Phytochemical Screening and Test of Antioxidant Activity in the Extract of Mangosteen Rind

Sinaga, Rika Nailuvar; Siregar, Nurhamida Sari

doi:10.26911/theicph.2016.057

Cited by 4 publications

(4 citation statements)

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“…Following the methanol extraction method, it was found that MPE includes six secondary metabolites (see Table 2 ). It has been reported that MPE does contain many alkaloids, polyphenols, flavonoids, tannins, saponins, and quinones [ 32 ]. Therefore, MPE is known to have high antioxidant properties [ 3 , 33 ].…”

Section: Resultsmentioning

confidence: 99%

Preparation of Mangosteen Peel Extract Microcapsules by Fluidized Bed Spray-Drying for Tableting: Improving the Solubility and Antioxidant Stability

et al. 2022

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Mangosteen fruit has been widely consumed and used as a source of antioxidants, either in the form of fresh fruit or processed products. However, mangosteen peel only becomes industrial waste due to its bitter taste, low content solubility, and poor stability. Therefore, this study aimed to design mangosteen peel extract microcapsules (MPEMs) and tablets to overcome the challenges. The fluidized bed spray-drying method was used to develop MPEM, with hydroxypropyl methylcellulose (HPMC) as the core mixture and polyvinyl alcohol (PVA) as the coating agent. The obtained MPEM was spherical with a hollow surface and had a size of 411.2 µm. The flow rate and compressibility of MPEM increased significantly after granulation. A formula containing 5% w/w polyvinyl pyrrolidone K30 (PVP K30) as a binder had the best tablet characteristics, with a hardness of 87.8 ± 1.398 N, friability of 0.94%, and disintegration time of 25.75 ± 0.676 min. Microencapsulation of mangosteen peel extract maintains the stability of its compound (total phenolic and α-mangosteen) and its antioxidant activity (IC50) during the manufacturing process and a month of storage at IVB zone conditions. According to the findings, the microencapsulation is an effective technique for improving the solubility and antioxidant stability of mangosteen peel extract during manufacture and storage.

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Section: Resultsmentioning

confidence: 99%

Preparation of Mangosteen Peel Extract Microcapsules by Fluidized Bed Spray-Drying for Tableting: Improving the Solubility and Antioxidant Stability

et al. 2022

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“…Saponins inhibit growth and embryonic development. Saponins can be absorbed, resulting in osmotic power, and the embryo becomes unbalanced, causing embryonic fluid to be absorbed out of the membrane and the embryo cells to shrink as a result of plasmolysis, and ultimately, the embryo will die 13,14 .…”

Section: Hatching Ratementioning

confidence: 99%

effect of Garcinia mangostana L. skin decoct exposure on Zebrafish embryo Danio rerio (Hamilton, 1822)

Yunita,

Retnoaji

2023

Biological. environ. pollut.

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Hypertension is one of the diseases with the highest prevalence in Indonesia and is the main cause of death in patients. Pregnant women have a risk of losing their baby due to hypertension or death. ACEI and ARB-type antihypertensive drugs are dangerous for pregnant women because they can cause fetal death. In ancient times, Indonesians have used plants as herbal medicines for generations. One of the plants that has medicinal properties is mangosteen skin (Garcinia mangostana L.) as an antihypertensive drug through its diuretic effects. However, the drugs consumed can have toxic effects if used in high concentrations. A teratogenic test is a toxic test that is specifically carried out to determine the presence of organ abnormalities in the fetus due to exposure to xenobiotic compounds. The zebrafish (Danio rerio) embryo was chosen as the research object because the chorion in the embryonic phase is transparent, so it is easy to observe. This study aimed to determine the effect of exposure to mangosteen rind decoction on zebrafish embryos' hatchability and spinal curvature. Observations were made using a Leica microscope with ANOVA data analysis. The observations showed that high treatment concentrations decreased heart rate, while high concentrations didn’t affect egg hatching rate, spine curvature, or pigment density.

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“…According to the ethanol extraction method, MPE contains six secondary metabolites (see Table 2). MPE has been found to possess a high concentration of polyphenols, flavonoids, tannins, saponins, and quinones (14). As a result, MPE is recognized to have solid antioxidant capabilities (15,16).…”

Section: Extract Propertiesmentioning

confidence: 99%

Instant Granules of Mangosteen Peel (Garcinia Mangostana L.) Ethanol Extract as Antioxidants

Fadhila

Sriwidodo

Chaerunisaa

2022

sciphar

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Free radicals in the air can trigger dangerous diseases, such as cancer and premature aging. To avoid this, antioxidant compounds are needed to donate electrons to free radicals, causing them to become more stable. A powerful antioxidant can be found in nature, including the mangosteen peel. This study aimed to find the best instant granule preparation formula from mangosteen peel extract (MPE) that can be practically consumed and the antioxidant stability during preparation. The wet granulation method was used to make instant granules, which have four formulas with varying amounts of xanthan gum as a suspending agent and maltodextrin as a solubility enhancer. The antioxidant activity was examined using the DPPH method. Based on the findings, formula 4 had the best properties with a drying shrinkage of 1.80%, a flow rate of 11.54 ± 1.56 g/s, repose's angle of 29.112 ± 0.45ᵒ, carr index of 14.043 ± 1.9%, and dispersion rate of 0.164 g/s. There is no residue in the solution. The shape and taste of this formula were most acceptable. The antioxidant activity of the extract and instant granules was not significantly different, with the IC50 of 34.64 μg/ml and 44.12 μg/ml, respectively. Based on the test result, it can be concluded that formula 4 with a concentration of xanthan gum 1% and 20% maltodextrin is a potent antioxidant supplement.

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Phytochemical Screening and Test of Antioxidant Activity in the Extract of Mangosteen Rind

Cited by 4 publications

References 0 publications

Preparation of Mangosteen Peel Extract Microcapsules by Fluidized Bed Spray-Drying for Tableting: Improving the Solubility and Antioxidant Stability

Preparation of Mangosteen Peel Extract Microcapsules by Fluidized Bed Spray-Drying for Tableting: Improving the Solubility and Antioxidant Stability

effect of Garcinia mangostana L. skin decoct exposure on Zebrafish embryo Danio rerio (Hamilton, 1822)

Instant Granules of Mangosteen Peel (Garcinia Mangostana L.) Ethanol Extract as Antioxidants

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