Phytochemical screening, antibacterial and anthelmintic activities of leaf and seed extracts of Coix lacryma-jobi L.

Das, Sajan; Akhter, Rumana; Khandaker, Sumana; Huque, Sumaiya; Das, Promit; Anwar, Md. Rafi; Tanni, Kaniz Afroz; Shabnaz, Samia; Shahriar, Mohammad

doi:10.12980/jclm.5.2017j7-65

Cited by 15 publications

(13 citation statements)

References 29 publications

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“…Drude, Rumex nepalensis (Spreng), C. lacryma-jobi, and O. wightiana contain the major pharmaceutical constituents such as glycosides, flavonoids, terpenoids, and saponins. The obtained resulted is well supported by the literature [16,17]. These are the bioactive components which are known to be as bactericidal, pesticidal in nature [18][19][20].…”

Section: Subba and Timilsinasupporting

confidence: 84%

“…It also revealed that the plant extract has great potential as antimicrobial compounds, especially in the treatment of infectious diseases caused by resistant microorganisms. In contrast, the references are also available regarding the antimicrobial activity of E. debile [26], L. ovalifolia and O. wightiana [27], J. adhatoda, [28], R. ellipticus [29], and C. lacremajobi [16], but for all these plant extracts antibacterial activity has not been observed.…”

Section: Antibacterial Activitymentioning

confidence: 99%

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Scientific Validation of Some Nepalese Medicinal Plants From Nangle Bhare of Kathmandu, Nepal

Subba

Timilsina

2019

Asian J Pharm Clin Res

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Objective: The present study was designed to provide scientific support for the medicinal properties of traditionally used medicinal plants of Nangle Bhare, Kathmandu, Nepal. Methods: Plant extracts were prepared by cold percolation method using methanol solvent. Analysis of phytochemical constituents was carried out using standard methods. The brine shrimp toxicity assay for each extract was carried out according to Mayer et al. The 1, 1-diphenyl-2-picrylhyrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assay were used to evaluate in vitro antioxidants activities. The antimicrobial activity of the plant extracts was carried by the disc diffusion method. Results: Phytochemical analysis revealed the availability of secondary metabolites such as reducing compounds, glycosides, and flavonoids in the methanolic extract of eight plants, namely, frond of Cheilanthes farinosa, leaves of Lyonia ovalifolia, leaves and roots of Rumex nepalensis, aerial stem of Equisetum debile, roots of Coix lacrema-jobi, leaves of Justica adhatoda, leaves of Osyris wightiana, and roots of Rubus ellipticus collected from Nangle Bhare village of Kathmandu district. The brine shrimp bioassay revealed that roots and leaves of R. nepalensis only exhibited lethality against brine shrimp. Frond of C. farinosa and roots of R. nepalensis exhibited good antimicrobial activity against Staphylococcus aureus and Escherichia coli. Both DPPH and FRAP assays showed that among the plant under study, R. ellipticus has lower inhibitory concentration IC50 values than other plants such as L. ovalifolia, R. nepalensis, and C. farinose. Conclusions: On the basis of this study, it was found that scientifically only four, namely C. farinosa, L. ovalifolia, R. nepalensis, and R. ellipticus have medicinal potentials.

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Section: Subba and Timilsinasupporting

confidence: 84%

Section: Antibacterial Activitymentioning

confidence: 99%

Scientific Validation of Some Nepalese Medicinal Plants From Nangle Bhare of Kathmandu, Nepal

Subba

Timilsina

2019

Asian J Pharm Clin Res

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“… 2005 ; Das et al . 2017 ) have been reported to have antimicrobial properties. However, we also observed plants with similar medicinal uses to have a low culturable diversity of ME isolates, namely Calophyllum inophyllum and Memecylon malabaricum (Table S1, Supporting Information).…”

Section: Discussionmentioning

confidence: 99%

Culturable diversity of bacterial endophytes associated with medicinal plants of the Western Ghats, India

Webster

Mullins

Cunningham-Oakes

et al. 2020

FEMS Microbiology Ecology

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Bacterial endophytes are found in the internal tissues of plants and have intimate associations with their host. However, little is known about the diversity of medicinal plant endophytes (ME) or their capability to produce specialised metabolites that may contribute to therapeutic properties. We isolated 75 bacterial ME from 24 plant species of the Western Ghats, India. Molecular identification by 16S rRNA gene sequencing grouped MEs into 13 bacterial genera, with members of Gammaproteobacteria and Firmicutes being the most abundant. To improve taxonomic identification, 26 selected ME were genome sequenced and average nucleotide identity (ANI) used to identify them to the species-level. This identified multiple species in the most common genus as Bacillus. Similarly, identity of the Enterobacterales was also distinguished within Enterobacter and Serratia by ANI and core-gene analysis. AntiSMASH identified non-ribosomal peptide synthase, lantipeptide and bacteriocin biosynthetic gene clusters (BGC) as the most common BGCs found in the ME genomes. Five of the ME isolates belonging to Bacillus, Serratia and Enterobacter showed antimicrobial activity against the plant pathogen Pectobacterium carotovorum. Using molecular and genomic approaches we have characterised a unique collection of endophytic bacteria from medicinal plants. Their genomes encode multiple specialised metabolite gene clusters and the collection can now be screened for novel bioactive and medicinal metabolites.

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“…The non-toxic form of nanoparticles have been used in cancer therapy [39,40]. Considering the biological activities of Coix lacryma jobi, which acts as antioxidant [41], cytotoxic activities [42] and its leaves extracts at a different medium that inhibits various cancer cells such as Hela, HepG2, and SGC-7901 [43,44], hepatoprotective and anti-inflammatory activity [45] antitumor activities in human cervical cells [46] antibacterial and anthelmintic activities [47] were observed. However, the preparation of green CuO NPs using Coix lacryma jobi leaves has not yet been reported to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 99%

Green Synthesis of Copper Oxide Nanoparticles Using Coix lacryma jobi Leaves Extract and Screening of its Potential Anticancer Activities

Devi

Singh

Velmurugan

et al. 2021

JPRI

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Background: Copper oxide nanoparticles(CuO NPs) have been powerful evidence in several in vitro studies such as cytotoxicity and antimicrobial compared with other metal oxide. Here, we have synthesized green CuO NPs using Coix lacryma jobi leaves extracts. Place and Duration of Study: Department of Chemistry Manipur University, Manipur, India and Regional Institute of Medical Sciences, Imphal, India between February 2019 to March 2021. Methodology: Green CuO NPs nanoparticles were synthesized from Copper chloride dihydrate (CuCl2.2H2O) using Coix lacryma jobi leaves extract, and the synthesized green CuO NPs were characterized using Field Emission Scanning Electron Microscopy (FESEM) - Energy Dispersive Spectroscopy, IR Spectroscopy, UV-Visible Spectroscopy, Powder X-Ray diffraction Spectroscopy and HR-TEM where FESEM-EDS determined the purity of CuO NPs. Results: No other impurities present were observed in EDS, and the PXRD spectra show the crystallite size of CuO NPs with respect to the (002) plane is found to be 25.2 nm, and the presence of CuO NPs at adsorption spectrum with a distinct peak at 282 nm was determined by UV-Visible spectroscopy and the homogenous morphology and crystalline nature of the CuO NPs were determined from TEM micrograph and SAED pattern. In applications, the substantial anticancer activity of green CuO NPs (synthesized using Coix lacryma jobi leaves extract) was proved on human cervical and lung cancer cell lines with IC50 values of 31.88 μg/ml and 15.61 μg/ml, respectively.

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Phytochemical screening, antibacterial and anthelmintic activities of leaf and seed extracts of Coix lacryma-jobi L.

Cited by 15 publications

References 29 publications

Scientific Validation of Some Nepalese Medicinal Plants From Nangle Bhare of Kathmandu, Nepal

Scientific Validation of Some Nepalese Medicinal Plants From Nangle Bhare of Kathmandu, Nepal

Culturable diversity of bacterial endophytes associated with medicinal plants of the Western Ghats, India

Green Synthesis of Copper Oxide Nanoparticles Using Coix lacryma jobi Leaves Extract and Screening of its Potential Anticancer Activities

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