak, Pakistan

Ganoderic Acid Tq in Daixie Jiangzhi Formula Improves Type 2 Diabetes Combined with Nonalcoholic Fatty Liver Disease Through Pparg/Fabp4 Pathway

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