Phytochemical Screening, Antibacterial Activity and Bioautography of &amp;lt;i&amp;gt;Sorindeia madagascariensis&amp;lt;/i&amp;gt;, &amp;lt;i&amp;gt;Mucuna stans&amp;lt;/i&amp;gt;, and &amp;lt;i&amp;gt;Albizia harveyi&amp;lt;/i&amp;gt;

Makoye, Paul Malaba; Daniel, Innocent John; Mbunde, Mourice Nyangabo; Masota, Nelson E.; Sempombe, Joseph; Mugoyela, Veronica

doi:10.11648/j.jdmp.20200603.12

Cited by 2 publications

(3 citation statements)

References 24 publications

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“…e results of the present study agreed well with previous reports on A. coriaria stem bark which reported the presence of tannins, saponins, alkaloids, flavonoids, terpenes, and cardiac glycosides as the major secondary metabolites [50][51][52][53][54][55]62]. Further, the identified metabolites have been previously reported in the leaf extracts of other Albizia species such as A. lebbeck (L.) Benth [93] and A. harveyi [76]. e absence of alkaloids was previously reported for ethyl acetate and aqueous extracts of A. lebbeck leaves [93,94] and A. zygia leaves [95] as well as ethanolic leaf extracts of A. harveyi [76].…”

Section: Phytochemical Screening Of a Coriaria Leavessupporting

confidence: 92%

“…Further, the identified metabolites have been previously reported in the leaf extracts of other Albizia species such as A. lebbeck (L.) Benth [93] and A. harveyi [76]. e absence of alkaloids was previously reported for ethyl acetate and aqueous extracts of A. lebbeck leaves [93,94] and A. zygia leaves [95] as well as ethanolic leaf extracts of A. harveyi [76]. e total absence of steroids in A. coriaria leaves corroborates a previous observation in which steroids were absent in ethyl acetate and aqueous extracts of A. lebbeck leaves [94].…”

Section: Phytochemical Screening Of a Coriaria Leavesmentioning

confidence: 57%

“…Antibacterial activity of A. coriaria leaf extracts was tested against American Type Culture Collection bacterial strains of E. coli, S. aureus, P. aeruginosa, and S. typhi in the Biological Sciences Laboratory, Moi University, Kenya. Selection of the bacteria was based on the diseases for which the leaves are traditionally used, the WHO priority list, and availability [75,76]. All materials, including bacterial media used in the assay, were autoclaved at 121°C and 15 psi pressure for 30 minutes in an All-American ® Steam Sterilizer (Model No.…”

Section: Antibacterial Screening Of a Coriaria Leaf Extractsmentioning

confidence: 99%

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Intraspecific Variation of Phytochemicals, Antioxidant, and Antibacterial Activities of Different Solvent Extracts of Albizia coriaria Leaves from Some Agroecological Zones of Uganda

Omara

Kiprop

Kosgei

2021

Evidence-Based Complementary and Alternative Medicine

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Albizia coriaria Welw ex. Oliver is a customary African medicinal plant, which has a long history of utilization in the management of oxidative stress-induced and bacterial diseases. However, there is no report on the phytochemicals, antioxidant, and antibacterial activities of its leaves. The aim of this study was therefore to compare the phytochemicals, antioxidant, and antibacterial potential of A. coriaria leaves from Jinja, Kole, and Mbarara districts of Uganda. Shade-dried leaf samples were ground into powder and successively extracted with ethyl acetate, ethanol, and distilled water. Phytochemical screening indicated the presence of alkaloids, phenols, saponins, flavonoids, cardiac glycosides, tannins, and terpenes as the major secondary metabolites in the extracts. Total phenolic and flavonoid contents and total in vitro antioxidant activity were found to be the highest for ethanolic extracts, with the highest contents (101.72 ± 0.22 mg GAE/g DW; 13.23 ± 0.03 mg QE/g DW) and antioxidant potential (IC50 = 18.65 ± 0.06 mg/mL) being for leaves from Mbarara district. Antibacterial activity of the extracts determined by agar disc diffusion method revealed that ethanolic extracts had higher antibacterial activities with mean zones of inhibition of 6.00 ± 1.73 to 10.00 ± 1.73 mm, 5.00 ± 1.00 to 12.30 ± 1.53 mm, 17.00 ± 0.00 to 25.00 ± 2.65 mm, and 9.00 ± 1.73 to 16.00 ± 1.73 mm for Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella typhi, respectively. Ethyl acetate extracts of A. coriaria leaves from Kole and Mbarara had lower antibacterial activities, while aqueous extracts and ethyl acetate extract of leaves from Jinja showed no antibacterial activity. The current study for the first time established that A. coriaria leaves possess therapeutic phytochemicals with significant in vitro antioxidant and antibacterial activities, which lend credence to their use in traditional management of oxidative stress-induced conditions and bacterial diseases in Uganda. Structural elucidation of the responsible pure compounds for the observed bioactivities as well as toxicity studies of the extracts is recommended.

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