Phytochemical Screening and Potential Antibacterial Activity of Defatted and Nondefatted Methanolic Extracts of Xao Tam Phan (Paramignya trimera (Oliv.) Guillaum) Peels against Multidrug-Resistant Bacteria

Thi, Van-Anh Le; Nguyen, Ngoc-Lien; Nguyen, Quoc Tuan; Dong, Quyen Van; Do, Thi-Yen; T., Kieu-Oanh Nguyen

doi:10.1155/2021/4233615

Cited by 7 publications

(8 citation statements)

References 21 publications

(39 reference statements)

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“…4 EOs have been reported to have various pharmacological effects such as powerful antibacterial, antifungal, anti-trichomonas, antioxidant, antiviral, anti-inflammatory, cytotoxic, and anticancer activities. 4–6,12,13 Recently, some scientists have reported that EOs from different plant parts inhibit enzymes related to diabetes and melasma skin such as α -amylase (eg, Eruca vesicaria subsp. longirostris , Mentha longifolia var.…”

Section: Resultsmentioning

confidence: 99%

Essential Oils From the Trunks and Leaves of Paramignya scandens (Griff.) Craib From Vietnam: Phytochemical Composition, In Vitro α-Amylase and Tyrosinase Inhibitory Activities and In Silico Molecular Docking Studies

Tran-Trung,

Thang,

Nguyen

et al. 2023

Natural Product Communications

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Objective/Background: This work aims to evaluate the chemical composition of Paramignya scandens essential oils (EOs), their in vitro α-amylase, tyrosinase inhibitory activities, and in silico molecular docking study. Methods: The EOs of P scandens trunks and leaves were extracted by hydrodistillation process and the chemical compositions were determined by gas chromatography-mass spectrometry. These EOs were also tested for in vitro α-amylase and tyrosinase inhibitory activities. Additionally, in silico molecular docking simulations on the main components of the EOs were performed. Results: The EO profiles of P scandens trunks and leaves included 21 (98.8%) and 34 (89.7%) components, respectively. The main compounds in the trunk EO were ( E)- β-caryophyllene (60.8%), α-humulene (13.0%), and germacrene D (7.4%). The predominant compounds of the leaf EO were caryophyllene oxide (16.7%), ( E) -β-caryophyllene (14.6%), spathulenol (12.2%), germacrene D (6.5%), and α-humulene (5.0%). Moreover, their α-amylase and tyrosinase inhibitory effects were demonstrated for the first time. In molecular docking results, ( E)- β-caryophyllene was the potential compound in EOs with the best binding affinity against the α-amylase enzyme, whereas spathulenol revealed the strongest binding ability with the tyrosinase enzyme. Furthermore, the assessment of potential interactions between the main components of the EOs and the selected proteins was elucidated. Conclusions: The results of this work revealed that EOs of P scandens trunks and leaves had α-amylase and tyrosinase inhibition properties and potential applications in nutraceuticals, medicine, and cosmetics.

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Section: Resultsmentioning

confidence: 99%

Essential Oils From the Trunks and Leaves of Paramignya scandens (Griff.) Craib From Vietnam: Phytochemical Composition, In Vitro α-Amylase and Tyrosinase Inhibitory Activities and In Silico Molecular Docking Studies

Tran-Trung,

Thang,

Nguyen

et al. 2023

Natural Product Communications

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“…The alkaloids identification was by adding the Dragendroff, Bouchardat and Meyer reagents to the test tube. The formation of orange to reddish, brown and white to yellowish was the sign of alkaloids presence, respectively ( 12 , 13 ). The flavonoids identification was by adding 0.1 mg of magnesium powder, 1 ml of amyl alcohol and hydrogen chloride to the test tube.…”

Section: Methodsmentioning

confidence: 99%

“…The glycosides identification was by mixing 5 ml of extract and 25 ml of H 2 SO 4 , then heated to boiling points for 15 minutes then cooled and added NaOH, next with 5 ml Fehling solution. The formation of red brick indicated the presence of glycosides ( 12 ). Saponins identification by heating the extract to its boiling point then shake until the formation of foam layer that indicated the presence of saponins ( 13 ).…”

Section: Methodsmentioning

confidence: 99%

Phytochemical Analysis by FTIR of Zanthoxylum Acanthopodium, DC Fruit Ethanol Extract, N-hexan, Ethyl Acetate and Water Fraction

Megawati¹,

Bangun²,

Putra³

et al. 2023

Med Arch

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Background:Andaliman fruit is used as spice in Batak cuisine, North Sumatera, Indonesia. The potency of andaliman fruit extract as herbal medicine is widely studied. Many studies elaborate the benefits of andaliman fruit extract as an antioxidant, antibacterial or anticancer. Objective: The aim of this study was to identify the phytochemical compounds of andaliman fruit extract and its fractions. Methods: The andaliman fruit was originated from Balige city, Tobasa Regency, North Sumatera. The extract was made by maceration within ethanol and followed by fractionation with n-hexan, ethyl acetate and water. The phytochemical screening by chemical reactions, thin layer chromatography, and Fourier Transform Infrared Spectrophotometer were performed. Results: This study found andaliman fruit ethanol extract consists of alkaloids, flavonoids, glycosides, tannins, triterpens, and steroids. The n-hexan fraction consists of triterpens and steroids, ethyl acetate fraction consists of flavonoids and glycosides, and water fraction consists of alkaloid, flavonoid, and glycosides. Andaliman fruit ethanol extract had eight color spots, n-hexan and ethyl acetate fraction had five color spots and water fraction had two color spots. Andaliman fruit ethanol extract had functional group of C-H alkanes, =C-H alkenes (aliphatic), O-H, C=C alkenes, C=C aromatics, C≡C alkynes, C-O, C=O, and NO2. The n-hexan fraction had C-H alkanes, =C-H alkenes (aliphatic), O-H, C=C alkenes, C-O, C=O, and NO2. The ethyl acetate fraction had C-H alkanes, =C-H alkenes (aliphatic), O-H, C=C alkenes, C=C aromatics, C-O, C=O, and NO2. The water fraction had C-H alkanes, =C-H alkenes (aliphatic), O-H, C=C aromatics, C≡C alkynes, and C-O. Conclusion: Phytochemical screening found that andaliman fruit ethanol extract, n-hexan, ethyl acetate and water fraction positive of phytochemical compounds. The FTIR of andaliman fruit ethanol extract, n-hexan fraction, ethyl acetate fraction, and water fraction showed the absorbance of C-H alkanes, O-H, C-O, and C=C alkenes indicating the presence of alkaloids, flavonoids, and triterpenoid saponin.

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“…The alkaloids in the extract formed a reddish (Dragendorff reagent), brown (Bouchardat reagent) and white to yellowish (Meyer reagent) color in the test tube. 11,12 To identify the glycosides, we started by addition of 25 ml of H 2 SO 4 to 5 ml of extract then boiled for 15 minutes. After the mixture cooled off , NaOH and 5 ml Fehling solution added and red brick color formation indicated the presence of glycosides.…”

Section: Phytochemical Screeningmentioning

confidence: 99%

Phytochemical Screening, Thin Layer Chromatography and Fourier Transform Infra-Red Spectroscopy Analysis of Eleutherine Bulbous (Mill.) Urb Bulb Extract

Lubis,

Siregar,

Farhat F

et al. 2024

Pharmacogn J.

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Background: Many traditional medicinal plants were studied for their phytochemical components. Dayak onions (Eleutherine bulbous (Mill.) Urb) is one of traditional medicinal plant in Indonesia. Analysis of the phytochemical compounds in the extract of the plant would help in determining various biological activities of the plant. Objective: This study was primarily aimed to identify the phytochemical profile of Dayak onions extract and its fractions. Methods: The Dayak onion bulbs were collected from Pancur Batu District, North Sumatra Province, Indonesia. Multiple solvents used to for extraction and analysis of phytochemical compound by chemical reactions, thin layer chromatography (TLC) profiling, and Fourier Transform Infrared Spectrophotometer (FTIR) profiling. Results: The phytochemical screening of Dayak onions ethanol extract showed it contained alkaloids, flavonoids, glycosides, tannins, and triterpenes/ steroids. The n-hexane fraction contained flavonoids and triterpenes/steroids, while the ethyl acetate fraction contains flavonoids and glycosides. The water fraction contained alkaloids, flavonoids, glycosides and tannins. By TLC profiling, the bioactive compounds in ethanol extract of the Dayak onion contain steroids, tannins, flavonoids and alkaloids. The bioactive compound in ethyl acetate fraction contains steroids, tannins, triterpenes, flavonoids and glycosides. The bioactive compound in n-hexan fraction contains steroids. The bioactive compound in water fraction fraction contains steroids and tannins. The FTIR demonstrated the presence of C-H alkanes, =C-H alkenes (aliphatic), C-O alcohol, ether, esters and carboxy acid in the ethanol extract, en-hexan fractions and ethyl acetate fractions. Conclusion: The phytochemical qualitative profiling showed that Dayak onion bulb as a rich source of bioactive compounds and have medicinal potential as therapeutic agent. A higher content of bioactive compounds of Dayak onion bulbs found in the ethanol and ethyl acetate extracts. The FTIR demonstrated the presence of C-H alkanes, =C-H alkenes (aliphatic), C-O alcohol, ether, esters and carboxy acid in the ethanol extract, enhexan fractions and ethyl acetate fractions.

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Phytochemical Screening and Potential Antibacterial Activity of Defatted and Nondefatted Methanolic Extracts of Xao Tam Phan (Paramignya trimera (Oliv.) Guillaum) Peels against Multidrug-Resistant Bacteria

Cited by 7 publications

References 21 publications

Essential Oils From the Trunks and Leaves of Paramignya scandens (Griff.) Craib From Vietnam: Phytochemical Composition, In Vitro α-Amylase and Tyrosinase Inhibitory Activities and In Silico Molecular Docking Studies

Essential Oils From the Trunks and Leaves of Paramignya scandens (Griff.) Craib From Vietnam: Phytochemical Composition, In Vitro α-Amylase and Tyrosinase Inhibitory Activities and In Silico Molecular Docking Studies

Phytochemical Analysis by FTIR of Zanthoxylum Acanthopodium, DC Fruit Ethanol Extract, N-hexan, Ethyl Acetate and Water Fraction

Phytochemical Screening, Thin Layer Chromatography and Fourier Transform Infra-Red Spectroscopy Analysis of Eleutherine Bulbous (Mill.) Urb Bulb Extract

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