Phytochemical screening and toxicity profiles of crude extracts of Cissus quadrangularis L. and Solunum incanum L. in mice

Feyera, Teka; Assefa, Solomon; Mekonnen, Endalkachew; A, Legesse

doi:10.5897/ajpp2017.4811

Cited by 4 publications

(4 citation statements)

References 24 publications

(21 reference statements)

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“…Acute toxicity in rodents was performed earlier at the maximum dose, that is, 2000 mg/kg. [16] Extracts caused no visible signs of acute toxicity at the maximum dose, hence, were not performed. [16] Studies have shown that exposure to rotenone altered behavioral and motor deficits, which are similar to human PD, counting muscular rigidity (catalepsy), postural instability, bradykinesia, and unsteady gait.…”

Section: Discussionmentioning

confidence: 99%

“…[16] Extracts caused no visible signs of acute toxicity at the maximum dose, hence, were not performed. [16] Studies have shown that exposure to rotenone altered behavioral and motor deficits, which are similar to human PD, counting muscular rigidity (catalepsy), postural instability, bradykinesia, and unsteady gait. [23] A decrease in movement, catalepsy was observed when zebrafish was exposed to rotenone at a dose of 3 pg/mL.…”

Section: Discussionmentioning

confidence: 99%

“…Hence, it can be concluded that an increase in catalase and GSH may help in improving cognition symptoms. [24] Phytochemical studies of C. quadrangularis have revealed the presence of flavonoids such as quercetins and kaempferols, daidzein, triterpenoids, and Vitamin C. [16] The presence of phenolic compounds and triterpenoids may explain the anticonvulsant and NMDA antagonistic activity of the plant as they are possessing actions against Parkinson disease. [13]…”

Section: Discussionmentioning

confidence: 99%

“…Hence acute toxicity was not performed in mice and doses of 200mg/kg and 500 mg/kg has been selected for the study. [16] For zebrafish…”

Section: For Micementioning

confidence: 99%

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2023

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Background: Parkinson's disease (PD) caused due to neuroinflammation and oxidative stress associated with motor and non-motor complications. Neuroprotection strategies create a hope for patients. Natural products have been increasing the gain to have specific molecular or pharmacological activities that are likely to supply the development of neuroprotective agents against PD. Cissus quadrangularis constitutes all suitable physical and chemical properties and its ability to cross the blood-brain barrier making it a relevant candidate for the treatment of neuroprotection in PD. Materials and Methods: The stem part of the plant was extracted with distilled water and ethanol. The antiparkinson's activity of both extracts of C. quadrangularis was evaluated using rotenoneinduced excitotoxicity model in zebrafish for 96 h resulting in alterations in swimming pattern measured through a video recording system. Further, cognitive improvement activity in PD of both extracts of plant was evaluated using reserpine-induced cognitive impairments in mice for 29 days. Biochemical parameters, that is, levels of catalase and glutathione (GSH) were analyzed using UV-visible spectrophotometer. Results: The aqueous extract of C. quadrangularis (AECQ) showed a significant and dose-dependent effect against rotenone-induced PD in adult zebrafish's at a dose of 4 and 10 µg/mL and cognitive improvement activity against reserpine-induced cognitive impairment in mice at a dose of 200 mg/kg and 500 mg/kg. The AECQ also showed a significant in vivo antioxidant potential by restoring the levels of catalase and GSH. The results of the present study demonstrate the potential antiparkinson's properties of the aqueous extract. Conclusion: The result of the present study conclusively shows the Anti-Parkinson's activity of C. quadrangularis and improved cognition in PD.

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Section: Discussionmentioning

confidence: 99%